Nigella sativa L.: Uses in traditional and contemporary medicines – An overview

Majeed, Abdul; Muhammad, Zahir; Ahmad, Habib; Ullah, Rehan; Hayat, Sayed Sardar Sikandar; Inayat, Naila; Siyyar, Saira

doi:10.1016/j.chnaes.2020.02.001

Cited by 58 publications

(32 citation statements)

References 72 publications

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“…Active ingredients of N. sativa reported in several studies are dithymoquinone (DTQ), thymoquinone (TQ), thymol, thymohydroquinone (THQ), p-cymene, 4-terpineol, and t-anethole. N. sativa seeds also contain other ingredients such as vitamins, mineral elements, carbohydrates, fats, proteins, and essential amino acids (Ahmad et al, 2013;Al-Jassir, 1992;Bhatia & Bajaj, 1972;Chun et al, 2002;Correa et al, 1986;Islam et al, 2019;Majeed et al, 2020;Omar et al, 1999). Bioactive compounds used in the current study are shown in Figure 1.…”

Section: Nigella Sativa and Derived Compoundsmentioning

confidence: 99%

“…Nigella sativa, a herbal medicine belonging to the Ranunculaceae family, has been explored exclusively and acquired worldwide acknowledgment as a proven historical and religious remedy for a wide range of health problems (Goreja, 2003). N. sativa seeds have been consumed to treat various diseases and infirmities (Begum & Mannan, 2020;Majeed et al, 2020;Yimer et al, 2019). In Islamic as well as Christian literature it is considered as one of the best curing medicine.…”

Section: Introductionmentioning

confidence: 99%

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Molecular docking, simulation and MM-PBSA studies of nigella sativa compounds: a computational quest to identify potential natural antiviral for COVID-19 treatment

Ahmad

Abbasi

Shahid

et al. 2020

Journal of Biomolecular Structure and Dynamics

107

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Nigella sativa or black seed is used as a medicinal plant around the globe. Oil and seeds have a long tradition of folklore use in various medicinal and food systems. The conventional therapeutic use of Nigella sativa, in different ways, has been reported in several studies to treat different diseases including influenza, headache, hypertension, diabetes, inflammation, eczema, fever, cough, asthma, bronchitis, and fever. Based on previously reported potential therapeutic uses of N. sativa compounds, and keeping in mind the dire need of time for the development of potent antiviral, a combined docking, ADMET properties calculation, molecular dynamics, and MM-PBSA approaches were applied in the current study to check the therapeutic potentials of N. sativa chief constituents against COVID-19. Among the studied compounds, we found that dithymoquinone (DTQ), with binding affinity of À8.6 kcal/mol compared to a positive control (chloroquine, À7.2 kcal/mol) , has the high potential of binding at SARS-CoV-2:ACE2 interface and thus could be predicted as a plausible inhibitor to disrupt viral-host interactions. Molecular dynamics simulation of 100 ns well complemented binding affinity of the compound and revealed strong stability of DTQ at the docked site. Additionally, MM-PBSA also affirms the docking results. Compound DTQ of the present study, if validated in wet lab experiments, could be used to treat COVID-19 and could serve as a lead in the future for development of more effective natural antivirals against COVID-19.

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Section: Nigella Sativa and Derived Compoundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular docking, simulation and MM-PBSA studies of nigella sativa compounds: a computational quest to identify potential natural antiviral for COVID-19 treatment

Ahmad

Abbasi

Shahid

et al. 2020

Journal of Biomolecular Structure and Dynamics

107

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“…The seeds contain 40% fixed oil and about 1.4% essential oil and are medicinally used as carminative, cathartic, milk-promoter, anti-constipation, and sexual promoter in men. Although it is a wild species, it is cultivated in some parts of Europe, Eastern Asia, and some regions of Iran 8 , 9 . The biofertilizer Azotobarvar-1 (containing nitrogen-fixing bacteria from the genus Azotobacter ) is a voluntary molecular nitrogen fixer that is capable of synthesizing biologically active compounds in the root zone including nicotinic acid, pantothenic acid, biotin, vitamin B, auxins, and gibberellins 10 .…”

Section: Introductionmentioning

confidence: 99%

Combined bio-chemical fertilizers ameliorate agro-biochemical attributes of black cumin (Nigella sativa L.)

