Nicotine Decreases Food Intake Through Activation of POMC Neurons

Mineur, Yann S.; Abizaid, Alfonso; Rao, Yan; Salas, Ramiro; DiLeone, Ralph J.; Gündisch, Daniela; Diano, Sabrina; Biasi, Mariella De; Horváth, Tamas L.; Gao, Xiao‐Bing; Picciotto, Marina R.

doi:10.1126/science.1201889

Cited by 344 publications

(336 citation statements)

References 33 publications

Supporting

Mentioning

298

Contrasting

Unclassified

Order By: Relevance

“…Beyond nicotine anorectic action, nAChRs are well known to be involved in the regulation of food intake. In the lateral hypothalamus, neuronal networks express α4β2 and α7nAChRs [27][28][29] whereas α3β4 nAChRs seem rather implicated in both stimulation of POMC neurons [30] and inactivation of hypothalamic AMPK [31]. Surprisingly, the slight hyperphagia of α7β2nAChR −/− mice did not change their body weight but was associated with a modification of their body composition, with increased lean and bone mass and decreased fat pads, which can explain their increased sensitivity to fasting-induced weight loss.…”

Section: Discussionmentioning

confidence: 97%

Concomitant alpha7 and beta2 nicotinic AChR subunit deficiency leads to impaired energy homeostasis and increased physical activity in mice

Somm

Guérardel

Maouche

et al. 2014

Molecular Genetics and Metabolism

View full text Add to dashboard Cite

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated cation channels well characterized in neuronal signal transmission. Moreover, recent studies have revealed nAChR expression in nonneuronal cell types throughout the body, including tissues involved in metabolism. In the present study, we screen gene expression of nAChR subunits in pancreatic islets and adipose tissues. Mice pancreatic islets present predominant expression of α7 and β2 nAChR subunits but at a lower level than in central structures. Characterization of glucose and energy homeostasis in α7β2nAChR −/− mice revealed no major defect in insulin secretion and sensitivity but decreased glycemia apparently unrelated to gluconeogenesis or glycogenolysis. α7β2nAChR −/− mice presented an increase in lean and bone body mass and a decrease in fat storage with normal body weight. These observations were associated with elevated spontaneous physical activity in α7β2nAChR −/− mice, mainly due to elevation in fine vertical (rearing) activity while their horizontal (ambulatory) activity remained unchanged. In contrast to α7nAChR −/− mice presenting glucose intolerance and insulin resistance associated to excessive inflammation of adipose tissue, the present metabolic phenotyping of α7β2nAChR −/− mice revealed a metabolic improvement possibly linked to the increase in spontaneous physical activity related to central β2nAChR deficiency.

show abstract

Section: Discussionmentioning

confidence: 97%

Concomitant alpha7 and beta2 nicotinic AChR subunit deficiency leads to impaired energy homeostasis and increased physical activity in mice

Somm

Guérardel

Maouche

et al. 2014

Molecular Genetics and Metabolism

View full text Add to dashboard Cite

show abstract

“…Studies suggest that nicotine promotes increased energy expenditure and reduces appetite, which explains why smokers having a lower BMI than nonsmokers, and the common weight gain after smoking cessation 12,31,32 . In contrast, it is observed that heavy smokers (> 40 cigarettes/day) tend to have higher body weight than light smokers (< 20 cigarettes/day).…”

Section: Discussionmentioning

confidence: 99%

Hormonal, metabolic and nutritional alterations in smokers: emergency for smoking abstinence

Rodrigues

Melquíades

Leite³

et al. 2013

J. bras. psiquiatr.

View full text Add to dashboard Cite

Objective: To evaluate the biochemical and nutritional status of smokers in treatment for smoking cessation and its association with anthropometric parameters. Methods: This is a cross-sectional study with convenience sample. Adult smokers were assessed at the start of treatment in the Interdisciplinary Center for Tobacco Research and Intervention of the University Hospital of the Federal University of Juiz de Fora (CIPIT/HU-UFJF). We evaluated the body mass index (BMI), conicity index (CI); waist circumference (WC), percentage of body fat (%BF), fasting glycemia, cortisol, insulin, total cholesterol (TC), LDL-c, HDL-c, triglycerides (TG) and metabolic syndrome (MS). Original article Rodrigues GRS et al. colesterol LDL-c, HDL-c, triglicéridos (TG) e síndrome metabólica (SM). resultados: A maioria dos participantes possuía SM e alto risco cardiovascular. A glicemia de jejum estava alterada em 30,4%. Houve correlação positiva significativa entre IMC e CC (r = 0,90; p = 0,0001), %GC (r = 0,79; p = 0,0001), IC (r = 0,65; p = 0,0001), glicemia (r = 0,42; p = 0,04) e TG (r = 0,47; p = 0,002). O IC também apresentou correlação positiva com insulina (r = 0,6; p = 0,001), glicemia (r = 0,55; p = 0,007), TG (r = 0,54; p = 0,008) e %GC (r = 0,43; p = 0,004). Pacientes com maior tempo de tabagismo tiveram maior risco de desenvolver SM (O = 9,6; p = 0,016). conclusão: Os fumantes avaliados tiveram maior risco de desenvolver SM, especialmente aqueles que fumavam por mais tempo, requerendo urgência para a cessação tabágica.cortisol 12,13 . In addition, chronic smokers are at increased risk for developing insulin resistance and inadequate compensatory response of insulin secretion, which promotes the association of smoking with an increased risk of type 2 diabetes mellitus 14 .Evaluation of endocrine-metabolic changes that promote tobacco use, can aid understanding of factors involved in the changes of body weight and the development of chronic diseases associated with smoking. This article aims to evaluate the biochemical and nutritional status of smokers at the start of treatment for smoking cessation and its association with anthropometric indices.

