Nicotine-induced nystagmus: Three-dimensional analysis and dependence on head position

Pereira, Cristiana Borges; Strupp, Michael; Eggert, Thomas; Straube, Andreas; Brandt, Thomas

doi:10.1212/wnl.55.10.1563

Cited by 29 publications

(11 citation statements)

References 7 publications

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“…In the following measurements, NIN diminished after 1 mg nicotine, but reversed its direction to a downbeat nystagmus after 2 mg nicotine. Directional changes of NIN were also observed earlier by Pereira et al after cigarette smoking [8]. Several analyses were performed in order to evaluate these correlations.…”

Section: Discussionsupporting

confidence: 62%

The effect of nicotine on perceptual, ocular motor, postural, and vegetative functions at rest and in motion

et al. 2007

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Nicotine has wellknown, unpleasant side effects, e.g., transient dizziness, nausea, and nicotine-induced nystagmus (NIN). To investigate factors influencing these effects, we addressed three questions: (1) Is the intensity of dizziness, nausea, NIN, and unsteadiness dependent on nicotine dosage? (2) Does the intensity of perceptual, ocular motor, vegetative effects, and postural imbalance correlate? (3) Do visual or vestibular motion stimuli produce and/or aggravate distressing dizziness and nausea? Sixty healthy non-smokers or occasional smokers participated; 40 were tested once before and six times after application of a nicotine nasal spray in doses of 1 mg or 2 mg with or without motion stimulation; 20 received a placebo nasal spray. Plasma nicotine concentrations were significantly related to nicotine dosage. Dizziness, nausea, NIN, and unsteadiness also depended on the nicotine dosage (p < 0.01).Nicotine blood concentration was a better predictor for the temporal dependence of nystagmus than nicotine dosage. Dizziness correlated highly with nausea (R = 0.63, p < 0.001). The degree of nicotine-induced nausea significantly correlated with postural imbalance. The time course of postural sway differed according to nicotine dosage and gender: for women, there was no clear relationship between sway magnitude and nicotine dosage, while men showed increased sway with higher dosage. Motion stimulation increased nicotine-induced dizziness and nausea, but did not significantly influence NIN or postural imbalance. Our data support the view that all measured adverse effects reflect dose-dependent nicotine-induced vestibular dysfunction. Additional motion stimulation aggravates dizziness and nausea, i.e., nicotine increases sensitivity to motion sickness.

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Section: Discussionsupporting

confidence: 62%

The effect of nicotine on perceptual, ocular motor, postural, and vegetative functions at rest and in motion

et al. 2007

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“…There, it binds to central and peripheral receptors, crossing the blood-brain barrier (nicotinic cholinergic receptors -nAchR) and, thus, increasing the production of neuromediators such as noradrenalin, acetylcholine, serotonin and dopamine 27 . Even if in a small number, some studies suggest that nicotine can induce an unbalance in the vestibuloocular and vestibulo-spinal reflexes 28,29 . Unfortunately, epidemiological investigations on such associations are very insipient.…”

Section: Discussionmentioning

confidence: 99%

Equilíbrio dinâmico, estilo de vida e estados emocionais em adultos jovens

Cruz¹,

Barreto²,

Fronza³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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A one hypothesis to explain some vestibular peripheral disorders is their association with life style. Thus, studies with young adults are relevant.Aim: to analyze the prevalence of dynamic balance alterations in young adults and their possible association with life style variables, health and negative emotional states (since they can impact the outcome). Materials and Methods:we carried out a non-probabilistic cross-sectional, clinical-retrospective study with young adults (18-32 years of age) from a university with 751 individuals, with a mean age of 22.45± 3.32 years. Life style, health and negative emotional states (NES) variables -depression, stress and anxiety, were collected by means of an interview. The Unterberger test was used in order to check for indications of dynamic balance alterations. Individuals with altered dynamic balance (ADB) were compared to those without these alterations (controls).Results: From our sample, 642 (83.6%) had less than 45º of deviation, while 109 (14.2%) had greater than 45º deviation and were the considered with ADB. The ADB group had a greater prevalence of smoking, alcohol abuse/dependence, high blood pressure and NES.Conclusion: the study highlights the occurrence of ADB which needs to be corroborated in future studies. Braz J Otorhinolaryngol. 2010;76(3):392-8. ORIGINAL ARTICLE BJORL

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“…As previously mentioned, nicotine has been shown to induce nystagmus in some subjects (Pereira et al, 2000;2001). The presence of abnormal nystagmus can lead to poor reading performance in affected individuals, making it difficult for affected persons to keep their place while reading.…”

Section: The Views Expressed In Tffls Article Are Those Of the Authormentioning

confidence: 98%

“…These subsystems consist of eight Nicotine's effects upon oculomotor output, on the other hand, may be most related to concentrations of ACh receptors in the brainstem, particularly in the medial and lateral vestibular nuclei that project to the oculomotor nuclei, to the cerebellum and to the spinal cord. Pereira (2000Pereira ( , 2001 showed that nicotine may mimic an increase in peripheral vestibular input and thus induce the brain to activate vestibular oculomotor responses.…”

Section: The Views Expressed In Tffls Article Are Those Of the Authormentioning

confidence: 99%

“…These compensatory eye movements have been described clinically in other cases of nystagmus as exaggerated fixations-staring-like behaviors that may be directed in the direction of gaze offering the most significant dampening of nystagmus tremor. I predicted that nicotine consumption would lead to an increase in fixation frequency and duration, particularly in "casually smoking subjects" because they have been reported to be more prone to nicotinic nystagmus than their heavy smoking counterparts (Pereira et al, 2000;2001). Again, I expected the casual smokers to generally have a more pronounced oculomotor effect from nicotine than their heavy smoking counterparts due to limited drug tolerance.…”

Section: The Views Expressed In Tffls Article Are Those Of the Authormentioning

confidence: 99%

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Nicotine's Effect Upon the Eye Movements Associated with Reading Comprehension

Barnes¹

2003

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, tjiuM.-]^ Paou^ 41^-^103 Final draft approved: Committee Chairperson DateAfter signature by the chairperson, it is the responsibility of the student to take this form to the Graduate School with the items listed below. GRADUATE SCHOOL USE ONLY _3 Copies of the Dissertation M-Publishing Agreement Form with additional title page and abstract.

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Nicotine-induced nystagmus: Three-dimensional analysis and dependence on head position

Cited by 29 publications

References 7 publications

The effect of nicotine on perceptual, ocular motor, postural, and vegetative functions at rest and in motion

The effect of nicotine on perceptual, ocular motor, postural, and vegetative functions at rest and in motion

Equilíbrio dinâmico, estilo de vida e estados emocionais em adultos jovens

Nicotine's Effect Upon the Eye Movements Associated with Reading Comprehension

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