Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis

Mifsud, Jean-Christophe; Hernández, Luis; Hoebel, Bartley G.

doi:10.1016/0006-8993(89)91518-7

Cited by 183 publications

(89 citation statements)

References 13 publications

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“…As nicotine increases DA release by stimulating nicotinic acetylcholine receptors (nAChRs) located in the terminal and somatodendritic regions of the dopaminergic neurons (Marshall et al, 1997;Mifsud et al, 1989;Wonnacott et al, 1990;Nisell et al, 1994a, b), it is possible that GTS inhibits DA release by acting on nAChRs in the dopaminergic neurons. Supporting this idea, it has been reported that ginseng saponins reduced acetylcholine-evoked Na + influx and catecholamine secretion in bovine adrenal chromaffin cells, but did not affect catecholamine secretion induced by high K + (an activator of voltage-sensitive Ca 2 + channels) or veratridine (an activator of voltage-sensitive Na + channels) (Tachikawa et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Effect of Ginseng Saponins on Enhanced Dopaminergic Transmission and Locomotor Hyperactivity Induced by Nicotine

Kim

Shim

Chung

et al. 2005

Neuropsychopharmacol

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Several studies have shown that behavioral hyperactivity induced by psychomotor stimulants is prevented by ginseng saponins. In an attempt to investigate whether the effect of ginseng saponins is through their inhibitory action on the enhanced dopaminergic transmission by psychomotor stimulants, we examined the effects of ginseng total saponin (GTS) presynaptically on nicotine-induced dopamine (DA) release in the striatum of freely moving rats using in vivo microdialysis technique and postsynaptically on the in vitro and in vivo binding of [ 3 H]raclopride to DA D 2 receptors. Also, we examined the effects of GTS on nicotine-induced locomotor hyperactivity and on nicotine-induced Fos protein expression in the nucleus accumbens and striatum. Systemic pretreatment with GTS (100 and 400 mg/kg, intraperitoneally (i.p.)) resulted in a dose-dependent inhibition of locomotor hyperactivity induced by nicotine. GTS decreased nicotine-induced DA release in the striatum in a dose-dependent manner. However, GTS had no effects on resting levels of locomotor activity and extracellular DA in the striatum. GTS inhibited the in vitro binding of [ 3 H]raclopride to rat striatal membranes with an IC 50 of 5.1471.09 mM. High doses of GTS (400 and 800 mg/kg, i.p.) resulted in decreases in the in vivo binding of [ 3 H]raclopride in the striatum. GTS decreased nicotine-induced Fos protein expression in the nucleus accumbens and striatum, reflecting the inhibition by GTS of nicotine-induced enhancement of dopaminergic transmission. The results of the present study suggest that GTS acts not only on dopaminergic neurons directly or indirectly to prevent nicotine-induced DA release but also postsynaptically by binding to DA D 2 receptors. This may explain the blocking effect of GTS on behavioral activation induced by nicotine and conceivably by other psychostimulants. Our data raise the possibility that GTS, by attenuating nicotine-induced enhancement of dopaminergic transmission, may prove to be a useful therapeutic agent for nicotine addiction and warrant further investigation on its effect on nicotine's rewarding property.

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Section: Discussionmentioning

confidence: 99%

Effect of Ginseng Saponins on Enhanced Dopaminergic Transmission and Locomotor Hyperactivity Induced by Nicotine

Kim

Shim

Chung

et al. 2005

Neuropsychopharmacol

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“…Dopamine-Morphine, phencyclidine, amphetamine and nicotine are examples of drugs that can increase extracellular DA, even when infused locally in the NAc [58][59][60][61]. Numerous explanations for addiction to opioid and DA receptor stimulation have been offered.…”

Section: Drug Self-administration and Drug Withdrawalmentioning

confidence: 99%

Accumbens dopamine-acetylcholine balance in approach and avoidance

Hoebel

Avena

Rada

2007

Current Opinion in Pharmacology

151

117

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SummaryUnderstanding systems for approach and avoidance is basic for behavioral neuroscience. Research on the neural organization and functions of the dorsal striatum in movement disorders, such as Huntington's and Parkinson's Disease, can inform the study of the nucleus accumbens (NAc) in motivational disorders, such as addiction and depression. We propose opposing roles for dopamine (DA) and acetylcholine (ACh) in the NAc in the control of GABA output systems for approach and avoidance. Contrary to DA, which fosters approach, ACh release is a correlate or cause of meal satiation, conditioned taste aversion and aversive brain stimulation. ACh may also counteract excessive DA-mediated approach behavior as revealed during withdrawal from drugs of abuse or sugar, when the animal enters an ACh-mediated state of anxiety and behavioral depression. This review summarizes evidence that ACh is important in the inhibition of behavior when extracellular DA is high and the generation of an anxious or depressed state when DA is relatively low.

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“…The effect of nicotine on DA levels may be due in part to activation of nAChRs on DA terminals, as nicotine-elicited DA release can be seen in purified synaptosome preparations from the NAc that are highly enriched in presynaptic elements (Grady et al 1992;Rowell 1995;Wonnacott et al 1990). Although injection of a nicotinic agonist directly into the DA terminal fields of the NAc can stimulate DA release, the strongest effects of nicotine appear to be on the DA cell bodies of the VTA (Mifsud et al 1989). In addition, nicotine infusion into the VTA produces a longer-lasting effect on DA release than infusion into the NAc (Nisell et al 1994).…”

Section: Neuroanatomical and Lesion Studiesmentioning

confidence: 99%

Nicotinic Receptors in the Brain Links between Molecular Biology and Behavior

Picciotto

Caldarone

King

et al. 2000

Neuropsychopharmacology

317

181

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The physiological effects of nicotine are mediated through binding to, and activation of, nicotinic acetylcholine receptors (nAChRs). These nAChRs are pentamers made up of subunits that have distinct, but overlapping expression patterns in subsets of neurons. Molecular cloning and in situ hybridization have been used to identify the expression patterns of different nAChR subunits. Parallel pharmacological studies have characterized the various behavioral actions of nicotine in the whole animal, but it has been difficult to correlate particular subunit compositions of nAChRs with these nicotine-elicited behaviors. This review will attempt to integrate what is known about the molecular, anatomical, and pharmacological properties of nAChR subunits with behavioral data, and summarize current opinions about which nAChR subtypes are responsible for particular behaviors.

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Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis

Cited by 183 publications

References 13 publications

Effect of Ginseng Saponins on Enhanced Dopaminergic Transmission and Locomotor Hyperactivity Induced by Nicotine

Effect of Ginseng Saponins on Enhanced Dopaminergic Transmission and Locomotor Hyperactivity Induced by Nicotine

Accumbens dopamine-acetylcholine balance in approach and avoidance

Nicotinic Receptors in the Brain Links between Molecular Biology and Behavior

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