Nine-fold higher risk of acute myocardial infarction in subjects with type 1 diabetes compared to controls in Norway 1973–2017

Saeed, Muhammad; Stene, Lars C.; Ariansen, Inger; Tell, Grethe S.; Tapia, German; Joner, Geir; Skrivarhaug, Torild

doi:10.1186/s12933-022-01498-5

Cited by 8 publications

(10 citation statements)

References 47 publications

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“…The following strengths should, however, be emphasized. Foremost, to the best of our knowledge, except Saeed et al, [ 44 ] this study is the longest population-based study of non-fatal MI and fatal MI time trends (32 years). Secondly, our analysis used valid data from a well-organized population-based registry with an established algorithm for recording nearly all MIs in the study region.…”

Section: Discussionmentioning

confidence: 98%

Sex-specific trends in incidence of first myocardial infarction among people with and without diabetes between 1985 and 2016 in a German region

Claessen,

Narres,

Heier

et al. 2024

Cardiovasc Diabetol

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Background The reduction of myocardial infarction (MI) and narrowing the gap between the populations with and without diabetes are important goals of diabetes care. We analyzed time trends for sex-specific incidence rates (IR) of first MI (both non-fatal MI and fatal MI) as well as separately for first non-fatal MI and fatal MI in the population with and without diabetes. Methods Using data from the KORA myocardial infarction registry (Augsburg, Germany), we estimated age-adjusted IR in people with and without diabetes, corresponding relative risks (RR), and time trends from 1985 to 2016 using Poisson regression. Results There were 19,683 people with first MI (34% fatal MI, 71% men, 30% with diabetes) between 1985 and 2016. In the entire study population, the IR of first MI decreased from 359 (95% CI: 345–374) to 236 (226–245) per 100,000 person years. In men with diabetes, IR decreased only in 2013–2016. This was due to first non-fatal MI, where IR in men with diabetes increased until 2009–2012, and slightly decreased in 2013–2016. Overall, fatal MI declined stronger than first non-fatal MI corresponding to IRs. The RR of first MI substantially increased among men from 1.40 (1.22–1.61) in 1985–1988 to 2.60 (2.26–2.99) in 1997–2000 and moderately decreased in 2013–2016: RR: 1.75 (1.47–2.09). Among women no consistent time trend for RR was observed. Time trends for RR were similar regarding first non-fatal MI and fatal MI. Conclusions Over the study period, we found a decreased incidence of first MI and fatal MI in the entire study population. The initial increase of first non-fatal MI in men with diabetes needs further research. The gap between populations with and without diabetes remained.

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Section: Discussionmentioning

confidence: 98%

Sex-specific trends in incidence of first myocardial infarction among people with and without diabetes between 1985 and 2016 in a German region

Claessen,

Narres,

Heier

et al. 2024

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…The following strengths should, however, be emphasized. Foremost, to the best of our knowledge, except Saeed et al, [30] this study is the longest population-based study of non-fatal MI and fatal event time trends (32 years). Secondly, our analysis used valid data from a well-organized population-based registry with an established algorithm for recording nearly all MIs in the study region.…”

Section: Limitations Strengthsmentioning

confidence: 89%

Sex-specific trends in incidence of myocardial infarction among people with and without diabetes between 1985 and 2016 in a German region

Claessen,

Narres,

Heier

et al. 2023

Preprint

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Background The reduction of myocardial infarction (MI) and narrowing the gap between the populations with and without diabetes are important goals of diabetes care. We analyzed time trends of sex-specific incidence rates (IR) of first MI (all, non-fatal MI, fatal event) in the population with and without diabetes. Methods Using data from the KORA myocardial infarction registry (Augsburg, Germany), we estimated age-adjusted IR in people with and without diabetes, corresponding relative risks (RR), and time trends from 1985 to 2016 using Poisson regression. Results There were 19,683 people with MI (34% fatal events, 71% men, 30% with diabetes). In the entire study population, the IR of all MI decreased from 359(95% CI: 345–374) to 236(226–245) per 100,000 person years. In men with diabetes, IR decreased only in 2013–2016. This was due to non-fatal MI, where IR in men with diabetes increased until 2009–2012, and slightly decreased in 2013–2016. Overall, fatal events declined stronger than non-fatal MI corresponding to IRs, the relative risk (RR) of all MI substantially increased among men from 1.40(1.22–1.61) in 1985–1988 to 2.60(2.26–2.99) in 1997–2000 and moderately decreased in 2013–2016: RR: 1.75(1.47–2.09). Among women no consistent time trend of RR was observed. Time trends of RR were similar regarding non-fatal MI and fatal events. Conclusions Over the study period, we found a decreased incidence of all MIs and fatal events in the entire study population. The initial increase of non-fatal MIs in men with diabetes needs further research. The gap between populations with and without diabetes remained.

