NIR‐II Photo‐Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform against Subcutaneous Staphylococcus Aureus Infection

Abstract

Ultrasound (US)‐mediated sonodynamic therapy (SDT) has the advantages of non‐invasiveness and deep tissue penetration. Nanosystems are prominently used in sonosensitization; however, most nano‐sonosensitizers have a low reactive oxygen species (ROS) yield, thus restraining the application of SDT. Sodium molybdenum bronze nanoparticles (SMB NPs) with rich oxygen vacancies are developed and interlayer gaps of molybdenum trioxide nanobelts are expanded. Owing to the increased oxygen vacancy density and wide interlayer gap‐induced narrower band gap of SMB NPs, the electrons (e–) and holes (h+) generated by US are separated more rapidly, and oxygen vacancies prevent electrons–holes recombination under US irradiation. SMB NPs exhibit a second near‐infrared (NIR‐II) photothermal effect to promote the generation of ROS by the sonosensitizer. The SMB NPs system is successfully realized to eliminate Staphylococcus aureus (S. aureus) and dissipate biofilm. Therefore, multimodal therapy using SMB NPs serves as an effective and promising regimen for deep‐seated bacterial infections. The newly developed Mo‐based sonosensitizer is presented for the first time to demonstrate excellent antimicrobial activity through hyperthermia‐promoting SDT therapeutics. This work proposes a novel strategy in the field of NIR‐II photo‐amplified SDT with Mo‐based materials for bacterial eradication and other important biomedical applications.

Molybdenum‐Based Nanomaterials for Photothermal Cancer Therapy

“…Besides the aforementioned well-known methods, some other methods have also been reported for the preparation of Mo-NMs toward PTT application. [76,107,[189][190][191] For example, Yin et al reported a two-step method to achieve high-yield exfoliation of MoS 2 nanosheets from their bulk crystals. [189] The MoS 2 bulk crystals were first ground into thin flakes by NaCl-assisted ball-milling process and the resultant MoS 2 flakes were further treated with oleum at 90 °C for 8 h followed by sonication treatment to obtain ultrathin MoS 2 nanosheets.…”

Synthesis, biological evaluation, and molecular docking of novel hydroxyzine derivatives as potential AR antagonists

“…Finally, 10 ul CCK8 was added and incubated for 0.5–4 h, absorbance at 450 nm was determined. ( Guo et al, 2021 ; He et al, 2022a ; Hu et al, 2022 ).…”

Biosafety of inorganic nanomaterials for theranostic applications

“…Therefore, molybdenum-based nanoparticles are promising probe for various biomedical applications such as drug delivery, diagnostics, bio-imaging. Mo NPs can generate ROS under ultrasound, and it enables noninvasive treatment using Mo NPs with high penetration depth exceeding 10 cm [177,178]. Although molybdenum has relatively high biocompatibility, it is still necessary to investigate the biocompatibility characteristics according to their size, shape, and crystallinity.…”