Niobium based coatings for dental implants

Ramirez, Giovanni; Rodil, S.E.; Arzate, Higinio; Mühl, S.; Olaya, Jhon J

doi:10.1016/j.apsusc.2010.10.021

Cited by 119 publications

(41 citation statements)

References 26 publications

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“…The biocompatibility was assessed by an in vitro model [20][21][22]; quantifying the adhesion, proliferation and viability of human osteoblasts cells in contact with the film surface in comparison with samples of medical grade stainless steel and tissue culture plastics, which represents the experimental optimum standard for investigations of osteoblast biology in vitro. Most probably, Nb thin films will not be the best material for real applications since Nb is considered a soft metal, but thin films based on Nb, such as Nb oxides or nitrides have a high potentiality, since they are hard, and wear and corrosion resistant [23,24]. Nevertheless, for biomedical applications, it is very important to determine the toxicity of the isolated elements as well as their compounds, since these may be released from the implant surface due to device corrosion or wear for example.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of Niobium Coatings

Olivares-Navarrete

Olaya²,

Ramírez

et al. 2011

Coatings

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Niobium coatings deposited by magnetron sputtering were evaluated as a possible surface modification for stainless steel (SS) substrates in biomedical implants. The Nb coatings were deposited on 15 mm diameter stainless steel substrates having an average surface roughness of 2 µm. To evaluate the biocompatibility of the coatings three different in vitro tests, using human alveolar bone derived cells, were performed: cellular adhesion, proliferation and viability. Stainless steel substrates and tissue culture plastic were also studied, in order to give comparative information. No toxic response was observed for any of the surfaces, indicating that the Nb coatings act as a biocompatible, bioinert material. Cell morphology was also studied by immune-fluorescence and the results confirmed the healthy state of the cells on the Nb surface. X-ray diffraction analysis of the coating shows that the film is polycrystalline with a body centered cubic structure. The surface composition and corrosion resistance of both the substrate and the Nb coating were also studied by X-ray photoelectron spectroscopy and potentiodynamic tests. Water contact angle measurements showed that the Nb surface is more hydrophobic than the SS substrate. OPEN ACCESSCoatings 2011, 1 73

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Section: Introductionmentioning

confidence: 99%

Biocompatibility of Niobium Coatings

Olivares-Navarrete

Olaya²,

Ramírez

et al. 2011

Coatings

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“…It has however been used in coatings of dental implants [12] and has been shown to be fully bioinert and biocompatible [13]. This, along with the presented analysis, suggests that Nb might be a suitable electrode material for LFP neural recordings.…”

Section: Resultsmentioning

confidence: 94%

Microwire-CMOS integration of mm-scale neural probes for chronic local field potential recording

Szostak

Mazza

Maslik

et al. 2017

2017 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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Abstract-This paper proposes a novel method for integrating CMOS microelectronics with microwire-based electrodes for next generation implantable brain machine interfaces. There is strong evidence to suggest that microwire-based electrodes outperform micromachined and polymer-based electrodes in terms of signal integrity and chronic viability. Furthermore, it has been shown that the recording of Local Field Potentials (LFPs) is more robust to tissue damage and scar tissue growth when compared to action potentials. This work therefore investigates the suitability of microwire electrodes for LFP recording by studying the electrical properties of key materials. We identify Niobium (Nb) as a candidate material with highly desirable properties. There is however also an inherent incompatibility when it comes to connection of microwire-based electrodes to silicon chips. Here we present a new process flow utilising a recessed glass substrate for mechanical support, silicon interposer for interconnection, and electroplating for contact adhesion. Furthermore, the proposed structure lends itself to hermetic encapsulation towards gas cavity based micropackages.

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“…However, because bioinert materials tend to be encapsulated in fibrous tissue after implantation, some sort of mechanical fixation is necessary to ensure the stability of the device. This step can be omitted when the surface of the implant is bioactive, which means that it can actively form a permanent fixation with treated bone [28,29]. To accomplish this goal, a wide variety of surface modification methods have been developed [29], including plasma spraying [30], glow discharge plasma treatment [31], ion implantation/deposition [32], physical vapour deposition, chemical vapour deposition, alkali treatment [33,34], sol-gel coatings [35] and electrochemical methods.…”

Section: Introductionmentioning

confidence: 99%

Modification of niobium surfaces using plasma electrolytic oxidation in silicate solutions

Sowa

Kazek-Kęsik

Krząkała

et al. 2013

J Solid State Electrochem

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Herein, a study of the plasma electrolytic oxidation (PEO) of niobium in an anodising bath composed of potassium silicate (K 2 SiO 3 ) and potassium hydroxide (KOH) is reported. The effects of the K 2 SiO 3 concentration in the bath and the process voltage on the characteristics of the obtained oxide layers were assessed. Compact, barrier-type oxide layers were obtained when the process voltage did not exceed the breakdown potential of the oxide layer. When this threshold was breached, the morphology of the oxide layer changed markedly, which is typical of PEO. A significant amount of silicon, in the form of amorphous silica, was incorporated into the oxide coatings under these conditions compared with the amount obtained with conventional anodising. This surface modification technique led to an improvement in the corrosion resistance of niobium in Ringer's solution, regardless of the imposed process conditions.

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Niobium based coatings for dental implants

Cited by 119 publications

References 26 publications

Biocompatibility of Niobium Coatings

Biocompatibility of Niobium Coatings

Microwire-CMOS integration of mm-scale neural probes for chronic local field potential recording

Modification of niobium surfaces using plasma electrolytic oxidation in silicate solutions

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