Nicotinic Acid, Thioridazine, Fluoxymesterone and their Combinations in Hospitalized Geriatric Patients: A Systematic Clinical Study

He, Lehmann; Ta, Ban; Bm, Saxena

doi:10.1177/070674377201700408

Cited by 9 publications

(5 citation statements)

References 2 publications

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“…A total of 33 studies were identified in which neuroleptic medications were compared to placebo or to other medications in geriatric samples that comprised some dementia patients 12–44 . In studies intended to compare several medication classes in parallel groups, only neuroleptic and placebo data were used for the metaanalyses.…”

Section: Resultsmentioning

confidence: 99%

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A Metaanalysis of Controlled Trials of Neuroleptic Treatment in Dementia

Schneider

Pollock

Lyness

1990

J American Geriatrics Society

605

300

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Prior qualitative literature reviews about the use of neuroleptics in dementia suggest that they are "modestly effective" in treating agitation and that no single neuroleptic is better than another. To develop a more precise concept of the clinical efficacy of neuroleptics, a metaanalytic review of the existing literature was performed. From double-blind clinical trials that compared a neuroleptic with a placebo in agitated dementia patients, P values and effect-size estimates were obtained, and were assessed by metaanalytic techniques. Results indicated that neuroleptics were significantly more effective than placebo (one-tailed P = .004) and had a small effect size (r = .18). Clinically, neuroleptic treatment changed the improvement rate in agitated dementia patients from .41 to .59 (binomial effect-size display). This indicates that 18 of 100 dementia patients benefited from neuroleptic treatment (beyond that of placebo) and is consistent with the modest efficacy described in previous qualitative reviews. In six studies comparing thioridazine with another neuroleptic, and in five studies comparing haloperidol with another neuroleptic, metaanalysis results did not show that these two medications differed significantly from the comparison medications, which is not inconsistent with the opinion that no single neuroleptic is better than another.

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Section: Resultsmentioning

confidence: 99%

“…Studies Comparing Neuroleptics with Placebo Of the 17 placebo‐controlled studies identified, 12–28 13 used parallel groups and four used cross‐over designs. Eight of the 14 double‐blind studies used random treatment assignment, and one used “preassignment” to treatment (Table 1).…”

Section: Resultsmentioning

confidence: 99%

A Metaanalysis of Controlled Trials of Neuroleptic Treatment in Dementia

Schneider

Pollock

Lyness

1990

J American Geriatrics Society

605

300

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“…Lehmann and Ban (2) found improvement in most symptoms of aged psychotic patients receiving niacin, including the area of excitement. However, in a later study by Lehmann et al (8), who used a methodologically more rigorous research design, niacin produced no significant positive effects on behavior. The dosage range in both studies (300 to 3200 mg per day) was much higher than in the present study.…”

Section: Resultsmentioning

confidence: 91%

Behavioral Effects of Drug Therapy on Psychogeriatric Inpatients. II. Multivitamin Supplement

Altman

Mehta

Evenson

et al. 1973

J American Geriatrics Society

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Psychogeriatric inpatients were treated with a B-complex and C vitamin preparation (Albee with C) for six weeks in a double-blind study. (Total N = 132.) They were rated on the MIBS, a new inpatient behavior form that involves 11 factored scales. One clinically and statistically significant finding emerged: there was a striking decrease in pathologic manifestations on the MIBS Excitement scale for a non-schizophrenic subgroup of the vitamin-treated sample compared to the placebo sample. Implications of this finding are discussed in terms of a detailed examination of the Excitement scale and in terms of a literature review of the effects of vitamin therapy on the behavior of psychogeriatric patients.

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“…The clinical impression was that a favourable therapeutic response to nicotinic acid may be associated with an overall improvement in test performance (including perceptual, cognitive and psychomotor tasks) following carbon dioxide inhalation and with an overall impairment in test performance following intravenous administration of methamphetamine or amobarbital loads (62). Nevertheless in a follow-up study the administration of nicotinic acid in the same dosage range remained entirely ineffective in a group of chronically-hospitalized geriatric patients (63). Since patients were randomly chosen for this latter study, it was speculated that the results in a more homogeneous geriatric population selected on the basis of the former findings might have provided different and possibly more favourable results.…”

Section: In Geriatric Psychiatrymentioning

confidence: 99%

Nicotinic Acid and Psychiatry

Ban

1971

Canadian Psychiatric Association Journal

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Nicotinic Acid, Thioridazine, Fluoxymesterone and their Combinations in Hospitalized Geriatric Patients: A Systematic Clinical Study

Cited by 9 publications

References 2 publications

A Metaanalysis of Controlled Trials of Neuroleptic Treatment in Dementia

A Metaanalysis of Controlled Trials of Neuroleptic Treatment in Dementia

Behavioral Effects of Drug Therapy on Psychogeriatric Inpatients. II. Multivitamin Supplement

Nicotinic Acid and Psychiatry

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