Accumbens dopamine-acetylcholine balance in approach and avoidance

Hoebel, Bartley G.; Avena, Nicole M.; Rada, Pedro

doi:10.1016/j.coph.2007.10.014

Cited by 151 publications

(124 citation statements)

References 81 publications

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“…Cholinergic interneurons intrinsic in the nucleus accumbens (NAc) are potentially an important target for antidepressant treatments (Chau et al, 2001;Hoebel et al, 2007;Rada et al, 1993Rada et al, , 2006. These neurons are the sole source of local acetylcholine (ACh) in the NAc.…”

Section: Introductionmentioning

confidence: 99%

“…Our previous data suggest that ACh opposes the action of dopamine (DA) in the control of the accumbens g-aminobutyric acid output systems for approach and avoidance behavior (Hoebel et al, 2007). We found that ACh release in the NAc (especially in the posterior medial NAc, ie, the shell) is a correlate or a cause of meal satiation (Avena et al, 2006;Mark et al, 1992), conditioned taste avoidance (Mark et al, 1995), escape from aversive brain stimulation , and anxiety during the state of drug withdrawal (Rada et al, 1991 and sugar withdrawal (Avena et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Fluoxetine Alleviates Behavioral Depression while Decreasing Acetylcholine Release in the Nucleus Accumbens Shell

Chau

Rada

Kim

et al. 2011

Neuropsychopharmacol

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Selective serotonin reuptake inhibitors, such as fluoxetine, have demonstrated the ability to alleviate behavioral depression in the forced swim test; however, the sites and mechanisms of their actions remain to be further elucidated. Previous studies have suggested that behavioral depression in the swim test is mediated in part by acetylcholine (ACh) stimulating the cholinergic M1 receptors in the nucleus accumbens (NAc) shell. The current study tested whether acute, local, and chronic, subcutaneous fluoxetine treatments increase escape motivation during the swim test while simultaneously lowering extracellular ACh in the NAc shell. Experiment 1: Fluoxetine (1.0 mM) infused unilaterally in the NAc shell for 40 min reduced extracellular ACh while simultaneously increasing swimming time. Experiment 2: Fluoxetine (0.2, 0.5, and 0.75 mM) infused bilaterally in the NAc shell on day 3 dose-dependently decreased immobility and increased the total escape attempts (swimming and climbing) compared with Ringer given on day 2. Experiment 3: Fluoxetine (0.5 mM) infused bilaterally in the NAc for 40 min did not affect activities in an open field. Experiment 4: Chronic systemic fluoxetine treatment decreased immobility scores and increased total escape attempt scores compared with control saline treatment. In all, 14 days after the initial swim test, basal extracellular ACh in the shell was still elevated in the saline-treated group, but not in the fluoxetine-treated group. In summary, these data suggest that one of the potential mechanisms by which fluoxetine alleviates behavioral depression in the forced swim test may be to suppress cholinergic activities in the NAc shell.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fluoxetine Alleviates Behavioral Depression while Decreasing Acetylcholine Release in the Nucleus Accumbens Shell

Chau

Rada

Kim

et al. 2011

Neuropsychopharmacol

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“…Dopamine and acetylcholine (ACh) functions are well known in the BIS and BAS related structures. The nucleus accumbens is involved in general incentive motivation for approach behavior depending on ACh and dopamine levels (Hoebel et al 2007). It has been shown previously that simvastatin application alters dopaminergic and cholinergic levels in the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Simvastatin Impairs Spatial Memory in Rats at a Specific Dose Level

Baytan

Alkanat

Okuyan

et al. 2008

Tohoku J. Exp. Med.

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Statins, inhibitors of cholesterol synthesis, are used to prevent cardiovascular complications. Moreover, statins have been shown to influence some cognitive functions. The modulating effects of simvastatin, one member of the statin family, on memory-related neurotransmitters and neuronal structures have also been reported. We aimed to investigate the behavioral effects of long-term simvastatin application on daily activity, psychomotor performance and spatial memory using Sprague-Dawley rats. Simvastatin (10 or 30 mg/kg/day) was administered orally to rats, in parallel with a vehicle-treated group. Daily activity test results of both simvastatin groups were found similar to the vehicle group after five weeks of simvastatin or vehicle application. Psychomotor performance was measured with the rotarod test. After 6 weeks of simvastatin or vehicle application, the vehicle-treated group stayed on the rotarod device for a shorter time compared with both simvastatintreated groups. Spatial memory was evaluated by the Barnes maze test. Four weeks of 10 mg/kg/day simvastatin application led to poorer scores on spatial memory compared to the vehicle group, but surprisingly, this effect was not seen in the 30 mg/kg/day group. Our results revealed that simvastatin administration had no significant effect on daily activity. Psychomotor performance test results suggested that simvastatin alters psychomotor behavior at higher nervous system levels. Spatial memory test results indicate that longterm simvastatin usage impairs spatial memory only at 10 mg/kg/day dose. Barnes maze; behavior; statins; brain; locomotor.Tohoku

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“…Similarly, neural systems responsible for generating approach behavior must be countered by signals that suppress approach behavior under contexts where approach is dangerous or maladaptive (Hoebel et al 2007). The nucleus accumbens (NAc) is acutely involved in food intake and goal-directed, approach behavior.…”

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confidence: 99%

Hedonic and nucleus accumbens neural responses to a natural reward are regulated by aversive conditioning

Roitman¹,

Wheeler²,

Tiesinga³

et al. 2010

Learn. Mem.

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The nucleus accumbens (NAc) plays a role in hedonic reactivity to taste stimuli. Learning can alter the hedonic valence of a given stimulus, and it remains unclear how the NAc encodes this shift. The present study examined whether the population response of NAc neurons to a taste stimulus is plastic using a conditioned taste aversion (CTA) paradigm. Electrophysiological and electromyographic (EMG) responses to intraoral infusions of a sucrose (0.3 M) solution were made in nai ... ve rats (Day 1). Immediately following the session, half of the rats (n ¼ 6; Paired) received an injection of lithium chloride (0.15 M; i.p.) to induce malaise and establish a CTA while the other half (n ¼ 6; Unpaired) received a saline injection. Days later (Day 5), NAc recordings during infusions of sucrose were again made. Electrophysiological and EMG responses to sucrose did not differ between groups on Day 1. For both groups, the majority of sucrose responsive neurons exhibited a decrease in firing rate (77% and 71% for Paired and Unpaired, respectively). Following conditioning, in Paired rats, EMG responses were indicative of aversion. Moreover, the majority of responsive NAc neurons now exhibited an increase in firing rate (69%). Responses in Unpaired rats were unchanged by the experience. Thus, the NAc differentially encodes the hedonic value of the same stimulus based on learned associations.

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Accumbens dopamine-acetylcholine balance in approach and avoidance

Cited by 151 publications

References 81 publications

Fluoxetine Alleviates Behavioral Depression while Decreasing Acetylcholine Release in the Nucleus Accumbens Shell

Fluoxetine Alleviates Behavioral Depression while Decreasing Acetylcholine Release in the Nucleus Accumbens Shell

Simvastatin Impairs Spatial Memory in Rats at a Specific Dose Level

Hedonic and nucleus accumbens neural responses to a natural reward are regulated by aversive conditioning

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