NIR enhanced peroxidase-like activity of Au@CeO2 hybrid nanozyme by plasmon-induced hot electrons and photothermal effect for bacteria killing

Liu, Chuang; Zhang, Min; Geng, Hongqi; Zhang, Peng; Zheng, Zhi; Zhou, Yunlong

doi:10.1016/j.apcatb.2021.120317

Cited by 115 publications

(65 citation statements)

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“…Besides, the Arrhenius equation demonstrates the chemical reaction rate significantly dependent on temperature [88]. Thus, starting from these basic principles, proper external stimuli such as ATP [40,89], glucose [90], visible light irradiation [39], and NIR light irradiation [91], AMF [92] can enhance the catalytic reaction process of nanozymes through H + , H 2 O 2 , H 2 O 2 affinity, thermal, and active ion concentration modulations, thereby resulting in significantly enhanced bactericidal efficiency of nanozymes under low H 2 O 2 concentration and even neutral pH.…”

Section: External Stimuli Enhancing Catalytic Processesmentioning

confidence: 99%

“…The photothermal nanoagents can absorb the NIR and convert the optical energy into heat, which then initiates the cell membrane breakage and protein denaturation in bacteria, finally leading to their thermal ablation [102][103][104]. Based on this, NIR-responsive nanozymes, such as Au nanoplates [26], Au@Pt nanodots [32], Au NRs/CeO 2 hybrid [91], rough carbon/Fe 3 O 4 nanohybrids [102], cationic chitosan@RuO 2 hybrid [105], MoS 2 nanozymes [43,82,106], N-doped carbon nanozyme [55], PEG@Zr-Fc MOF hydrogel [107], and Fe-and Cu-N-C SAzymes [61,63,64], have been developed. Under the NIR laser irradiation, these NIR-active nanozymes can not only produce local photothermal effect, but more importantly the elevated temperature certainly accelerates catalytic reaction rate, thereby realizing the enhanced synergic CDT and PTT for effectively treating drug-resistant bacterial infections.…”

Section: Nir Stimulationmentioning

confidence: 99%

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Efficient nanozyme engineering for antibacterial therapy

et al. 2022

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Antimicrobial resistance (AMR) has posed a huge threat to human health. It is urgent to explore efficient ways to suppress the spread of AMR. Antibacterial nanozymes has become one of the powerful weapons to combat AMR due to their enzyme-like catalytic activity with a broad-spectrum antibacterial performance. However, the inherent low catalytic activity of nanozymes limits their expansion into antibacterial applications. In this regard, a variety of advanced chemical design strategies have been developed to improve the antimicrobial activity of nanozymes. In this review, we have summarized the recent progress of advanced strategies to engineering efficient nanozymes for fighting against AMR, which can be mainly classified into catalytic activity improvement, external stimuli, bacterial affinity enhancement, and multifunctional platform construction according to the basic principles of engineering efficient nanocatalysts and the mechanism of nanozyme catalysis. Moreover, the deep insights into the effects of these enhancing strategies on the nanozyme structures and properties are highlighted. Finally, current challenges and future perspectives of antibacterial nanozymes are discussed for their future clinical potential.

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Section: External Stimuli Enhancing Catalytic Processesmentioning

confidence: 99%

Section: Nir Stimulationmentioning

confidence: 99%

Efficient nanozyme engineering for antibacterial therapy

et al. 2022

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“…The HRP-like activity of PDA/Fe 3 O 4 nanozymes with different Fe contents was thus studied by using 3,3′,5,5′-tetramethylbenzidine (TMB) as peroxidase substrate. [34,36,56] The PDA/Fe 3 O 4 nanozymes could catalyze the oxidation of TMB with the existence of H 2 O 2 to produce blue oxTMB with a characteristic absorption peak at a wavelength of 652 nm (Figure 3A). The catalytic activity of PDA/Fe 3 O 4 nanozymes increased with the increase of Fe content, and reached a maximum when Fe content was 3-5% (Figure S4B, Supporting Information).…”

Section: Cascade Catalytic Property Of Pda/fe 3 O 4 Nanozymesmentioning

confidence: 99%

An Ultrasmall Fe₃O₄‐Decorated Polydopamine Hybrid Nanozyme Enables Continuous Conversion of Oxygen into Toxic Hydroxyl Radical via GSH‐Depleted Cascade Redox Reactions for Intensive Wound Disinfection

