Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver

Yıldız, Fahrettin; Çoban, Sacit; Terzi, Alpaslan; Ateş, Mustafa; Aksoy, Nurten; Çakır, Hale; Ocak, Ali Rıza; Bıtıren, Muharrem

doi:10.3748/wjg.14.5204

Cited by 83 publications

(61 citation statements)

References 32 publications

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“…Biochemical parameters like the serum aspartate aminotransferase, alanine aminotransferase lactate dehydrogenase levels and total antioxidant capacity (TAC), CAT, total oxidative status (TOS), oxidative stress index (OSI) and MPO were determined in hepatic tissue in rats with hepatic ischemia. Results suggested that N. sativa treatment protects the rat liver against hepatic ischemia reperfusion injury [86] . N. sativa administration protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride [52] .…”

Section: Hepato-protective Activitymentioning

confidence: 91%

A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,086

796

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Section: Hepato-protective Activitymentioning

confidence: 91%

A review on therapeutic potential of Nigella sativa: A miracle herb

Ahmad

Husain

Mujeeb

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

1,086

796

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“…The polymer is far less toxic but retains much of the pharmacologic properties of TQ, which is the active principle of the plant. The pharmacological actions of the seeds of Nigella sativa or its constituents that have been reported include protection against nephrotoxicity and hepatotoxicity induced by either disease or chemicals [6][7][8][9][10][11][12][13][14]. The seeds/oil have anti-inflammatory [15], analgesic [4], antipyretic [16], spasmolytic [17], bronchodialator [17], antihistaminic [18], antihypertensive [19], antitumor [20], antioxidant [18], antineoplastic [9,21,22], antifertility [23], antibacterial [24], antifungal [25], antiprotozoal [26], anthelmintic [27] and insecticidal [28] activities.…”

Section: Review and Discussionmentioning

confidence: 99%

Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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Seeds of Nigella sativa (black cumin/kalonji) used in pickles as spice, have also been traditionally used in treatment of many diseases including diabetes and hypertension. Among many activities exhibited by N. sativa and its constituents in animal experiments, antidiabetic property is most important. Thymoquinone (TQ), a volatile oil, is one of its active constituents but antidiabetic activity has also been shown by its aqueous extract and defatted extract. N. sativa may be beneficial in diabetic individuals and those with glucose intolerance as it reduces appetite, glucose absorption in intestine, hepatic gluconeogenesis, blood glucose level, cholesterol, triglycerides, body weight and simulates glucose induced secretion of insulin from beta-cells in pancreas; improves glucose tolerance as efficiently as metformin; yet it has not shown significant adverse effects and has very low toxicity. In streptozotocin (STZ) induced diabetic rats it causes gradual partial regeneration of pancreatic beta-cells, increases the lowered serum insulin concentrations and decreases the elevated serum glucose. N. sativa has antioxidant activity and protective role of TQ against development of type I diabetes may be via NO inhibitory pathway. It also exerts an insulin-sensitizing action in hepatocytes. Seeds of N. sativa have been safely consumed by human patients in many clinical trials which however were not aimed to assess its antidiabetic activity. In future clinical studies may show potential of N. sativa, its constituents or their synthetic analogues, in prevention and control of diabetes.

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“…Daha önce yapılan çalışmalar İ/R modelinde TOS dü-zeylerinin arttığını göstermiştir [22,23]. Çalışmamızda da İ/R grubunun TOS değerleri sham grubuna göre İskemi/reperfüzyon hasarında artmış oksidatif stres sonucu proteinlerin sekonder ve tersiyer yapılarında oluşan değişiklikler fonksiyonlarını etkilemektedir [25].…”

Section: Discussionunclassified