Carbohydrates

Collins, Peter

doi:10.1007/978-1-4899-3382-9_1

Cited by 7 publications

(2 citation statements)

References 4,878 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, melting transitions were only observed in the presence of sodium taurocholate (SD-2 and FD-2), where melting occurred at 150-160°C. The melting temperature observed corresponds to the melting point of melezitose dihydrate (153°C) (Collins, 1987). Reference samples of melezitose show a melting peak at 160°C, which is due to the dihydrate form.…”

Section: Morphologymentioning

confidence: 97%

See 1 more Smart Citation

The Stability of Insulin in Solid Formulations Containing Melezitose and Starch. Effects of Processing and Excipients

Mollmann

Bukrinsky

Elofsson³

et al. 2006

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

Solid insulin formulations obtained by different methods of preparation were compared with respect to chemical stability and morphology. Spray- and freeze-drying, solution enhanced dispersion by supercritical fluids (SEDS) and precipitation into starch microspheres were the methods used for preparation of solid powders. The excipients applied were melezitose, starch, and sodium taurocholate. The stability of the samples was evaluated after storage in open containers at 25 degrees C and 30% RH for 6 months. All samples were amorphous after processing and storage as detected by XRD, except for the starch microspheres which were semi-crystalline. The spray- and freeze-dried samples containing melezitose and sodium taurocholate experienced a significant water uptake during storage, resulting in changes in morphology and disappearance of Tg. However, the chemical stability of these samples did not seem to be affected by the water uptake. Changes in morphology were not observed for the SEDS powders and the starch microspheres. The chemical stability of the samples was assessed by HPLC. In general, conventional spray- and freeze drying resulted in samples with higher chemical stability compared to SEDS powders and starch microspheres. Nevertheless, the excipients applied were observed to be of major importance, and further optimization of the formulation as well as processing conditions may lead to slightly different conclusions.

show abstract

Section: Morphologymentioning

confidence: 97%

“…Sodium taurocholate may act as an absorption enhancer in pulmonary delivery of insulin (Johansson, 2002) and was included in the formulations obtained by SEDS as well as spray-and freeze-dried powder. Furthermore, sodium taurocholate is a surfactant and can potentially stabilize insulin against surface adsorption (Collins, 1987).…”

Section: Introductionmentioning

confidence: 99%

The Stability of Insulin in Solid Formulations Containing Melezitose and Starch. Effects of Processing and Excipients

Mollmann

Bukrinsky

Elofsson³

et al. 2006

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

show abstract

Conversion of d-xylose to protected d-lyxose derivatives and to d-lyxose, via the corresponding 1,2-anhydride

Popsavin

Grabež

Stojanović³

et al. 1999

Carbohydrate Research

View full text Add to dashboard Cite

Radical Trifluoromethylation of a d-Mannose Derived Ketene Dithioacetal. Synthesis of 2-C-Trifluoromethyl Derivatives of d-glycero-d-galacto- and d-glycero-d-talo-Heptopyranose

1997

View full text Add to dashboard Cite

Diacetone D-mannose was converted into ketene dithioacetals 3 by a Peterson reaction with 2-lithio-2-(trimethylsilyl)-1,3-dithiane or lithiobis(methylsulfanyl)(trimethylsilyl)methane. Radical addition of trifluoromethyl bromide (iodide) induced by electron transfer (from sulfoxylate radical anion) led selectively to a dithioketalized 2-deoxy-2-C-(trifluoromethyl)-D-glycero-D-galacto-heptopyranolactone (5a) or to the corresponding dithioketalized open sugar 9, mainly according to the alkylsulfanyl group. Reaction conditions were found for complete or partial dethioketalization of these intermediates. A diisopropylidene-protected 2-deoxy-2-C-(trifluoromethyl)-D-glycero-D-taloheptopyranolactone (12) was obtained from 5a, with concomitant epimerization of C-2. Compound 9 was converted into either the corresponding sugar 14 or its methyl thioglycoside 13. Most of these reactions gave preparative yields, and the overall sequence constitutes a three-step synthesis of 2-deoxy-2-C-(trifluoromethyl)-D-glycero-D-galacto-heptose or D-talo-heptose derivatives.

show abstract

Carbohydrates

Cited by 7 publications

References 4,878 publications

The Stability of Insulin in Solid Formulations Containing Melezitose and Starch. Effects of Processing and Excipients

The Stability of Insulin in Solid Formulations Containing Melezitose and Starch. Effects of Processing and Excipients

Conversion of d-xylose to protected d-lyxose derivatives and to d-lyxose, via the corresponding 1,2-anhydride

Radical Trifluoromethylation of a d-Mannose Derived Ketene Dithioacetal. Synthesis of 2-C-Trifluoromethyl Derivatives of d-glycero-d-galacto- and d-glycero-d-talo-Heptopyranose

Contact Info

Product

Resources

About