Xiao

Hai

et al. 2021

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Nanozyme‐based chemodynamic therapy (CDT) for fighting bacterial infections faces several major obstacles including low hydrogen peroxide (H2O2) level, over‐expressed glutathione (GSH) in infected sites, and inevitable damage to healthy tissue with abundant nonlocalized nanozymes. Herein, a smart ultrasmall Fe3O4‐decorated polydopamine (PDA/Fe3O4) hybrid nanozyme is demonstrated that continuously converts oxygen into highly toxic hydroxyl radical (•OH) via GSH‐depleted cascade redox reactions for CDT‐mediated bacterial elimination and intensive wound disinfection. In this system, photonic hyperthermia of PDA/Fe3O4 nanozymes can not only directly damage bacteria, but also improve the horseradish peroxidase‐like activity of Fe3O4 decorated for CDT. Surprisingly, through photothermal‐enhanced cascade catalytic reactions, PDA/Fe3O4 nanozymes can consume endogenous GSH for disrupting cellular redox homeostasis and simultaneously provide abundant H2O2 for improving •OH generation, ultimately enhancing the antibacterial performance of CDT. Such PDA/Fe3O4 can bind with bacterial cells, and reveals excellent antibacterial property against both Staphylococcus aureus and Escherichia coli. Most interestingly, PDA/Fe3O4 nanozymes can be strongly retained in infected sites by an external magnet for localized long‐term in vivo CDT and show minimal toxicity to healthy tissues and organs. This work presents an effective strategy to magnetically retain the therapeutic nanozymes in infected sites for highly efficient CDT with good biosafety.

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“…Recently, various metal oxides such as Fe 3 O 4 ( Fu et al, 2017 ), MnO 2 ( Liu et al, 2021 ), and CeO 2 ( Zhu et al, 2021 ) with significant pro-oxidative enzymatic activity have been utilized for therapeutic applications. Among different metal oxide–based nanozymes, Fe 3 O 4 nanoparticles (NP) received great attention owing to their excellent POD-like activity.…”

Section: Composite Nanozymes With Pro-oxidative Potentialmentioning

confidence: 99%

Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics

Maddheshiya

Nara

2022

Front. Bioeng. Biotechnol.

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Nanozymes are inorganic nanostructures whose enzyme mimic activities are increasingly explored in disease treatment, taking inspiration from natural enzymes. The catalytic ability of nanozymes to generate reactive oxygen species can be used for designing effective antimicrobials and antitumor therapeutics. In this context, composite nanozymes are advantageous, particularly because they integrate the properties of various nanomaterials to offer a single multifunctional platform combining photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT). Hence, recent years have witnessed great progress in engineering composite nanozymes for enhanced pro-oxidative activity that can be utilized in therapeutics. Therefore, the present review traverses over the newer strategies to design composite nanozymes as pro-oxidative therapeutics. It provides recent trends in the use of composite nanozymes as antibacterial, antibiofilm, and antitumor agents. This review also analyzes various challenges yet to be overcome by pro-oxidative composite nanozymes before being used in the field.

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NIR enhanced peroxidase-like activity of Au@CeO2 hybrid nanozyme by plasmon-induced hot electrons and photothermal effect for bacteria killing

Cited by 115 publications

References 50 publications

Efficient nanozyme engineering for antibacterial therapy

Efficient nanozyme engineering for antibacterial therapy

An Ultrasmall Fe₃O₄‐Decorated Polydopamine Hybrid Nanozyme Enables Continuous Conversion of Oxygen into Toxic Hydroxyl Radical via GSH‐Depleted Cascade Redox Reactions for Intensive Wound Disinfection

Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics

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NIR enhanced peroxidase-like activity of Au@CeO2 hybrid nanozyme by plasmon-induced hot electrons and photothermal effect for bacteria killing

Cited by 115 publications

References 50 publications

Efficient nanozyme engineering for antibacterial therapy

Efficient nanozyme engineering for antibacterial therapy

An Ultrasmall Fe3O4‐Decorated Polydopamine Hybrid Nanozyme Enables Continuous Conversion of Oxygen into Toxic Hydroxyl Radical via GSH‐Depleted Cascade Redox Reactions for Intensive Wound Disinfection

Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics

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An Ultrasmall Fe₃O₄‐Decorated Polydopamine Hybrid Nanozyme Enables Continuous Conversion of Oxygen into Toxic Hydroxyl Radical via GSH‐Depleted Cascade Redox Reactions for Intensive Wound Disinfection