show abstract

“…NPY dan orexin dapat meningkatkan nafsu makan. 27 Nikotin ikut terhirup pada saat seseorang merokok atau terpapar asap rokok.…”

Section: Pembahasanunclassified

EKSTRAK DAUN Nicotiana tabacum MENURUNKAN BERAT LEMAK VISCERAL PADA TIKUS DIABETES MELLITUS TIPE DUA

Suprapto

Jonathan²,

Ernanda³

et al. 2017

View full text Add to dashboard Cite

AbstrakDiabetes mellitus merupakan masalah utama kesehatan di dunia dan prevalensinya selalu meningkat. Pada dosis yang tepat kandungan nikotin dari ekstrak etanol daun tembakau (Nicotiana tabacum) memiliki efek hipoglikemik sehingga berpeluang sebagai terapi alternatif untuk diabetes mellitus. Namun, efeknya pada jaringan adipose penderita diabetes mellitus belum banyak diketahui. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh ekstrak etanol daun tembakau terhadap berat lemak visceral tikus model diabetes mellitus. Pada penelitian ini tikus galur Wistar dibagi menjadi 5 kelompok yaitu kontrol negatif (K-), kelompok tikus model diabetes mellitus (K+), dan tiga kelompok tikus diabetes melitus yang diberi ekstrak etanol daun tembakau 90 (P1), 180 (P2) dan 270 (P3) mg/kgBB/hari per oral selama 28 hari. Hasil penelitian menunjukkan bahwa terdapat penurunan bermakna berat lemak pada semua kelompok tikus DM yang diberi ekstrak daun tembakau dibandingkan dengan tikus DM tanpa terapi maupun tikus normal (p < 0,05). Kesimpulan penelitian adalah pemberian ekstrak etanol daun tembakau menurunkan berat lemak visceral pada tikus model DM. Penurunan berat lemak visceral kemungkinan disebabkan oleh kandungan nikotin dalam ekstrak yang dapat mengaktivasi lipolisis, menghambat lipogenesis, aktivasi thermogenesis, dan penurunan intake makan.Kata kunci: berat lemak visceral, diabetes mellitus, daun tembakau (Nicotiana tabacum). ETHANOL EXTRACT OF Nicotiana tabacum REDUCES THE VISCERAL WEIGHT OF TYPE TWO DIABETIC RATS AbstractDiabetes melllitusis the main health problem in the world and its prevalence is increasing dramatically. Tobacco leaf (Nicotiana tabacum) containing nicotine could be used as an alternative treatment for diabetes mellitus at the right dose. However, its effect on adipose tissue of diabetes mellitus model has not established well. This study aim is to observe the effect of ethanol extract of tobacco leaf to the visceral weight of diabetic rats. Rats were divided into five group normal rats (K-), diabetic rats (K+) and diabetic rats receiving ethanol extract of tobacco leaf at dose 90 (P1), 80 (P2), and 270 (P3) mg/kgBW/day orally for 28 days. Rats were sacrificed and visceral fat was weighed afterward. As the result, visceral fat of diabetic rats was less than the normal rats and diabetic rats treated with ethanol extract of tobacco leaf shown to reduce visceral weight significantly compared to normal rats (p < 0.05). Visceral weight decrement was due to nicotine effect that could induce lipolysis, inhibit lipogenesis, thermogenesis activation, and reduce food intake. Further research is needed to explore Nicotiana tabacum as an alternative treatment for diabetes mellitus.

show abstract

Nicotine Decreases Food Intake Through Activation of POMC Neurons

Cited by 344 publications

References 33 publications

Concomitant alpha7 and beta2 nicotinic AChR subunit deficiency leads to impaired energy homeostasis and increased physical activity in mice

Concomitant alpha7 and beta2 nicotinic AChR subunit deficiency leads to impaired energy homeostasis and increased physical activity in mice

Hormonal, metabolic and nutritional alterations in smokers: emergency for smoking abstinence

EKSTRAK DAUN Nicotiana tabacum MENURUNKAN BERAT LEMAK VISCERAL PADA TIKUS DIABETES MELLITUS TIPE DUA

Contact Info

Product

Resources

About