Nikkomycin quantitation in fermentation process by high-performance liquid chromatography

Fiedler, H.-P.; Kurth, Ralf; Dehler, W.

doi:10.1007/bf00127399

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1987

1998

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“…Fiedler (Tubingen University, FRG). The concentration of various nikkomycins in the fermentation broth of S. tendae was determined spectrophotometrically, following separation on a RP18 (Merck) column (Fiedler et al 1981;Fiedler 1984). The biological activity of nikkomycins was determined by chitin synthase inhibition assay, as described by Furter & Rast (1985).…”

Section: Methodsmentioning

confidence: 99%

Fermentation broth of Bacillus thuringiensis as a source of precursors for production of nikkomycins

Vecht-Lifshitz

Braun

1989

Lett Appl Microbiol

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Production of nikkomycins (nucleoside antibiotics inhibiting chitin synthesis) byStreptomyces tendae (ATCC 31 160) was considerably enhanced by addition of fermentation wastes of Bacillus thuringiensis var. kurstaki (HD 263) to the basal soymannitol medium. Analysis of this fermentation broth for nucleic acid derivatives showed that they contained about 0.8 g/l of various nucleosides and bases (uracil 0.43 g/l; hypoxanthine 0.21 g/l; as well as uridine, cytosine and adenine).

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Section: Methodsmentioning

confidence: 99%