Niosomes as a Potential Drug Delivery System

Abstract

A non-ionic vesicle dependent on surfactants is a niosome. Niosomes are mainly formed as an excipient by non-ionic surfactant and cholesterol incorporation. Various excipients can also be used. Niosomes have a greater penetrating potential than previous emulsion preparations. There are various methods of manufacturing niosomes like thin film hydration, microfluidization, sonication, bubble method to name a few. The fact that niosomes are amphiphillic molecules makes them a flexible carrier of drugs, as both hydrophilic and lipophillic drugs can be trapped. Applications of niosomes in the pharmaceutical industry are many, some of the most important ones being as cosmoceuticals, gene delivery carriers, carriers for vaccine delivery and also in medical imaging. The main object of this review the appliance of niosome technology is employed to treat variety of diseases, niosome have good opportunity in research and beneficial for researcher and pharma industries. As niosome is stable and economical, niosome seems to be a well-preferred drug delivery mechanism over liposome.

Niosomes Versus Proniosomes as Promising Drug Delivery Systems in Treatment of Diabetes Mellitus

“…Cholesterol forms hydrogen bonds with hydrophilic surfactant heads in the bilayer structure of niosomes [19,53]. Therefore cholesterol content affects niosomes structure and physical properties such as entrapment efficiency (E. E %), long time stability [24,25].…”