Nicotine and extinction of fear conditioning

Elias, Gabriel A.; Gulick, Danielle; Wilkinson, Derek S.; Gould, Thomas J.

doi:10.1016/j.neuroscience.2009.11.022

Cited by 32 publications

(44 citation statements)

References 46 publications

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“…Therefore, according to some accounts, PTSD may be attributed to impaired safety learning (Davis, Falls, & Gewirtz, 2000; Lissek et al, 2005). The effects of nicotine exposure on safety learning and extinction have been investigated using the animal models of fear extinction and contextual safety discrimination (Elias, Gulick, Wilkinson, & Gould, 2010; Kutlu & Gould, 2014; Kutlu, Oliver, & Gould, 2014; Tian et al, 2008). For example, Elias et al (2010) found that acute nicotine enhanced extinction and impaired renewal of cued fear memories when administered during the extinction phase, whereas nicotine administration during both training and extinction phases impaired extinction and enhanced renewal of cued fear.…”

Section: Involvement Of Nachrs In Anxiety and Anxiety Disordersmentioning

confidence: 99%

“…The effects of nicotine exposure on safety learning and extinction have been investigated using the animal models of fear extinction and contextual safety discrimination (Elias, Gulick, Wilkinson, & Gould, 2010; Kutlu & Gould, 2014; Kutlu, Oliver, & Gould, 2014; Tian et al, 2008). For example, Elias et al (2010) found that acute nicotine enhanced extinction and impaired renewal of cued fear memories when administered during the extinction phase, whereas nicotine administration during both training and extinction phases impaired extinction and enhanced renewal of cued fear. This suggests that acute nicotine may enhance recovery and extinction of cued fear conditioning by potentially strengthening encoding and facilitating new inhibitory learning during acquisition and extinction, respectively.…”

Section: Involvement Of Nachrs In Anxiety and Anxiety Disordersmentioning

confidence: 99%

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Nicotine Addiction and Psychiatric Disorders

Kutlu

Parikh

Gould

2015

International Review of Neurobiology

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Even though smoking rates have long been on the decline, nicotine addiction still affects 20% of the US population today. Moreover, nicotine dependence shows high comorbidity with many mental illnesses including, but are not limited to, attention deficit hyperactivity disorder, anxiety disorders, and depression. The reason for the high rates of smoking in patients with mental illnesses may relate to attempts to self-medicate with nicotine. While nicotine may alleviate the symptoms of mental disorders, nicotine abstinence has been shown to worsen the symptoms of these disorders. In this chapter, we review the studies from animal and human research examining the bidirectional relationship between nicotine and attention deficit hyperactivity disorder, anxiety disorders, and depression as well as studies examining the roles of specific subunits of nicotinic acetylcholine receptors (nAChRs) in the interaction between nicotine and these mental illnesses. The results of these studies suggest that activation, desensitization, and upregulation of nAChRs modulate the effects of nicotine on mental illnesses.

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Section: Involvement Of Nachrs In Anxiety and Anxiety Disordersmentioning

confidence: 99%

Section: Involvement Of Nachrs In Anxiety and Anxiety Disordersmentioning

confidence: 99%

Nicotine Addiction and Psychiatric Disorders

Kutlu

Parikh

Gould

2015

International Review of Neurobiology

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“…However, it should be noted that higher doses of nicotine are anxiogenic and can act as stressors (Yu & Sharp, 2010). Interestingly, nicotine can also enhance cued extinction after delay fear conditioning (Elias, Gulick, Wilkinson, & Gould, 2010), a task that relies on cortical substrates similar to those that support the acquisition of trace fear conditioning (Stafford, Raybuck, Ryabinin, & Lattal, 2012). …”

