Nicotine transdermal patches using polymeric natural rubber as the matrix controlling system: Effect of polymer and plasticizer blends

“…Natural rubber (NR), used as a biopolymer matrix [16][17][18][19][20], which is a stable colloidal dispersion of cis-1,4-polyisoprene of high molecular mass in an aqueous medium, is obtained from the tree Hevea brasiliensis. Natural rubber is the most attractive and industrially appropriate rubbery material.…”

Section: Introductionmentioning

confidence: 99%

AC and DC electrical conductivity in natural rubber/nanofibrillated cellulose nanocomposites

Ladhar

Arous

Kaddami

et al. 2015

Journal of Molecular Liquids

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“…33 In an absence of an electric field, a surface showed quite irregular pore surface, whereas for the film with electric field a highly dispersed pores occurred throughout the surface. 5 The results of pore formation convincingly suggest that the increase pore formation can be directly related to increase the amount of IN permeation and the diffusion coefficient. Figure 10 shows the diffusion coefficient of IN of the DCNR films and PCz/DCNR films at various electrical potentials (E = 0-9 V or E = 0-2250 V/m).…”

Section: Release Kinetics Of In From In-loaded Dcnr Film and In-dopedmentioning

confidence: 72%

Permeation Study of Indomethacin from Polycarbazole/Natural Rubber Blend Film for Electric Field Controlled Transdermal Delivery

Thorngkham

Paradee

Niamlang

et al. 2015

Journal of Pharmaceutical Sciences

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“…Wang et al [17] prepared uniform chitosan microspheres by film emulsification technique to work as drug delivery system of a protein called BSA. Pichayakorn et al [18] has made a nicotin drug delivery system with NRL films blended with polyvinyl alcohol and tested on pig skin reaching really good rates of liberation aiming the creation of transdermal patches for teraphy. Verma et al…”

Section: Time (Min)mentioning

confidence: 99%

Natural Latex Films as Carrier for Casearia sylvestris Swartz Extract Associated with Ciprofloxacin

Bolognesi¹,

Borges²,

Cinman³

et al. 2015

ACSJ

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In order to create a new sustained drug delivery system applied for tissue regeneration, this study beget a natural rubber latex (NRL) film with Casearia sylvestris extract and ciprofloxacin. Manipulated from the biomaterial latex obtained by the rubber tree Hevea brasiliensis, the NRL film has shown to be a great angiogenic compound and also has shown a great potential in being a possible carrier for sustained drug release. In order to increase the therapeutic spectrum of the film two substances was added to it: the C. sylvestris extract which has antiulcer, anti-inflammatory and Bolognesi et al.; ACSj, 5(1): 17-25, 2015; Article no. ACSj.2015.003 18 wound healing effects due to its casearins and the antibiotic ciprofloxacin which is considered as one of the main drugs used for open wounds in the skin. The study occurred at State São Paulo University in Assis (UNESP-FCL), Brazil. The substances were mixed and a film was made by casting at ambient temperature creating circular films with 5cm of diameter. After that the film was placed in 1 liter of water to start the release study. The release behavior was analyzed by UV-VIS spectrophotometry being the casearins related to the wavelength of 235nm and the ciprofloxacin of 320nm. The film supported the release of compounds, releasing 93.73% of the extract and 56.53% of the drug, along 29 hours. In addition, the incorporation was proven by Scanning Electron Microscopy (SEM), which showed the morphology of pure and incorporated films and also by Fourier Transform Infrared Spectroscopy (FTIR) which has shown that no chemical change occurred during the process. Thereby, according to results, the material has a possible approach to biomedical application. Original Research Article

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Nicotine transdermal patches using polymeric natural rubber as the matrix controlling system: Effect of polymer and plasticizer blends

Cited by 82 publications

References 30 publications

AC and DC electrical conductivity in natural rubber/nanofibrillated cellulose nanocomposites

AC and DC electrical conductivity in natural rubber/nanofibrillated cellulose nanocomposites

Permeation Study of Indomethacin from Polycarbazole/Natural Rubber Blend Film for Electric Field Controlled Transdermal Delivery

Natural Latex Films as Carrier for Casearia sylvestris Swartz Extract Associated with Ciprofloxacin

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