Niosomes as Nanocarrier Systems

Şahin, Nefise Özlen

doi:10.1007/978-1-4020-6289-6_4

Cited by 52 publications

(28 citation statements)

References 47 publications

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“…Niosomes are thermodynamically stable liposome-like vesicles produced with the hydration of cholesterol, charge-inducing components such as charged phospholipids (e.g., dicethylphosphate and stearyl amine) and nonionic surfactants (e.g., monoalkyl or dialkyl polyoxyethylene ether) [76]. They were conceived as alternative DDS that overcome a number of drawbacks shown by the liposomes, which were mainly associated with sterilization, high production costs, scale-up difficulties and the instability of the phospholipidic components after light exposure even at room temperature.…”

Section: Niosomesmentioning

confidence: 99%

Nanotechnology: A focus on Treatment of Tuberculosis.

Kumar¹,

Kumar²,

Kumar³

et al. 2011

Int J Drug Del

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Despite the fact that we live in an era of advanced technology and innovation, infectious diseases, like Tuberculosis (TB), continue to be one of the greatest health challenges worldwide. The main drawbacks of conventional TB treatment are the development of multiple drug resistance, resulting in high dose requirements and subsequent intolerable toxicity. Therefore there is a need of a new system have been receiving special attention with the aim of minimizing the side effects of drug therapy, such as poor bioavailability and the selectivity of drugs. Nanoparticle-based drug delivery systems have considerable potential for treatment of TB. The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility of variable routes of administration, including oral application and inhalation. Nanoparticles can also be designed to allow controlled (sustained) drug release from the matrix. These properties of nanoparticles enable improvement of drug bioavailability and reduction of the dosing frequency, and may resolve the problem of nonadherence to prescribed therapy, which is one of the major obstacles in the control of TB epidemics. In this review, we discuss the challenges with the current treatment of the disease and shed light on the remarkable potential of nanotechnology to provide more effective treatment and prevention for TB.

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Section: Niosomesmentioning

confidence: 99%

Nanotechnology: A focus on Treatment of Tuberculosis.

Kumar¹,

Kumar²,

Kumar³

et al. 2011

Int J Drug Del

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“…Vesicular delivery systems such as niosomes are reported to improve the dermal or topical delivery of various poorly soluble actives by enhancing solubility and permeability along with retention into the skin 19, 20, 21. Niosomes enhance the residence time of drugs in the stratum corneum and epidermis while reducing the systemic absorption of the drug 21, 22, 23.…”

Section: Introductionmentioning

confidence: 99%

Potentiating antimicrobial efficacy of propolis through niosomal-based system for administration

Patel

Ketkar

Patil

et al. 2015

Integrative Medicine Research

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BackgroundPropolis is a multicomponent active, complex resinous substance collected by honeybees (Apis mellifera) from a variety of plant sources. This study was designed to improve the antimicrobial efficacy of propolis by engineering a niosomal-based system for topical application.MethodsPropolis was extracted in ethanol and screened for total polyphenol content. Propolis-loaded niosomes (PLNs) were prepared with varying concentrations of Span 60 and cholesterol. The PLNs were evaluated for physicochemical parameters, namely, vesicle size, entrapment efficiency, zeta potential, surface topography and shape, and stability, followed by screening for in vitro antimicrobial activity. The PLNs were formulated into propolis niosomal gel (PNG) using Carbopol P934 base and subjected to ex vivo skin deposition study.ResultsThe ethanolic extract of propolis had high polyphenolic content (270 ± 9.2 mg GAE/g). The prepared PLNs showed vesicle size between 294 nm and 427 nm, and the percent entrapment in the range of 50.62–71.29% with a significant enhancement in antimicrobial activity against Staphylococcus aureus and Candida albicans. Enhanced antimicrobial activity of PLNs was attributed to the ability of niosomes to directly interact with the bacterial cell envelop thereby facilitating the diffusion of propolis constituents across the cell wall. The formulated PNG exhibited a twofold better skin deposition due to improved retention of niosomes in the skin.ConclusionThe findings indicate that the engineering of a niosomal-based system for propolis enhanced its antimicrobial potential through topical application.

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“…Niosom tersusun dari kolesterol dan surfaktan nonionik sebagai komponen utamanya. Surfaktan dengan nilai HLB antara 4 sampai 8 cenderung memiliki kemampuan untuk membentuk vesikel (Sahin, 2007). Span 60 merupakan surfaktan nonionik yang sering digunakan sebagai penyusun niosom dengan nilai HLB 4,7 (Rowe et al, 2009).…”

Section: Pendahuluanunclassified

In vitro penetration of alpha arbutin niosome span 60 system in gel preparation

Desnita

Luliana²,

Anggraini

2017

Pharmaciana

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ABSTRAKAlpha arbutin merupakan senyawa hidrofilik yang sulit melewati stratum korneum. Salah satu upaya dalam meningkatkan penetrasi obat melalui stratum korneum ialah dengan dibuat sistem niosom. Penelitian ini bertujuan mengetahui konsentrasi optimal span 60 dalam meningkatkan efisiensi penjeratan niosom dan mengetahui peningkatan penetrasi alpha arbutin dalam sediaan gel niosom secara in vitro. Niosom terdiri dari campuran span 60 dan kolesterol yang dibuat dengan metode hidrasi lapis tipis. Konsentrasi span 60 divariasikan dalam tiga formula yakni 100, 150 dan 200µmol. Sediaan gel dibuat dalam dua formula yaitu formula gel niosom alpha arbutin dan gel alpha arbutin. Uji efisiensi penjeratan menggunakan metode dialysis tubing cellulose membrane. Uji penetrasi secara in vitro menggunakan sel difusi franz tipe flow-trough dengan lepasan kulit ular. Hasil penentuan efisiensi penjeratan menunjukkan formula 100µmoL memiliki efisiensi penjeratan optimal yakni sebesar 99,09%±0,17. Hasil uji penetrasi secara in vitro dengan membran lepasan kulit ular menunjukkan penggunaan span 60 sebagai penyusun niosom dalam sediaan gel dapat meningkatkan penetrasi alpha arbutin dengan jumlah kumulatif persen difusi selama 8 jam sebesar 91,62% ± 2,32 dibandingkan gel alpha arbutin tanpa sistem niosom yakni sebesar 73,00% ±0,94.Kata kunci : niosom, alpha arbutin, span 60, penetrasi in vitro ABSTRACT Alpha arbutin is a hydrophilic compound which is difficult to pass trough the stratum corneum. One of the effort to increase the penetration of the drug through the stratum corneum is by making in niosome system. This study aims to determine the optimum concentration of span 60 to improve the entrapment efficiency of niosome and investigate the increasing penetration of alpha arbutin using the niosome system in the preparation of the gel in vitro. Niosome consist a mixture of span 60 and cholesterol it made by thin layer hydration method. Concentration of span 60 was varied into three formulas were 100, 150 and 200 µmoL. The formulation of gel was made in two formulas including formulation of niosome alpha arbutin and alpha arbutin in gel. The determination of enterapment efficiency showed that formula 100µmol has an optimum enterapment efficiency by 99.09%±0.17.

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Niosomes as Nanocarrier Systems

Cited by 52 publications

References 47 publications

Nanotechnology: A focus on Treatment of Tuberculosis.

Nanotechnology: A focus on Treatment of Tuberculosis.

Potentiating antimicrobial efficacy of propolis through niosomal-based system for administration

In vitro penetration of alpha arbutin niosome span 60 system in gel preparation

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