Nifedipine, but not propranolol, improves left ventricular systolic and diastolic function in patients with hypertension

Zusman, Randall M.; Christensen, Donna M.; Federman, Elizabeth B.; Ruddy, Terrence D.; Miller, D. Douglas; Boucher, Charles A.

doi:10.1016/0002-9149(89)90747-9

Cited by 31 publications

(15 citation statements)

References 26 publications

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“…Some studies show improved filling (in association with, but possibly independent of, LV mass regression) [100,101]. Two studies, including one in elderly hypertensive patients, failed to demonstrate LV mass regression and improvement in diastolic function [96,102]. Because β-blockade antagonizes catecholamine-mediated LV relaxation, it has been suggested that it can improve diastolic function only if accompanied by blood pressure reduction, relief of ischemia, and prolongation of the time for LV filling [88•].…”

Section: Calcium-channel Blockersmentioning

confidence: 99%

Diastolic function in hypertension

Phillips

Diamond²

2001

Curr Cardiol Rep

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Diastolic dysfunction in patients with hypertension may present as asymptomatic findings on noninvasive testing, or as fulminant pulmonary edema, despite normal left ventricular systolic function. Up to 40% of hypertensive patients presenting with clinical signs of congestive heart failure have normal systolic left ventricular function. In this article we review the pathophysiologic factors affecting diastolic function in individuals with diastolic function, current and emerging tools for measuring diastolic function, and current concepts regarding the treatment of patients with diastolic congestive heart failure.

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Section: Calcium-channel Blockersmentioning

confidence: 99%

Diastolic function in hypertension

Phillips

Diamond²

2001

Curr Cardiol Rep

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“…The effects of different antihypertensive agents on myocardial relaxation vary considerably. For example, despite an equivalent reduction in arterial pressure, nifedipine augments the LV fi lling rate and other relaxation indices, but propranolol does not [37]. Some studies of patients who have hypertensive heart disease indicate that diastolic dysfunction improves as LV hypertrophy regresses [38].…”

Section: Optimal Management Of Hypertensionmentioning

confidence: 99%

Therapeutic approaches to diastolic dysfunction

Janardhanan

Desai²,

Solomon

2009

Current Science Inc

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Progressive abnormalities of passive stiffness or active relaxation of the myocardium that impair ventricular filling during diastole may be an important contributor to the development of heart failure in patients with preserved ejection fraction. In this review, we discuss the epidemiology and pathophysiology of diastolic dysfunction and heart failure with preserved ejection fraction, highlighting potential therapeutic approaches and exploring the limited available evidence base for improving clinical outcomes in patients with these challenging entities.

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“…Nifedipine is also used in the treatment of aortic valve incompetence (7) and pulmonary hypertension (8). These drugs are effective in lowering arterial pressure, relieving myocardial ischemia, and improving both systolic and diastolic left ventricular function (3,4,9). Their beneficial effects have been attributed to peripheral arteriolar dilation, which results in decreases in mean arterial pressure and left ventricular afterload (5,9).…”

Section: Introductionmentioning

confidence: 99%

“…These drugs are effective in lowering arterial pressure, relieving myocardial ischemia, and improving both systolic and diastolic left ventricular function (3,4,9). Their beneficial effects have been attributed to peripheral arteriolar dilation, which results in decreases in mean arterial pressure and left ventricular afterload (5,9). However, there have been few studies on the effects of nifedipine on pulsatile phenomena, either in the systemic or pulmonary circulations.…”

Section: Introductionmentioning

confidence: 99%