Nine-hole Peg Test and Ten-meter Walk Test for Evaluating Functional Loss in Chinese Charcot-Marie-Tooth Disease

Abstract

Background:The 9-hole peg test (9-HPT) and 10-meter walk test (10-MWT) are commonly used to test finger motor function and walking ability. The aim of this present study was to investigate the efficacy of these tests for evaluating functional loss in Chinese Charcot-Marie-Tooth (CMT) disease.Methods:Thirty-four Chinese CMT patients (CMT group) from August 2015 to December 2016 were evaluated with 9-HPT, 10-MWT, CMT disease examination score, overall neuropathy limitation scale (ONLS), functional disability score, and Berg Balance Scale (BBS). Thirty-five age- and gender-matched healthy controls (control group) were also included in the study. Student's nonpaired or paired t-test were performed to compare data between two independent or related groups, respectively. The Pearson test was used to examine the correlations between recorded parameters.Results:The mean 9-HPT completion time in the dominant hand of CMT patients was significantly slower than that in the healthy controls (29.60 ± 11.89 s vs. 19.58 ± 3.45 s; t = −4.728, P < 0.001). Women with CMT completed the 9-HPT significantly faster than men with CMT (dominant hand: 24.74 ± 7.93 s vs. 33.01 ± 13.14 s, t = 2.097, P = 0.044). The gait speed of the average self-selected velocity and the average fast-velocity assessed using 10-MWT for CMT patients were significantly slower than those in the control group (1.03 ± 0.18 m/s vs. 1.44 ± 0.17 m/s, t = 9.333, P < 0.001; 1.31 ± 0.30 m/s vs. 1.91 ± 0.25 m/s, t = 8.853, P < 0.001, respectively). There was no difference in gait speed between men and women. Both 9-HPT and 10-MWT were significantly correlated with the ONLS, functional disability score, and BBS (P < 0.05 for all).Conclusion:The 9-HPT and 10-MWT might be useful for functional assessment in Chinese patients with CMT.

Nine Hole Peg Test and Transcranial Magnetic Stimulation: Useful to Evaluate Dexterity of the Hand and Disease Progression in Amyotrophic Lateral Sclerosis

“…This suggests that the NHPT is a suitable tool to evaluate dexterity and progression in ALS patients. This is in line with previous studies of other diseases with involvement of upper or lower motor neurons that indicate that the NHPT is a suitable tool for patients with a primary involvement of the UMNs and LMNs [6–11]. In our study, we found a significant difference between ALS patients compared with controls using TMS.…”

“…Also, both measurements (TMS RMT and NHPT) were not combined before in a study. NHPT duration is a reliable tool that has been used in studies investigating diseases affecting UMNs and LMNs for years [6–11]. In this study, significantly longer NHPT durations were observed in patients compared with controls.…”

“…Since 1988, the test is used as an upper limb outcome measurement in multiple sclerosis, a disease with an involvement of the corticospinal tract [6]. In the last years, the NHPT could be assessed as a reliable test for dexterity in other diseases of the central nervous system such as stroke [7], traumatic brain injury [8], and cerebral palsy [9] but also for diseases with an involvement of the lower motor neurons as peripheral neuropathies [10, 11]. Transcranial magnetic stimulation (TMS) with resting-motor threshold (RMT) is a tool to show the involvement of the UMNs.…”

Methods of 10-Meter Walk Test and Repercussions for Reliability Obtained in Typically Developing Children

“…The 10MWT has measured locomotor capacities in adults [5,6] and children [7][8][9][10][11] with several neuromotor diseases. However, the operational procedures can influence the outcome of the 10MWT, as shown in adults [12,13].…”

The value of MUNIX as an objective electrophysiological biomarker of disease progression in chronic inflammatory demyelinating polyneuropathy

“…MUNIX, EDx, clinical outcome measures, including MRCSS, ONLS, R-ODS, Jamar handgrip dynamometry, timed 10-meter walk test (10MWT), pinch power test, and nine-hole peg test (NHPT), were performed at baseline and after 6 months, according to previously validated and published protocols. [17][18][19] Manual muscle testing was used to measure the muscle strength bilaterally according to the MRCSS (ranging from 0 to 60 points) for shoulder abduction, elbow flexion, wrist extension in upper extremities and hip flexion, knee extension, and ankle dorsiflexion in the lower extremities.…”