Niosomes: a potential tool for novel drug delivery

Khan, Rizwana; Irchhaiya, Raghuveer

doi:10.1007/s40005-016-0249-9

Cited by 109 publications

(63 citation statements)

References 31 publications

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“…Liposomes are made up of two hydrophobic tails and may or may not contain cholesterol in the structure, whereas noisomes are nonionic surfactant‐based vesicles made up of single hydrophobic chain, which makes them eminently suitable as carrier molecules in drug delivery applications (Kazi et al . ; Khan and Irichhaiya ). Noisomes are constructed by hydration with or without the amalgamation of cholesterol or other lipids (Kazi et al .…”

Section: Health‐related Applicationsmentioning

confidence: 97%

“…MEL-A, a type of glycolipid biosurfactant that contains cationic liposomes has been shown to promote gene transfection efficiency by five to seven times with mammalian cultured cells (Inoh et al 2001). Liposomes are made up of two hydrophobic tails and may or may not contain cholesterol in the structure, whereas noisomes are nonionic surfactant-based vesicles made up of single hydrophobic chain, which makes them eminently suitable as carrier molecules in drug delivery applications (Kazi et al 2010;Khan and Irichhaiya 2016). Noisomes are constructed by hydration with or without the amalgamation of cholesterol or other lipids (Kazi et al 2010).…”

Section: Drug Delivery Systems Including Vaccinesmentioning

confidence: 99%

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Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

et al. 2019

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Synthetic surfactants are becoming increasingly unpopular in many applications due to previously disregarded effects on biological systems and this has led to a new focus on replacing such products with biosurfactants that are biodegradable and produced from renewal resources. Microbially derived biosurfactants have been investigated in numerous studies in areas including: increasing feed digestibility in an agricultural context, improving seed protection and fertility, plant pathogen control, antimicrobial activity, antibiofilm activity, wound healing and dermatological care, improved oral cavity care, drug delivery systems and anticancer treatments. The development of the potential of biosurfactants has been hindered somewhat by the myriad of approaches taken in their investigations, the focus on pathogens as source species and the costs associated with large‐scale production. Here, we focus on various microbial sources of biosurfactants and the current trends in terms of agricultural and biomedical applications.

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Section: Health‐related Applicationsmentioning

confidence: 97%

Section: Drug Delivery Systems Including Vaccinesmentioning

confidence: 99%

Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

et al. 2019

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“…Although there is a plethora of publications regarding non-ionic supramolecular assemblies [119,128], few data are available about their potential toxicity, especially long-term. Thorough metabolic studies on the fate of these surfactants should be performed if these assemblies have to realistically compete with phospholipid-based supramolecular systems towards biomedical applications.…”

Section: B Non-ionic Surfactantsmentioning

confidence: 99%

Molecular bionics – engineering biomaterials at the molecular level using biological principles

et al. 2019

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Life and biological units are the result of the supramolecular arrangement of many different types of molecules, all of them combined with exquisite precision to achieve specific functions. Taking inspiration from the design principles of nature allows engineering more efficient and compatible biomaterials. Indeed, bionic (from bion-, unit of life and -ic, like) materials have gained increasing attention in the last decades due to their ability to mimic some of the characteristics of nature systems, such as dynamism, selectivity, or signalling. However, there are still many challenges when it comes to their interaction with the human body, which hinder their further clinical development. Here we review some of the recent progress in the field of molecular bionics with the final aim of providing with design rules to ensure their stability in biological media as well as to engineer novel functionalities which enable navigating the human body.

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“…These niosomal dispersion are formed from self-assembly of hydrated synthetic non-ionic surfactant monomers which are capable of entrapping a wide variety of drugs both hydrophilic and hydrophobic, can be delivered by various routes like oral, transdermal, parenteral, occular [3] and have been considered superior to microspheres, nanoparticles, liposomes and other carriers in terms of better entrapment of drugs, better target site specificity and in handling burst effect of drug release [4,5]. Niosomes have also shown advantages as drug carriers, such as being low cost and chemically stable as compared to liposomes [6].…”

Section: Introductionmentioning

confidence: 99%

In Vitro in Vivo Evaluation of Niosomal Formulation of Famotidine

Khan

Irchhaiya

2020

Int J Pharm Pharm Sci

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Objective: The present study was aimed on formulation and evaluation of famotidine loaded niosomal formulation for in vitro and in vivo pharmacokinetic behaviour. Formulating it as niosomal formulation might be quite advantageous for prolonging the duration of pharmacological action and improved bioavailability. Methods:In the present study niosomal formulations were prepared by using most documented thin film hydration technique by using various grades of surfactants (span 20, 40, 60, 80) in varying ratios with cholesterol, negative charge inducer di cetyl phosphate (DCP) and drug famotidine. Suitable preformulation studies were conducted like identification of drug, excipient and drug compatibility study. The optimized drug loaded niosomes were characterized for size and morphology, polydispersity index, zeta potential, drug entrapment, in vitro release, in vivo study and stability study. Results:The results showed that the vesicles formed were spherical in shape, size ranging between 160.1 nm to 718.7 nm with zeta potential values indicating good stability and formulation containing span 60 (NMS7) showed the highest entrapment efficiency (73.234%). All the formulations showed prolonged release profile for more than 24 h with release kinetics better suited to zero order release pattern. In vivo study conducted on rabbits predicted a fourfold increase in pharmacokinetic parameter (area under curve)AUC and pharmacological action for more than 24 h as compared to free drug famotidine which showed its action only upto 12 h. Conclusion:Thus the famotidine loaded niosomal formulation may be considered as a very promising drug delivery system which could be successfully employed for prolonging the drug release and overcoming the drawbacks of conventional drug delivery systems.

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Niosomes: a potential tool for novel drug delivery

Cited by 109 publications

References 31 publications

Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

Microbial biosurfactants: current trends and applications in agricultural and biomedical industries

Molecular bionics – engineering biomaterials at the molecular level using biological principles

In Vitro in Vivo Evaluation of Niosomal Formulation of Famotidine

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