1981
DOI: 10.1159/000473263
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Analgesic Nephropathy and Phenacetin-Induced Transitional Cell Carcinoma - Analysis of 300 Patients with Long-Term Consumption of Phenacetin-Containing Drugs

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Cited by 20 publications
(11 citation statements)
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“…Other analgesic-associated diseases are: peptic ulser disease [ 165,179,180,189,191,228,232,267]. Their epidemiologic importance can only be estimated, but it is probably greater than that of kidney disease.…”
Section: Resultsmentioning
confidence: 99%
“…Other analgesic-associated diseases are: peptic ulser disease [ 165,179,180,189,191,228,232,267]. Their epidemiologic importance can only be estimated, but it is probably greater than that of kidney disease.…”
Section: Resultsmentioning
confidence: 99%
“…Chronic abuse of analgesics is now recognised as a cause of renal pelvis and ureteric tumours (Nagel and Hauge, 1963;Nagel et al, 1971 ;Petkovic, 1972Petkovic, , 1975Petkovic, , 1978Bengtsson et al, 1973;Leistenschneider and Ehmann, 1973;Schabert etal., 1973;Leistenschneider et al, 1974;Landmann-Kolbert er al., 1975;Leistenschneider and Nagel, 1977;Gonwa et al, 1980;Mihatsch et al, 1980;Murphy et al, 1980Murphy et al, , 1981Porpaczy and Schramek, 1981;Nocks et al, 1982;Nikolic and Popovic, 1983;Piper et a/., 1985) and Hultengren et al (1965) were the first to draw attention to this relationship. Most reports on analgesic abuse and renal pelvis tumours have come from Sweden, Switzerland, Australia and West Berlin (Hultengren et al, 1965 ;Angervall et al, 1969;Taylor, 1972;Leistenschneider and Ehmann, 1973;Johansson et al, 1974;Landmann-Kolbert et al, 1975;Mihatsch et al, 1980).…”
Section: Discussionmentioning
confidence: 99%
“…Other studies, including autopsy studies, revealed a prevalence of TCC as high as 10% with multifocality in 30% and, often, high-stage and high-grade tumors in patients with analgesic nephropathy. 11,12,14,27 The latent period before a urothelial carcinoma develops is 20 years or more and depends on the cumulative dose of analgesics ingested. 4,10-13, 28 Thon and Kliem and their colleagues 15,16 reviewed 2072 renal transplant patients with respect to analgesic nephropathy and TCC.…”
Section: Discussionmentioning
confidence: 99%
“…Transitionalcell carcinoma has been reported to occur more often in patients who abuse analgesics than in nonabusers. 4,[8][9][10][11][12][13][14][15][16][17][18][19] Because TCC may become even more aggressive under immunosuppression, some transplant centers perform routine bilateral nephroureterectomies before or after renal transplantation in analgesic abusers with ESRD to exclude TCC of the upper urinary tract. 15,16,20,21 Minimally invasive techniques such as laparoscopy have been developed in various medical disciplines with the view of achieving the same result as open surgical procedures with the same safety for the patient and less trauma.…”
Section: Introductionmentioning
confidence: 99%