Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats

Peixoto, Thamara Cherem; Moura, Egberto Gaspar de; Soares, P.N.; Rodrigues, Vanessa Silva Tavares; Claudio-Neto, S.; Oliveira, Elaine de; Manhães, Alex C.; Lisboa, Patrícia Cristina

doi:10.1016/j.appet.2021.105115

Cited by 9 publications

(10 citation statements)

References 70 publications

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“…85 Concerning females, we have recently shown that these animals, despite having normal body mass, show reduced nAChRs as well as leptin resistance in the hypothalamus, suggesting a central inflammatory process, as observed in nicotineexposed males. 86 A limitation of the current study is that we have not assessed α7nAchR in the hypothalamus and adipose tissue.…”

Section: Discussionmentioning

confidence: 95%

Neonatal nicotine exposure changes insulin status in fat depots: sex-related differences

Rodrigues

Miranda

Soares

et al. 2021

J Dev Orig Health Dis

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Nicotine is the main psychoactive substance present in cigarette smoke that is transferred to the baby by breast milk. In rats, maternal nicotine exposure during breastfeeding induces obesogenesis and hormone dysfunctions in adult male offspring. As glucocorticoid (GC), insulin, and vitamin D change both adipogenesis and lipogenesis processes, we assessed parameters related to metabolism and action of these hormones in visceral and subcutaneous adipose tissues (VAT and SAT) of adult male and female rats in a model of neonatal nicotine exposure. At postnatal (PN) day 2, dams were kept with six pups (three per sex) and divided into nicotine and control groups for implantation of osmotic minipumps that released 6 mg/kg nicotine or saline, respectively. At PN180, fat mass, hormone levels, and protein contents of biomarkers of the GC activation and receptor (11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor alpha), insulin signaling pathway [insulin receptor beta (IRβ), phosphorylated insulin receptor substrate 1, insulin receptor substrate 1 (IRS1), phosphorylated serine/threonine kinase (pAKT), serine/threonine kinase, glucose transporter type 4 (GLUT4)], and vitamin D activation and receptor (1α-hydroxylase and vitamin D receptor) were evaluated. While nicotine-exposed males showed increased fat mass, hypercorticosteronemia, hyperinsulinemia, and higher 25-hydroxyvitamin D, these alterations were not observed in nicotine-exposed females. Nicotine-exposed males only showed lower IRS1 in VAT, while the females had hyperglycemia, higher pAKT in VAT, while lower IRβ, IRS1, and GLUT4 in SAT. Parameters related to metabolism and action of GC and vitamin D were unaltered in both sexes. We evidence that exposure exclusively to nicotine during breastfeeding affects the hormone status and fat depots of the adult progeny in a sex-dependent manner.

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Section: Discussionmentioning

confidence: 95%

Neonatal nicotine exposure changes insulin status in fat depots: sex-related differences

Rodrigues

Miranda

Soares

et al. 2021

J Dev Orig Health Dis

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“…Another study found that higher levels of depression in adolescence were associated with more frequent abuse of psychoactive substances in early adulthood; it emphasized that more frequent substance abuse was also associated with an increase in the intensity of depressive symptoms after a few years. 15,16 In addition, nicotine dependence may be associated with anhedonia in patients with depression, and nicotine may have an effect on the hedonic system. 16 Previous studies have shown a positive relationship between trauma and related disorders and smoking.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 In addition, nicotine dependence may be associated with anhedonia in patients with depression, and nicotine may have an effect on the hedonic system. 16 Previous studies have shown a positive relationship between trauma and related disorders and smoking. 17,18 For example, daily cigarette use and nicotine addiction among people with post-traumatic stress disorder (PTSD) were found to be higher than among those without PTSD.…”

Section: Discussionmentioning

confidence: 99%

The relationship between smoking, alcohol, and substance abuse and psychiatric diseases among adolescents treated in a child and adolescent psychiatry inpatient unit