Moradzadeh

Moghaddam

Rahimi

et al. 2021

Sci Rep

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Nigella sativa L. is a medicinal plant with extensive, nutritional, pharmaceutical, and health applications. Nowadays, reducing the application of chemical fertilizers (synthetic fertilizers) is one of the main goals of sustainable agriculture to allow the production of safe crops. Therefore, the combined effect of urea and biofertilizers was studied on the quantitative and qualitative traits of N. sativa L. in a randomized complete block design with 10 treatments and three replications. The treatments included control (no fertilization), U (100% chemical fertilizer as urea at 53.3 kg ha−1, Nb (Biofertilizer, Azotobacter vinelandii), Pb (Biofertilizer, Pantoea agglomerans and Pseudomonas putida), Kb (Biofertilizer, Bacillus spp.), NPKb (NPK, biofertilizer), Nb + 50% U, Pb + 50% U, Kb + 50%U and NPKb + 50% U. The NPK(b) + U50% was related to the highest quantity of plant height, branch diameter, capsule (follicle) number per plant, auxiliary branches, seed yield per plant, thousand-seed weight, essential oil content, total phenolic compounds, flavonoid content, DPPH free radical scavenging, nitric oxide (NO) radical scavenging, superoxide radical scavenging, chain-breaking activity, phosphorus content, and potassium content, along with U for the highest biological yield and (Pb) + U50% for the highest essential oil percentage which is close to (NPKb) + U50%. The lowest value was observed in all traits related to the control treatment except for branch diameter that was related to (NPKb). Hence, the application of (NPKb) + U50% as bio-chemical fertilizers improved N. sativa L. Traits, so it can be recommended.

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“…Nigella sativa L. is an annual herbaceous plant from the Ranunculaceae family. In Middle Eastern folk medicine, it has usually been employed traditionally as a natural remedy to treat different diseases for almost 2,000 years (Majeed et al, 2020). N. sativa oil (NSO) is considered as one of the functional oils because it can function as a rich source of natural antioxidants due to the rich content of thymoquinone (Mohammed, Meor Hussin, Tan, Abdul Manap, & Alhelli, 2017).…”

Section: Introductionmentioning

confidence: 99%

Influence of different combinations of wall materials on encapsulation of Nigella sativa oil by spray dryer

Mohammed

Alhelli

Hussin

2021

J Food Process Engineering

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This study aimed to characterize six combinations of wall materials including maltodextrin (MD)/lactose (LAC) with Arabic gum (AG), sodium caseinate (SC) and whey protein concentrate to encapsulate Nigella sativa oil (NSO). The droplet size, viscosity and emulsion stability of NSO emulsion were evaluated. The encapsulated powders were characterized and microencapsulation efficiency (MEE), and morphology were evaluated. All the emulsions showed stability over the tested time with highest viscosity for MD‐AG and larger droplet size was for LAC‐SC blends. The highest MEE was obtained for MD‐SC was the 92.46% and lowest value for LAC‐AG was 68.42%. Moreover, the MD‐SC showed best solubility of 93.33% with the lowest moisture content of 1.63% while the moisture content for LAC‐AG was 2.06%. MD blends had smaller particle sizes ranged from 13.88 to 19.02 μm. with smooth surfaces and spherical shapes. This study revealed that all blends contained MD showed better properties than LAC. Practical applications This study developed an encapsulation of Nigella sativa oil by using spray dryer technology using different types of wall materials to ensure the appropriate one based on the findings regarding the physicochemical properties. The encapsulated Nigella sativa oil can be used as an alternative for the chemical antioxidants in the market, their consumption can reduce the oxidation activity in the body. The active compound in the oil is believed to have strong biological activities. In addition, the technology used in this study can be applied to other types of oils and essential oils.

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Nigella sativa L.: Uses in traditional and contemporary medicines – An overview

Cited by 58 publications

References 72 publications

Molecular docking, simulation and MM-PBSA studies of nigella sativa compounds: a computational quest to identify potential natural antiviral for COVID-19 treatment

Molecular docking, simulation and MM-PBSA studies of nigella sativa compounds: a computational quest to identify potential natural antiviral for COVID-19 treatment

Combined bio-chemical fertilizers ameliorate agro-biochemical attributes of black cumin (Nigella sativa L.)

Influence of different combinations of wall materials on encapsulation of Nigella sativa oil by spray dryer

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