Nicotinic modulation of auditory attentional shift in the rat

Brown, Dewey C.; Nichols, Justin A.; Thomas, Feba; Dinh, Lu; Atzori, Marco

doi:10.1016/j.bbr.2010.02.046

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…In support of our data, a recent study found that the α7 nAChR partial agonist, RG3487, improved sub-chronic PCP-induced deficits in attentional set-shifting in male Long-Evans rats (Wallace et al, 2011). In addition, nicotine was found to improve auditory and visual shift trials in male Sprague-Dawley rats (Brown et al, 2010). An α7 nAChR full agonist, compound A ((R)-N-(1-azabicyclo[2.2.2]oct-3-yl)(5-(2-pyridyl)thiophene-2-carboxamide), has also been shown to improve olfactory working memory in the odour span task in uncompromised rats (Rushforth et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

et al. 2011

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The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded-Lister rats received sub-chronic PCP (2 mg/kg) or vehicle i.p. twice daily for seven days, followed by 7-days washout. PCP-treated rats then received PNU-120596 (10 mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (P<0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (P<0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors.

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Section: Discussionmentioning

confidence: 99%

PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

et al. 2011

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“…Similarly, in the DMS, lesioning ChIs produces so-called “perseverative” errors, causing difficulty in task-shifting without altering the ability to learn new paradigms (Aoki et al , 2015). Thalamostriatal projections to ChIs help to regulate behavioral switching and attentional set-shifting (Aosaki et al , 1994; Kimura et al , 2004; Brown et al , 2010; Ding et al , 2010; Smith et al , 2011; Bradfield et al , 2013). What is less well understood is how cingulate cortex, which is involved in evaluating the outcomes of actions, complements the PF in shaping ChIs activity to achieve this behavioral endpoint.…”

Section: Chis Regulation Of Behaviormentioning

confidence: 99%

Striatal cholinergic interneurons and Parkinson's disease

Tanimura

Pancani

Lim

et al. 2017

Eur J of Neuroscience

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Giant, aspiny cholinergic interneurons (ChIs) have long been known to be key nodes in the striatal circuitry controlling goal-directed actions and habits. In recent years, new experimental approaches, like optogenetics and monosynaptic rabies virus mapping, have expanded our understanding of how ChIs contribute to the striatal activity underlying action selection and the interplay of dopaminergic and cholinergic signaling. These approaches also have begun to reveal how ChI function is distorted in disease states affecting the basal ganglia, like Parkinson's disease (PD). This review gives a brief overview of our current understanding of the functional role played by ChIs in striatal physiology and how this changes in PD. The translational implications of these discoveries, as well as the gaps that remain to be bridged, are discussed as well.

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“…In contrast, in the rats who learned the task, a momentary pause of behaviors was apparent during auditory cue presentation (see Figure 5A-b and Figure 3). By using this system, it is thus possible to (i) screen rats for "attention deficits" and (ii) study neural mechanisms of attention when combined with neuronal recordings while the animal is attending to the auditory cues [8][9][10] .…”

Section: Representative Resultsmentioning

confidence: 99%

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

Zheng

Ycu

2012

JoVE

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We have developed a fully automated system for operant behavior testing and neuronal activity recording by which multiple cognitive brain functions can be investigated in a single task sequence. The unique feature of this system is a custom-made, acoustically transparent chamber that eliminates many of the issues associated with auditory cue control in most commercially available chambers. The ease with which operant devices can be added or replaced makes this system quite versatile, allowing for the implementation of a variety of auditory, visual, and olfactory behavioral tasks. Automation of the system allows fine temporal (10 ms) control and precise time-stamping of each event in a predesigned behavioral sequence. When combined with a multi-channel electrophysiology recording system, multiple cognitive brain functions, such as motivation, attention, decision-making, patience, and rewards, can be examined sequentially or independently. Video LinkThe video component of this article can be found at https://www.jove.com/video/3685/ Protocol System OverviewThe system comprises three main components: (1) a double-walled sound proof room (Industrial Acoustical Company, Bronx, New York); (2) a multiple channel electrophysiological recording system (Neuralynx, Bozeman, MT); and (3) a fully automated, customized behavioral testing system from the Med Associates Inc. (St. Albans, VT). Figure 1A, the operant chamber is located inside the sound-proof room. A commutator (Model SL-36, Dragonfly Research and Development, Inc., Ridgeley, West Virginia) for connecting cables from headstage to the electrophysiological recording system (Figure1A-a), and a video camera for monitoring and recording animal behaviors are mounted above the operant chamber (Figure1A-b). As shown in Custom-Designed Operant ChamberThe custom-designed, acoustically transparent operant chamber (Figure1A-d) consists of three acoustically transparent walls and one modularoperation panel ( Figure 1B). Three speakers (Cage Tweeter, ENV_224BM, Med Associates) mounted on the top of the middle and two side panels are used for emitting auditory cues. Auditory cues are generated by a calibrated, programmable audio generator (ANL-926). A stimulus light (ENV_221M) and two triple-stimulus LED displays (ENV_222M) are located on the middle and side panels, respectively. These stimulus lights can be used for auditory-visual multi-sensory behavioral tests. A nose poke device with three color LED lights (ENV_114M) is mounted at the bottom of the middle panel. An infrared detector installed within the nose poke unit is used to signal nose poking and holding period. The LED lights within the nose poke unit can be used for training nose-hold inside the hole. A movable response lever (ENV_112CM) is mounted on each side of the operant panel. The mobility of these levers allows flexible control of the presence of the levers, which can be effectively used for both initial task training and the study of several important cognitive functions of the brain (see below). Four ...

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Nicotinic modulation of auditory attentional shift in the rat

Cited by 7 publications

References 34 publications

PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

Striatal cholinergic interneurons and Parkinson's disease

A Fully Automated and Highly Versatile System for Testing Multi-cognitive Functions and Recording Neuronal Activities in Rodents

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