Nierenbeckentumoren und Phenacetinabusus

“…Chronic abuse of analgesics is now recognised as a cause of renal pelvis and ureteric tumours (Nagel and Hauge, 1963;Nagel et al, 1971 ;Petkovic, 1972Petkovic, , 1975Petkovic, , 1978Bengtsson et al, 1973;Leistenschneider and Ehmann, 1973;Schabert etal., 1973;Leistenschneider et al, 1974;Landmann-Kolbert er al., 1975;Leistenschneider and Nagel, 1977;Gonwa et al, 1980;Mihatsch et al, 1980;Murphy et al, 1980Murphy et al, , 1981Porpaczy and Schramek, 1981;Nocks et al, 1982;Nikolic and Popovic, 1983;Piper et a/., 1985) and Hultengren et al (1965) were the first to draw attention to this relationship. Most reports on analgesic abuse and renal pelvis tumours have come from Sweden, Switzerland, Australia and West Berlin (Hultengren et al, 1965 ;Angervall et al, 1969;Taylor, 1972;Leistenschneider and Ehmann, 1973;Johansson et al, 1974;Landmann-Kolbert et al, 1975;Mihatsch et al, 1980).…”

Section: Discussionmentioning

confidence: 99%

Tumours of the Renal Pelvis and Ureter: Observations in 170 Patients

Steffens

Nagel

1989

Journal of Urology

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A study was made of 170 patients with renal pelvis or ureteric tumours, 160 of whom underwent surgery between 1948 and 198 1. The most important aetiological factor was chronic phenacetin abuse: 2 1.7% of 83 patients with renal pelvis tumours and 11.4% of those with ureteric tumours gave a history of phenacetin abuse. The latency periods ranged from 2 4 to 26 years. This is the first report of a relationship between abuse of analgesics and urothelial tumours from the Federal Republic of Germany.

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“…Phenacetine abuse is defined as the total intake of 1 kg phenacetine or the use of 1 g phenacetine for Correspondence to: W. F. Thon, Urologische Klinik, St~idt. Krankenhaus Siloah, Roesebeckstrasse 15, D-30449 Hannover, Germany, Fax: +49 (511) 927-2241 at least 1 year [35]. The expression analgesic syndrome covers all the side effects that are caused by abuse.…”

Section: Discussionmentioning

confidence: 99%

Denovo urothelial carcinoma of the upper and lower urinary tract in kidney ? transplant patients with end-stage analgesic nephropathy

et al. 1995

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Patients with end-stage analgesic nephropathy bear a higher risk for urothelial cancer than do patients with other renal diseases. In a retrospective study in patients with analgesic nephropathy and kidney transplants we analyzed the prevalence and clinical course of de novo urothelial cancer. Diagnosis of analgesic nephropathy was based on the patients' history and clinical data. Only patients under cyclosporine treatment were included. Between 1968 and 1993, 2,371 kidney transplants were performed on 2,072 patients in the Department of Abdominal and Transplant Surgery. The prevalence of analgesic nephropathy was 3.1%. Of 65 patients with analgesic nephropathy and kidney transplants, 10 (15.4%) developed urothelial carcinoma; 10.8%, bladder cancer; and 9.1%, renal pelvic cancer. The mean age at diagnosis was 56.1 years. Urothelial cancer occurred on average at 33.6 months posttransplantation. On average, 6 of 10 patients with urothelial cancer died of the disease at 16.9 months after the diagnosis. All patients with urothelial bladder cancer had a muscle-infiltrating tumor of moderate or high grade. Since urothelial renal pelvic cancer occurred in 9.1% of our patients with analgesic nephropathy and urological screening is insufficient in patients on dialysis, we suggest that prophylactic nephroureterectomy be performed on one side before transplantation and on the contralateral side at 3-6 months after transplantation. An aggressive approach is indicated in patients with urothelial cancer of the bladder.

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Nierenbeckentumoren und Phenacetinabusus

Cited by 13 publications

References 13 publications

Analgesic Nephropathy and Phenacetin-Induced Transitional Cell Carcinoma - Analysis of 300 Patients with Long-Term Consumption of Phenacetin-Containing Drugs

Analgesic Nephropathy and Phenacetin-Induced Transitional Cell Carcinoma - Analysis of 300 Patients with Long-Term Consumption of Phenacetin-Containing Drugs

Tumours of the Renal Pelvis and Ureter: Observations in 170 Patients

Denovo urothelial carcinoma of the upper and lower urinary tract in kidney ? transplant patients with end-stage analgesic nephropathy

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