Nigella sativa as a promising intervention for metabolic and inflammatory disorders in obese prediabetic subjects: A comparative study of Nigella sativa versus both lifestyle modification and metformin

Nigella sativa supplementation improves cardiometabolic indicators in population with prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

“…All the included trials had parallel designs and were published between 2012 and 2022. These studies were carried out in Iran ( 19 , 21 , 37 , 41 , 43 , 45 , 46 ), India ( 40 , 44 ), Egypt ( 20 ), and Saudi Arabia ( 42 ). In total, 666 participants (338 interventions and 328 controls) were recruited with the age range between 42.9 ± 3.2 and 56 ± 3.4 years old and the BMI range between 26.79 ± 2.94 and 33.90 ± 2.10 kg/m 2 .…”

“…Nine studies included both genders, whereas two studies were performed exclusively on females ( 19 , 45 ). All the participants were individuals with T2DM except one study including those with prediabetes ( 20 ). The dose of N. sativa supplementation ranged from 0.9 to 5 g/day, with the length of follow-up ranging from 2 to 6 months throughout the studies.…”

“…Numerous studies proposed N. sativa as an adjuvant therapy in diabetes control, since it revealed a significant reduction in glucose values following oral glucose tolerance test (OGTT), fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) levels, and insulin resistance, and also an escalation in serum fasting insulin concentrations ( 18 – 20 ), while recent research reported that N. sativa supplementation increased the levels of glycemic control components ( 21 ). Furthermore, it has been demonstrated that N. Sativa extract could increase the high-density lipoprotein cholesterol (HDL-C) concentration through rising the activity of plasma lecithin cholesterol acetyltransferase (LCAT), and it could also exert its antioxidant effects by enhancing the activities of antioxidant enzymes, including catalase and glutathione peroxidase, leading to its potential efficacy in amelioration of atherosclerosis ( 22 , 23 ).…”

Is Nigella sativa an Effective Bodyweight Lowering Agent and a Mitigator of Obesity Risk? A Literature Review

“… Significant reduction of BW, WC, body fat mass, body fat percent, fat-free mass, and visceral fat area Sensation of appetite decreased significantly as assessed by a visual scale and no difference in dietary intake 2 Mostafa et al 2021. 19 Open label, randomized, study, no negative control Egypt 117 obese prediabetic individuals age (18–65 years), participants with BMI ≥ 30 kg/m 2 and subjects randomly allocated into three groups: Group 1: LM lifestyle (diet and exercise) Group 2: Metformin Group 3: NS -NS soft gelatin capsules containing 450 mg NS- oil twice daily (Total 900mg/day- Baraka ® 450; Pharco Pharmaceutical Company) -Metformin 1000 mg/day. for six months NS- group showed significant reduction of BW and BMI Significant reduction in TC, triglyceride, LDL, FBG, HOMA-insulin resistance, fasting insulin serum and TNF-α level, 3 Hadi et al 2021.…”

“…However, one might argue the clinical significance of NS weight-lowering effect, but we can further illustrate that NS-weight lowering effect is also clinically significant based on the relatively large effect size of 0.6 for NS bodyweight-lowering and 0.4 for waist circumference reduction as reported by Safi et al 18 as well as the frequently and repeatedly demonstrated metabolic effect of NS on lowering blood lipids including triglycerides, total cholesterol, LDL, blood glucose and HbA1C and the positive influence on HDL and insulin resistance. 23,29 In the study performed by Mostafa et al, 19 NS administration for 12 weeks was superior to metformin or diet restriction in modifying total cholesterol, LDL, and triglycerides. Moreover, the clinical significance of NS-weight lowering effect can also be augmented by lifestyle modifications such as caloric restriction and exercise training because evidence has been shown that the combined NS administration and lifestyle changes yielded better effect than each of these interventions separately.…”