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“…Smoking, hypertension, hyperlipidemia, inflammation caused by oxidative stress, apoptosis, vascular remodeling, plaque stress, blood-flow shear stress, and diabetes mellitus are all risk factors for ACS [39,40]. Moreover, Yao et al (2021) hypothesized that inflammation and a family history of high cholesterol burden, which begins at a young age, are linked to CAD severity [41].…”

Section: Discussionmentioning

confidence: 99%

Various Expressions of PIK3C2A and TXNIP Genes and Their Potential Role as Independent Risk Factors for Chronic Stable Angina and Acute Coronary Syndrome

et al. 2023

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Background and Aim: Genetic factors play a significant role in the onset and progression of coronary artery disease (CAD). PIK3C2A may contribute to the development of acute coronary syndrome (ACS) by affecting blood glucose levels and oxidative stress. The expression levels of TXNIP were significantly higher in patients with unstable angina pectoris. However, the situation is different in ACS. In the current study, we aim to investigate the role of PIK3C2A and TXNIP as independent risk factors for chronic stable angina (CSA) and ACS. Subjects and Methods: This study involved 215 subjects (60 patients with CSA, 55 patients with ACS, and 100 controls). All subjects were exposed for assaying gene expressions of PIK3C2A and TXNIP by quantitative real-time polymerase chain reaction. Results: It was found that TXNIP was upregulated, whereas PIK3C2A was downregulated in patients with CAD compared to the control group. PIK3C2A was significantly downregulated in patients with ACS compared to that in patients with CSA (p < 0.001), but TXNIP was not (p = 0.7). TXNIP was significantly upregulated in STEMI-ACS patients compared to CSA (p = 0.045) and NSTEMI ACS (p = 0.046), among non-diabetic (p = 0.023) smokers (p = 0.036) with hypertension (p = 0.005) and hypercholesterolemia (p = 0.001). ROC (receiver operating characteristic) curve analysis revealed that PIK3C2A (0.981; p < 0.001; 98.18) was the most sensitive mRNA for discriminating ACS from control, followed by TXNIP (0.775; p < 0.001; 70.91). However, for discriminating ACS from CSA combined mRNAs, (PIK3C2A + TXNIP) (0.893; p < 0.001; 98.18) and PIK3C2A (0.892; p < 0.001; 81.82) are promising biomarkers. On the other hand, the most sensitive mRNA for differentiating CSA from control is mRNAs (PIK3C2A + TXNIP) (0.963; p < 0.001; 95), then TXINP (81.3; p < 0.001; 93.33), and finally, PIK3C2A (0.782; p < 0.001; 81.67). In the multivariate regression model, PIK3C2A ((p = 0.002), 0.118 (0.031–0.445)) and smoking status ((p = 0.034); 0.151 (0.026–0.866)) were independent variables for ACS. Moreover, PIK3C2A ((p < 0.013); 0.706 (0.614–0.812)), Hb ((p = 0.013); 0.525 (0.317–0.871)), and total cholesterol ((p = 0.04); 0.865 (0.784–0.955)) were significantly (p < 0.05) and independently related to the prognosis of CSA. Furthermore, PIK3C2A ((p = 0.002), 0.923 (0.877–0.971)), TXNIP ((p = 0.001); 2.809 (1.558–5.064)) the body weight ((p = 0.033); 1.254 (1.018–1.544)) were independently associated with CSA. Conclusions: Our study concluded that the dysregulated mRNA PIK3C2A and TXNIP gene expressions may be useful in diagnosis of CAD and prediction of ACS development.

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Nine-fold higher risk of acute myocardial infarction in subjects with type 1 diabetes compared to controls in Norway 1973–2017

Cited by 8 publications

References 47 publications

Sex-specific trends in incidence of first myocardial infarction among people with and without diabetes between 1985 and 2016 in a German region

Sex-specific trends in incidence of first myocardial infarction among people with and without diabetes between 1985 and 2016 in a German region

Sex-specific trends in incidence of myocardial infarction among people with and without diabetes between 1985 and 2016 in a German region

Various Expressions of PIK3C2A and TXNIP Genes and Their Potential Role as Independent Risk Factors for Chronic Stable Angina and Acute Coronary Syndrome

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