Section: Nicotine and Fear Conditioningmentioning

confidence: 99%

Substance abuse, memory, and post-traumatic stress disorder

Tipps

Raybuck

Lattal

2014

Neurobiology of Learning and Memory

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A large body of literature demonstrates the effects of abused substances on memory. These effects differ depending on the drug, the pattern of delivery (acute or chronic), and the drug state at the time of learning or assessment. Substance use disorders involving these drugs are often comorbid with anxiety disorders, such as post-traumatic stress disorder (PTSD). When the cognitive effects of these drugs are considered in the context of the treatment of these disorders, it becomes clear that these drugs may play a deleterious role in the development, maintenance, and treatment of PTSD. In this review, we examine the literature evaluating the cognitive effects of three commonly abused drugs: nicotine, cocaine, and alcohol. These three drugs operate through both common and distinct neurobiological mechanisms and alter learning and memory in multiple ways. We consider how the cognitive and affective effects of these drugs interact with the acquisition, consolidation, and extinction of learned fear, and we discuss the potential impediments that substance abuse creates for the treatment of PTSD.

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“…Previous work does suggest that nicotine can function as a cognitive enhancer, augmenting learning, memory, and attention (Couey et al, 2007; Levin et al, 2006; Mansvelder et al, 2006; Newhouse et al, 2004) with effects demonstrated in extinction (Elias et al, 2010; Kaplan et al, 2011). As extinction is new learning (Bouton and King, 1983, Rescorla, 2004), the nicotine treatment may be enhancing this learning.…”

Section: Discussionmentioning

confidence: 99%

“…As extinction is new learning (Bouton and King, 1983, Rescorla, 2004), the nicotine treatment may be enhancing this learning. This explanation does have a major issue; the enhancement of learning associated with nicotine is found when nicotine is administered concurrently with the learning (Elias et al, 2010; Gould and Higgins, 2003; Gould and Wehner, 1999; Tian et al, 2008). In the present report, nicotine was administered during the self-administration phase and halted prior to the extinction phase.…”

Section: Discussionmentioning

confidence: 99%

Nicotine- and cocaine-triggered methamphetamine reinstatement in female and male Sprague-Dawley rats

Pittenger

Chou

Barrett

et al. 2017

Pharmacology Biochemistry and Behavior

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Preclinical studies have demonstrated a return to methamphetamine (meth)-seeking behavior (reinstatement) induced by injections of meth administered by the experimenter (drug-prime). Notably, females tend to be more sensitive to drug-prime; often displaying more reinstatement behavior when compared to males. While meth-primed reinstatement of meth-seeking behavior has been established, little is known about the ability of other drugs of abuse to substitute for meth during drug-primed reinstatement; nicotine and cocaine were the focus of the present work. We also examined if self-administration and/or reinstated meth-seeking behavior was affected by repeated nicotine administration. Male and female Sprague-Dawley rats were trained to self-administer meth during daily sessions. During this self-administration phase, rats were placed into 1 of 2 groups: saline or repeated nicotine exposure. Rats in the repeated nicotine group received nicotine injections 4h after meth self-administration sessions, whereas the remaining rats received saline. Following self-administration was extinction in which meth was no longer available and nicotine was no longer administered. After extinction, rats were tested to determine if 0 (saline), 0.2, and 0.4 mg/kg nicotine reinstated meth-seeking behavior. Three days of re-extinction followed nicotine testing. Finally, rats received reinstatement tests with 0 (saline), 5, and 10 mg/kg cocaine. Nicotine and cocaine reinstated meth-seeking behavior in male and female rats with no difference between the sexes. Repeated nicotine administration potentiated meth reinstatement following the 0.4 mg/kg nicotine-prime. While females may be more sensitive to reinstatement triggered with the original self-administration drug, this effect may not generalize to priming with other drugs of abuse.

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Nicotine and extinction of fear conditioning

Cited by 32 publications

References 46 publications

Nicotine Addiction and Psychiatric Disorders

Nicotine Addiction and Psychiatric Disorders

Substance abuse, memory, and post-traumatic stress disorder

Nicotine- and cocaine-triggered methamphetamine reinstatement in female and male Sprague-Dawley rats

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