Effects of Nifedipine on Systemic and Pulmonary Vascular Impedance in Subjects Undergoing Cardiac Catheterization

Lack of difference between nebivolol/hydrochlorothiazide and metoprolol/hydrochlorothiazide on aortic wave augmentation and central blood pressure

“…This has led to a preference for other betablocking agents including metoprolol and vasodilating beta-blockers such as nebivolol. Like other vasodilating agents, this may offer potential benefit on wave reflection, aortic wave augmentation and central BP by inducing vasorelaxation [12][13][14]. Like other vasodilating agents, this may offer potential benefit on wave reflection, aortic wave augmentation and central BP by inducing vasorelaxation [12][13][14].…”

Antihypertensive role of glossopharyngeal nerve stimulation by nifedipine using as calcium channel blocking agent in hypertension: An experimental study

“…Nifedipine [1,4-dihydropyridine] is a calcium channel blocking agent that reduces the blood pressure (at doses of 20-30 mg) by vascular smooth muscle relaxation and has negative inotropic and chronotropic effects in the heart . It reduces blood pressure by blocking of calcium ion influx into cardiac and vascular cells through voltage-gated calcium channels and by inhibiting voltage dependent L-type calcium channels (Noda et al, 2006;Hasso, 1997). An in vivo rabbit model for investigating sublingual absorption of sublingual drugs may be suitable for studying the urgent effect in the decrease of blood pressure (dali et al, 2006).…”

“…Sublingual use is preferred for nifedipine instead of an oral route for urgent antihypertensive effect through blocking of calcium channels (Noda et al, 2006). In this study, we aimed to investigate whether the rapid antihypertensive effect of nifedipine was associated with stimulations of GPNs and taste buds of tongue innervated by GPNs, in addition to its well-known calcium channel blocking effect.…”

The Pulse of Cardiology

“…Reading their report, skeptics might be tempted to say that the major disadvantage of atenolol is that it reduced heart rate, and that if heart rate remained unchanged, amlodipine would have shown no advantage. But amlodipine and other dihydropyridines do reduce wave reflection, and this is manifest as a reduction in augmentation index and augmentation of the aortic pressure wave, and is seen independently of heart rate when ascending aortic impedance is displayed in the frequency domain (38,39). The studies by Ting et al O'Rourke and Hayward August 18, 2009:714-7 The Pulse of Cardiology showed such behaviors for impedance with nifedipine, nitroprusside, and angiotensin-converting enzyme inhibitors, but not diuretics (41), without a change in heart rate.…”