Nicotinic acid esters as coronary vasodilators

Bariana, D. S.; Savić, Marina P.

doi:10.1021/jm00286a027

Cited by 6 publications

(1 citation statement)

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“…Due to the lack of the spectroscopic data for the known compounds 5c , 6a , 6b , 6c , and 7a , we present in this article all the spectroscopic data for them. The structures of synthesized compounds 5a – d , 6a – d , and 7a – d were confirmed on the basis of their spectral data IR, 1 H NMR, 13 C NMR, and electro‐spray ionization high‐resolution mass spectra (ESIHRMS).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Evaluation of Thalidomide and Phthalimide Esters as Antitumor Agents

Zahran

Abdin

Osman

et al. 2014

Archiv der Pharmazie

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A series of thalidomide and phthalimide ester analogs were efficiently synthesized from N-chloromethylthalidomide, N-chloromethylphthalimide, and N-(2-bromoethyl)phthalimide derivatives with various biologically important carboxylic acids. The synthesized compounds were purified and characterized by various chromatographic and spectroscopic techniques. The antitumor activity of all the synthesized compounds was screened against human liver and breast cancer cells, which showed that phthalimide ester 6a was the best cytotoxic compound against MCF7 cells, while all of the tested compounds showed a non-cytotoxic effect against HepG2 cells. Compounds 5a, 6a, and 7a possess immunosuppressant effect, while compounds 5c, 5d, 6c, 6d, 7c, and 7d showed an immunostimmulatory effect. Meanwhile, estimation of the binding affinity for all the synthesized compounds toward the vascular endothelial growth factor receptor (VEGFR) showed that compounds 5a, 5b, and 7d were the most potent inhibitors.

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Section: Resultsmentioning

confidence: 99%