Nipple-sparing mastectomy for breast cancer close to the nipple: a single institution’s 11-year experience

Kim, Sunhyun; Lee, Seok-Won; Bae, Yong Chan; Lee, Seungju

doi:10.1007/s12282-020-01104-0

Cited by 13 publications

(9 citation statements)

References 36 publications

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“…Interestingly, at multivariate analysis, post-NACT Ki67 > 10% (hazard ratio, 4.245; 95% confidence interval, 1.865-9.663; p = 0.001) was found to be an independent risk factor for loco-regional recurrence and the only significant risk factor for NAC recurrence. In their study on 251 NSMs, Kim et al [90] described that the tumor-to-nipple distance was ≤2 cm in 47.4% and ≤1 cm in 27.5% of cases. Over a mean follow-up period of 68.0 months, they also described a loco-regional recurrence rate of 4.4% and an overall survival rate at 5 years of 98.0% in patients with invasive cancer and of 100% in patients with "in situ" disease.…”

Section: Conservative Mastectomymentioning

confidence: 98%

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Breast Cancer Surgery: New Issues

et al. 2021

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Since ancient times, breast cancer treatment has crucially relied on surgeons and clinicians making great efforts to find increasingly conservative approaches to cure the tumor. In the Halstedian era (mid-late 19th century), the predominant practice consisted of the radical and disfiguring removal of the breast, much to the detriment of women’s psycho-physical well-being. Thanks to enlightened scientists such as Professor Umberto Veronesi, breast cancer surgery has since impressively progressed and adopted a much more conservative approach. Over the last three decades, a better understanding of tumor biology and of its significant biomarkers has made the assessment of genetic and molecular profiles increasingly important. At the same time, neo-adjuvant treatments have been introduced, and great improvements in genetics, imaging technologies and in both oncological and reconstructive surgical techniques have been made. The future of breast cancer management must now rest on an ever more precise and targeted type of surgery that, through an increasingly multidisciplinary and personalized approach, can ensure oncological radicality while offering the best possible quality of life.

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Section: Conservative Mastectomymentioning

confidence: 98%

“…Indeed, several retrospective studies have demonstrated the oncological safety of NSM, reporting excellent outcome results and a very low local recurrence rate [86][87][88]. New guidelines aim at expanding the clinical applications of NSM, such as in the case of previous NACT [89] or of BC located close to the nipple [90].…”

Section: Conservative Mastectomymentioning

confidence: 99%

Breast Cancer Surgery: New Issues

et al. 2021

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“…Controversial issues include its use in locally advanced cases, the criterion for tumor-tonipple distance, the routine use of frozen section of the base of the nipple, the need for postmastectomy radiotherapy, and the thickness of the skin flap. [15][16][17][18][19] The primary objective of the present study was to evaluate the oncological outcomes of patients submitted to NSM in an unselected population seen at a single Brazilian institute.…”

Section: Introductionmentioning

confidence: 99%

“…Controversial issues include its use in locally advanced cases, the criterion for tumor-to-nipple distance, the routine use of frozen section of the base of the nipple, the need for postmastectomy radiotherapy, and the thickness of the skin flap. 15 16 17 18 19 …”

Section: Introductionmentioning

confidence: 99%

Oncological Outcomes of Nipple-Sparing Mastectomy in an Unselected Population Evaluated in a Single Center

Cavalcante

Araújo

Veras

et al. 2022

Rev Bras Ginecol Obstet

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Objective Nipple-sparing mastectomy (NSM) has been traditionally used in selected cases with tumor-to-nipple distance > 2 cm and negative frozen section of the base of the nipple. Recommending NSM in unselected populations remains controversial. The present study evaluated the oncological outcomes of patients submitted to NSM in an unselected population seen at a single center. Methods This retrospective cohort study included unselected patients with invasive carcinoma or ductal carcinoma in situ (DCIS) who underwent NSM in 2010 to 2020. The endpoints were locoregional recurrence, disease-free survival (DFS), and overall survival (OS), irrespective of tumor size or tumor-to-nipple distance. Results Seventy-six patients (mean age 46.1 years) (58 invasive carcinomas/18 DCIS) were included. The most invasive carcinomas were hormone-positive (60%) (HER2 overexpression: 24%; triple-negative: 16%), while 39% of DCIS were high-grade. Invasive carcinomas were T2 in 66% of cases, with axillary metastases in 38%. Surgical margins were all negative. All patients with invasive carcinoma received systemic treatment and 38% underwent radiotherapy. After a mean of 34.8 months, 3 patients with invasive carcinoma (5.1%) and 1 with DCIS (5.5%) had local recurrence. Two patients had distant metastasis and died during follow-up. The 5-year OS and DFS rates for invasive carcinoma were 98% and 83%, respectively. Conclusion In unselected cases, the 5-year oncological outcomes following NSM were found to be acceptable and comparable to previous reports. Further studies are required.

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“…Young et al avaliando 542 AMT, realizaram 42,8% das AMT em tumores de até 2,0 cm e 72,6% em pacientes com ausência de comprometimento linfonodal.Todavia, os autores demonstraram uma tendência ao aumento das indicações de radioterapia adjuvante ao longo dos anos 116. Kim et al119 , em um estudo retrospectivo com 11 anos de seguimento de AMT, apresentaram apenas 11 RLs, sendo que apenas uma (0,4%) foi no CAP, valor atribuído aos critérios de seleção bem estabelecidos como na pesquisa ora realizada. Outro estudo, realizado por Moo TA et.…”

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Adenectomia mamária para o tratamento do câncer de mama inicial: importância da avaliação da margem retroareolar e da remoção dos ductos intrapapilares

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Nipple-sparing mastectomy for breast cancer close to the nipple: a single institution’s 11-year experience

Cited by 13 publications

References 36 publications

Breast Cancer Surgery: New Issues

Breast Cancer Surgery: New Issues

Oncological Outcomes of Nipple-Sparing Mastectomy in an Unselected Population Evaluated in a Single Center

Adenectomia mamária para o tratamento do câncer de mama inicial: importância da avaliação da margem retroareolar e da remoção dos ductos intrapapilares

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