NIR-driven polydopamine-based nanoenzymes as ROS scavengers to suppress osteoarthritis progression

Chen, Ying; Wang, Yonglin; Cai, Jinhong; Li, Kanglu; Huang, Hanji; Song, Fangming; Gao, Ming; Yang, Yuan; Zheng, Li; Zhao, Jinmin

doi:10.1016/j.mtnano.2022.100240

Cited by 22 publications

(18 citation statements)

References 42 publications

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“…Finally, the SOD kit was used to demonstrate the ability of Pt@ZIF-8@La to scavenge O 2– . Xanthine produces a superoxide anion in the xanthine oxidase reaction system, which could reduce nitroblue tetrazolium to generate blue formazan with a special UV–vis absorption peak at 560 nm.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, the SOD kit was used to demonstrate the ability of Pt@ZIF-8@La to scavenge O 2− . 27 Xanthine produces a superoxide anion in the xanthine oxidase reaction system, which could reduce nitroblue tetrazolium to generate blue formazan with a special UV−vis absorption peak at 560 nm. Different concentrations of Pt@ZIF-8@La were incubated with the SOD solution for 30 min, and follow-up operations were carried out according to the operating instructions of the SOD kit.…”

Section: Resultsmentioning

confidence: 99%

“…The superoxide anion (O 2– ) scavenging ability was assessed. The SOD enzyme assay kit (Solarbio) was used for evaluation . According to the operation manual, after the working solution was coincubated with different concentrations of Pt@ZIF-8@La at 37 °C for 30 min, the change of the absorption peak at 560 nm of the mixed solution was detected.…”

Section: Methodsmentioning

confidence: 99%

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Bimetallic Metal–Organic Framework for Mitigating Aseptic Osteolysis

Pan

Miao

Deng

et al. 2023

ACS Appl. Mater. Interfaces

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The disability rate of joint diseases can be reduced by the use of artificial joints, but joint loosening at a late state limits the lifespan and surgical efficacy of the joints. Wear particles can be recognized by macrophages and induce cells to produce reactive oxygen species (ROS) and inflammatory factors, causing persistent inflammation and decreased osteogenic activity, which ultimately leads to loosening of joint prostheses. Here, the platinum (Pt) nanozymes with excellent ROS scavenging and anti-inflammatory capabilities were encapsulated in zinc imidazolium zeolite framework-8 (ZIF-8), and then the osteogenic active element lanthanum (La) was introduced through ion exchange to finally construct a bimetallic metal−organic framework (Pt@ZIF-8@ La). In vitro and in vivo experiments demonstrated that this multifunctional nanoplatform possessed the functions of efficient scavenging of ROS, immune regulation, and promotion of osteogenic differentiation. Meanwhile, the mechanism is explored that Pt@ZIF-8@La can also promote osteogenic mineralization by upregulating the ratio of the osteoprotegerin (OPG)/receptor activator of the NF-κB ligand (RANKL), which can achieve a synergistic therapeutic effect of immunomodulation and osteogenesis, thereby realizing the purpose of relieving aseptic osteolysis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Bimetallic Metal–Organic Framework for Mitigating Aseptic Osteolysis

Pan

Miao

Deng

et al. 2023

ACS Appl. Mater. Interfaces

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“…Nec-1/PDA@Pt-Fe 3 O 4 showed considerable therapeutic quality apart from acting as a dual-mode imaging contrast agent. PDA, as the main material of this nanocomposite, is a good free radical scavenger because of its rich phenolic groups, which eliminates the ROS produced in inflammatory reactions [ 21 ]. Pt has a high catalase catalytic activity and can thus catalyze hydrogen peroxide and produce oxygen gas, which significantly improves the hypoxia microenvironment of LN and alleviate LN to a certain extent [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…Polydopamine (PDA) has become a subject of great interest in nanomedicine because of its excellent properties, including good biocompatibility, easy preparation, easy modification, and high near-infrared absorption [ 17 , 18 , 19 , 20 ]. In addition, PDA can be used as a free radical scavenger because of its rich phenolic groups and eliminates reactive oxygen species (ROS) produced in inflammatory reactions [ 21 , 22 ]. Moreover, PDA is an outstanding photoacoustic imaging contrast agent because of its strong absorption in the near-infrared region [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Polydopamine-Based Nanoparticles for Dual-Mode Imaging Guided Targeted Therapy of Lupus Nephritis