Demir¹,

Dönmez²,

Kartalcı³

et al. 2022

Turk J Pediatr

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Background. This study aimed to investigate the prevalence of smoking, alcohol, and substance abuse disorders among adolescents hospitalized in a university hospital child and adolescent psychiatry inpatient unit with different diagnoses, and to determine the rates of these disorders according to the mental illness diagnosis groups. Methods. The study was conducted with 346 adolescents aged 12-18 who had been hospitalized with any psychiatric diagnosis between September 2016 and January 2020 in the child and adolescent psychiatry inpatient unit. The study considered the psychiatric diagnoses, based on the results of the DSM-5-based psychiatric interview; sociodemographic and clinical characteristics; the psychopathology history of first-degree relatives; comorbidities; length of hospital stay; income levels, and smoking, alcohol, and substance abuse. Results. Twenty-four percent (n=83) of the participants had been smoking for 18 months or longer, 6.9% (n=24) were using alcohol, and 1% (n=28) were substance abusers. When the diagnosis distributions were examined, smoking was found to be higher in those with depressive disorders and trauma and related disorders, while smoking, alcohol, and substance use were found to be higher in the disruptive behavior disorder group. Smoking was found to be significantly lower in the obsessive-compulsive disorder group. Conclusions. Smoking, alcohol, and substance use among inpatient children and adolescents may worsen their existing psychopathology, so health professionals working in this field should consider this situation.

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“…The consumption of nicotine stimulates the production and utilization of DA in the brain [ 119 , 120 , 121 ], which would further encourage nicotine use in individuals with hypodopaminergic signaling. An individual with hypodopaminergic signaling (or RDS) may be more vulnerable to substance use, such as smoking [ 122 , 123 , 124 , 125 , 126 , 127 ], even during pregnancy [ 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 ], leading to potential obesity risks later on in offspring [ 65 , 66 , 91 , 103 , 113 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 ]. If this genetic risk is passed down as well, offspring may also then experience abnormal craving behaviors associated with both obesity and substance abuse.…”

Section: Genetic Factors Of Nicotine Use and Obesity Riskmentioning

confidence: 99%

“…If this genetic risk is passed down as well, offspring may also then experience abnormal craving behaviors associated with both obesity and substance abuse. An animal study observed hyperphagic behavior and preference for a high-sucrose diet in female rats exposed to nicotine during lactation, coinciding with an increase in protein content of DRD2 in the NAc [ 134 ]. There is also evidence that smoking significantly increases DRD2-gene methylation, which contributes to both substance and non-substance addictions [ 79 , 149 ].…”

Section: Genetic Factors Of Nicotine Use and Obesity Riskmentioning

confidence: 99%

Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review

White

Roeder

Blum

et al. 2022

IJERPH

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Nicotine usage by mothers throughout pregnancy has been observed to relate to numerous deleterious effects in children, especially relating to obesity. Children who have prenatally been exposed to nicotine tend to have lower birth weights, with an elevated risk of becoming overweight throughout development and into their adolescent and adult life. There are numerous theories as to how this occurs: catch-up growth theory, thrifty phenotype theory, neurotransmitter or endocrine imbalances theory, and a more recent examination on the genetic factors relating to obesity risk. In addition to the negative effect on bodyweight and BMI, individuals with obesity may also suffer from numerous comorbidities involving metabolic disease. These may include type 1 and 2 diabetes, high cholesterol levels, and liver disease. Predisposition for obesity with nicotine usage may also be associated with genetic risk alleles for obesity, such as the DRD2 A1 variant. This is important for prenatally nicotine-exposed individuals as an opportunity to provide early prevention and intervention of obesity-related risks.

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Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats

Cited by 9 publications

References 70 publications

Neonatal nicotine exposure changes insulin status in fat depots: sex-related differences

Neonatal nicotine exposure changes insulin status in fat depots: sex-related differences

The relationship between smoking, alcohol, and substance abuse and psychiatric diseases among adolescents treated in a child and adolescent psychiatry inpatient unit

Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review

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