NIR Imaging Applications in the Pharmaceutical Industry

Gerich, Ad; Dubois, Janie; Kidder, Linda H.

doi:10.1002/9780470768150.ch11

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Applications of chemical imaging can be found in a wide variety of industries and sciences, including methods to quantify the concentration and assess the distribution of chemical components within matrices of pharmaceutical (Amigo and Ravn 2009;Cairos et al 2009;Gendrin, Roggo, and Collet 2008;Gerich, Dubois, and Kidder 2010;Lopes and Wolff 2009;Maurer and Leuenberger 2009), biomedical (Kalasinsky and Lewis 2004;Lee et al 2010;Li et al 2009), and polymer science (De Biasio et al 2010;Furukawa et al 2007;Gosselin, Rodrigue, and Duchesne 2008;Gosselin et al 2009) origin. For such an analysis, a spectrum is collected at each pixel location of the image and the chemical composition is determined for each pixel from an analysis of the resulting spectrum.…”

Section: Introductionmentioning

confidence: 99%

Chemical Imaging with a Solid-State near Infrared Spectrometer Based on a Digital Micro-Mirror Array Device Coupled with Hadamard Transform Spectroscopy

Xiang

Arnold

2012

Analytical Letters

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Chemical imaging is demonstrated by using an innovative near infrared spectrometer that uses a digital micro-mirror array device (DMD) to provide both spatial and spectral resolution. Hadamard transform spectroscopy is used to enhance the signal-to-noise ratio of the measurement compared to single point raster scanning. The concept is demonstrated by collecting a spectral image of a polymer sample composed of separate regions of polystyrene and polypropylene. The resulting image is composed of 63 spectral resolution elements across the first overtone region of the near infrared spectrum (1538-1818 nm), as well as 65 spatial resolution elements across the longitudinal direction of the DMD (11.3 mm).

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