Wang

Han

et al. 2022

Pharmaceutics

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Lupus nephritis (LN) is a common and refractory inflammation of the kidneys caused by systemic lupus erythematosus. Diagnosis and therapies at this stage are inefficient or have severe side effects. In recent years, nanomedicines show great potential for imaging diagnosis and controlled drug release. Herein, we developed a polydopamine (PDA)-based nanocarrier modified with Fe3O4 and Pt nanoparticles and loaded with necrostatin-1 (Nec-1) for the bimodal imaging and therapy of LN. Results demonstrate that Nec-1/PDA@Pt-Fe3O4 nanocarrier exhibits good biocompatibility. Nec-1, as an inhibitor of receptor-interacting protein 1 kinase, can be used to inhibit receptor-interacting protein 1 kinase activity and then reduces inflammation due to LN. Experiments in vitro and in the LN mouse model confirmed that the nanocarrier can reduce neutrophil extracellular traps (NETs) production by RIPK1 and alleviate the progression of inflammation. Previous studies proved that Pt nanoparticles can catalyze H2O2 to produce oxygen. A blood oxygen graph of mouse photoacoustic tomography confirmed that Nec-1/PDA@Pt-Fe3O4 can generate oxygen to fight against the hypoxic microenvironment of LN. PDA and Fe3O4 are used as photographic developers for photoacoustic or magnetic resonance imaging. The preliminary imaging results support Nec-1/PDA@Pt-Fe3O4 potential for photoacoustic/magnetic resonance dual-mode imaging, which can accurately and non-invasively monitor microscopic changes due to diseases. Nec-1/PDA@Pt-Fe3O4 combining these advantages exhibited outstanding performance in LN imaging and therapy. This work offers valuable insights into LN diagnosis and therapy.

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PdZn/Co_SA‐NC Nanozymes with Highly Efficient SOD/CAT Activities for Treatment of Osteoarthritis via Regulating Immune Microenvironment

Yang,

Tan,

Guo

et al. 2024

Adv Funct Materials

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Inflammatory infiltration of synovial M1 macrophages, high levels of ROS, and NO exacerbate osteoarthritis (OA) progression. The PdZn/CoSA‐NC nanozymes, which are highly ordered PdZn intermetallic nanoparticles loaded with Co single atom N‐doped carbon‐rich in multi‐level pores, in an attempt to serve as SOD and CAT mimicking nanozymes for OA therapy is designed. The PdZn/CoSA‐NC nanozymes' high electron transfer and dual active site sufficient exposure enhances free radical adsorption and lower reaction energies, accelerating SOD‐like, CAT‐like, and GPx‐like catalyzed reactions, outperforming CoSA‐NC and PdZn/NC alone. Furthermore, PdZn/CoSA‐NC nanozymes exhibit favorable biocompatibility, reduce synovial macrophage oxidative stress in OA, alleviate hypoxia, restore mitochondrial function, regulate energy metabolism, increase antioxidant factors, and reduce inflammatory factors, thus effectively mitigating the progression of OA. Mechanistically, PdZn/CoSA‐NC nanozymes downregulate M1‐type phenotypic markers like IL‐1β by regulating purine metabolism. The PdZn/CoSA‐NC nanozymes offer a novel approach to treating oxidative stress‐related inflammatory diseases.

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NIR-driven polydopamine-based nanoenzymes as ROS scavengers to suppress osteoarthritis progression

Cited by 22 publications

References 42 publications

Bimetallic Metal–Organic Framework for Mitigating Aseptic Osteolysis

Bimetallic Metal–Organic Framework for Mitigating Aseptic Osteolysis

Multifunctional Polydopamine-Based Nanoparticles for Dual-Mode Imaging Guided Targeted Therapy of Lupus Nephritis

PdZn/Co_SA‐NC Nanozymes with Highly Efficient SOD/CAT Activities for Treatment of Osteoarthritis via Regulating Immune Microenvironment

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NIR-driven polydopamine-based nanoenzymes as ROS scavengers to suppress osteoarthritis progression

Cited by 22 publications

References 42 publications

Bimetallic Metal–Organic Framework for Mitigating Aseptic Osteolysis

Bimetallic Metal–Organic Framework for Mitigating Aseptic Osteolysis

Multifunctional Polydopamine-Based Nanoparticles for Dual-Mode Imaging Guided Targeted Therapy of Lupus Nephritis

PdZn/CoSA‐NC Nanozymes with Highly Efficient SOD/CAT Activities for Treatment of Osteoarthritis via Regulating Immune Microenvironment

Contact Info

Product

Resources

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PdZn/Co_SA‐NC Nanozymes with Highly Efficient SOD/CAT Activities for Treatment of Osteoarthritis via Regulating Immune Microenvironment