Nicotine augmentation for refractory obsessive-compulsive disorder. A case report

Pasquini, Massimo; Garavini, Alessandra; Biondi, Massimo

doi:10.1016/j.pnpbp.2004.08.011

Cited by 27 publications

(25 citation statements)

References 17 publications

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“…It has been suggested that nicotinic activation of an already hyperactivated fronto-striatal circuit worsens OCD symptoms (Abramovitch et al, 2015). However, other studies have shown that nicotine augmentation improves clinical symptoms in patients with OCD (Carlsson, 2001; Pasquini et al, 2005). Glutamatergic hyperactivity associated with OCD may also be due to mediation of glutamate release by nicotinic receptor activation.…”

Section: Discussionmentioning

confidence: 96%

Attenuation of Compulsive-Like Behavior Through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Non-Induced Compulsive-Like Mice

Mitra

Mucha

Khatri

et al. 2017

Front. Behav. Neurosci.

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Nicotinic α4β2 receptors are the most abundant subtypes of nicotinic acetylcholine receptors (nAChRs) expressed in brain regions implicated in obsessive compulsive disorder (OCD). These receptors are known to modify normal and addictive behaviors by modulating neuronal excitability. Desformylflustrabromine (dFBr) is a novel, positive allosteric modulator (PAM) of high acetylcholine sensitivity (HS) and low acetylcholine sensitivity (LS) α4β2 nAChRs. The present study tested the hypothesis that positive allosteric modulation of α4β2 receptors by dFBr will attenuate compulsive-like behavior in a non-induced compulsive-like mouse model. Male mice (Mus musculus) selected for compulsive-like nesting behavior (NB; 48 animals; 12 per group) received acute (once) and chronic (every day for 32 days) subcutaneous injection of dFBr at 2, 4 and 6 mg/kg doses. Saline was used as a control (0 mg/kg). Compulsive-like NB was assessed after 1, 2, 3, 4, 5 and 24 h, while compulsive-like marble burying (MB) and anxiety-like open field (OF) behaviors were performed 2 h after dFBr administration. In the acute administration protocol, dFBr dose dependently attenuated NB and MB. Rapid effects (1–2 h after drug administration) of dFBr on MB and NB were observed for the chronic administration which was in congruence with the acute study. Chronic administration also revealed sustained suppression of NB by dFBr following 5 weeks of treatment. In both the acute and chronic regimen dFBr did not modulate OF behaviors. This research demonstrates the novel role of positive allosteric modulation of α4β2 nicotinic receptors by dFBr as a translational potential for OCD.

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Section: Discussionmentioning

confidence: 96%

Attenuation of Compulsive-Like Behavior Through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Non-Induced Compulsive-Like Mice

Mitra

Mucha

Khatri

et al. 2017

Front. Behav. Neurosci.

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“…A transdermal nicotine patch, administered as therapy for TS, decreases the severity and frequency of tics, a compulsory symptom of TS (Sanberg, 1997). Nicotine gum administered to OCD patients previously resistant to other treatment clinically improved behavior (Carlsson, 2001;Pasquini et al, 2005). Interestingly, clomipramine, an SSRI commonly prescribed for the treatment of OCD, also acts on nAChRs (Lopez-Valdes, 2002).…”

Section: Nachrs Modulate Multiple Behaviors Deficient In Asdmentioning

confidence: 99%

Nicotinic Acetylcholine Receptor Alterations in Autism Spectrum Disorders – Biomarkers and Therapeutic Targets

Anand¹,

Amici²,

Ponath³

et al. 2011

Autism - A Neurodevelopmental Journey From Genes to Behaviour

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“…15 Nicotine (in the form of chewing gum or a transdermal patch) is also being explored as an experimental treatment for Obsessive-Compulsive Disorder (OCD). 16,17 Even with these potential benefits of nicotine, concerns still exist that it may induce behavioural deficits especially in non-pathologic states. 18 …”

Section: Introductionmentioning

confidence: 99%

Performance of motor associated behavioural tests following chronic nicotine administration

Ijomone¹,

Olaibi²,

Biose³

et al. 2014

ANS

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BackgroundNicotine has shown potential therapeutic value for neurodegenerative diseases though there are concerns that it may induce behavioural deficits.PurposeThe present study sought to determine the effect of chronic nicotine administration on overall motor functions and coordination.MethodsForty adult female and male Wistar rats were randomly grouped into 4 groups. Treated groups were administered nicotine via subcutaneous injections at doses of 0.25, 2 and 4 mg/kg body weight for 28 days. Control groups received normal saline. All animals were monitored for the first few minutes after each injection for any observed immediate effect of drug administration. Motor associated behavioural tests performed include: open field test, string test for grip strength and limb impairment, movement initiation and step test.ResultsNicotine induced muscular convulsions within the first 1-5 minutes following daily subcutaneous injections, throughout the period of administration. This was observed to be more severe in females. Nicotine did not produce major alterations in overall motor functions and coordination in both females and males.ConclusionThe present study shows chronic nicotine treatment produces muscular convulsion but no major deficit in overall motor function and coordination and that any observed alterations may just be transient effects.

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Nicotine augmentation for refractory obsessive-compulsive disorder. A case report

Cited by 27 publications

References 17 publications

Attenuation of Compulsive-Like Behavior Through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Non-Induced Compulsive-Like Mice

Attenuation of Compulsive-Like Behavior Through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Non-Induced Compulsive-Like Mice

Nicotinic Acetylcholine Receptor Alterations in Autism Spectrum Disorders – Biomarkers and Therapeutic Targets

Performance of motor associated behavioural tests following chronic nicotine administration

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