NIR‐II Imaging‐Guided Mitochondrial‐Targeting Organic Nanoparticles for Multimodal Synergistic Tumor Therapy

Yang, Sha; Sun, Bin; Liu, Fen; Li, Na; Wang, Minghui; Wu, Peixian; Wu, Gui-Long; Fang, Huilong; He, Yuxuan; Zhou, Wei; Xiao, H.; Tan, Xiaofeng; Tang, Li; Zhu, Shoujun; Yang, Qinglai

doi:10.1002/smll.202207995

Cited by 16 publications

(5 citation statements)

References 42 publications

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“…Similar to PDT, the apoptosis of cancer cells is induced by high temperatures in PTT. Caspase-3 plays an important role during cell apoptosis and the activity of caspase-3 is considered a promising biomarker to evaluate the therapeutic effect of PTT [ 93 ]. A specific peptide substrate of caspase-3 (Asp-Glu-Val-Asp, denoted as DEVD) is usually employed for constructing apoptosis-sensitive probes [ 94 ].…”

Section: Ptt Evaluationmentioning

confidence: 99%

Visualization of Phototherapy Evolution by Optical Imaging

Zheng

Wang

2023

Molecules

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Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a non-invasive and effective approach used for cancer treatment, in which phototherapeutic agents are irradiated with an appropriate light source to produce cytotoxic reactive oxygen species (ROS) or heat to ablate cancer cells. Unfortunately, traditional phototherapy lacks a facile imaging method to monitor the therapeutic process and efficiency in real time, usually leading to severe side effects due to high levels of ROS and hyperthermia. To realize precise cancer treatment methods, it is highly desired to develop phototherapeutic agents possessing an imaging ability to evaluate the therapeutic process and efficacy in real time during cancer phototherapy. Recently, a series of self-reporting phototherapeutic agents were reported to monitor PDT and PTT processes by combining optical imaging technologies with phototherapy. Due to the real-time feedback provided by optical imaging technology, therapeutic responses or dynamic changes in the tumor microenvironment could be evaluated in a timely manner, thereby achieving personalized precision treatment and minimizing toxic side effects. In this review, we focus on the advances in the development of self-reporting phototherapeutic agents for a cancer phototherapy evaluation based on optical imaging technology to realize precision cancer treatments. Additionally, we propose the current challenges and future directions of self-reporting agents for precision medicine.

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Section: Ptt Evaluationmentioning

confidence: 99%

Visualization of Phototherapy Evolution by Optical Imaging

Zheng

Wang

2023

Molecules

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“…Therefore, many efforts have been devoted to the development of stimulus-responsive NIR-II nanomaterials to optimize FLI by responding to the tumor microenvironment (TME) or cellular signals, including redox, pH, enzymes, etc. Yang et al [32] developed a mitochondria-targeted phototherapeutic agent with the ability to target mitochondria, NIR-II FLI, and synergistic PTT/PDT/IMT tumor therapeutic effects with high performance. FE-T NPs were prepared by a simple self-assembly process from glutathione (GSH)-responsive copolymer DSPE-SS-PEG-COOH and mitochondria-targeted photosensitizer IR-FE-TPP (IR-FE modified by four TPPs) (Figure 2a).…”

Section: Polymersmentioning

confidence: 99%

Multifunctional Nanoplatform for NIR-II Imaging-Guided Synergistic Oncotherapy

Wang,

Xia,

et al. 2023

IJMS

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Tumors are a major public health issue of concern to humans, seriously threatening the safety of people’s lives and property. With the increasing demand for early and accurate diagnosis and efficient treatment of tumors, noninvasive optical imaging (including fluorescence imaging and photoacoustic imaging) and tumor synergistic therapies (phototherapy synergistic with chemotherapy, phototherapy synergistic with immunotherapy, etc.) have received increasing attention. In particular, light in the near-infrared second region (NIR-II) has triggered great research interest due to its penetration depth, minimal tissue autofluorescence, and reduced tissue absorption and scattering. Nanomaterials with many advantages, such as high brightness, great photostability, tunable photophysical properties, and excellent biosafety offer unlimited possibilities and are being investigated for NIR-II tumor imaging-guided synergistic oncotherapy. In recent years, many researchers have tried various approaches to investigate nanomaterials, including gold nanomaterials, two-dimensional materials, metal sulfide oxides, polymers, carbon nanomaterials, NIR-II dyes, and other nanomaterials for tumor diagnostic and therapeutic integrated nanoplatform construction. In this paper, the application of multifunctional nanomaterials in tumor NIR-II imaging and collaborative therapy in the past three years is briefly reviewed, and the current research status is summarized and prospected, with a view to contributing to future tumor therapy.

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“…In addition, PTT has the advantages of low invasiveness, few side effects, and high biosafety. 20–22 In recent years, researchers have developed many photothermal materials. In 2019, Wang et al synthesized rhombic dodecahedron nanocrystals (RD SnS NCs) by a one-step hydrothermal method.…”

Section: Introductionmentioning

confidence: 99%