Nicotine- and cocaine-triggered methamphetamine reinstatement in female and male Sprague-Dawley rats

Pittenger, Steven T.; Chou, Shinnyi; Barrett, Scott T.; Catalano, Isabella; Lydiatt, Maxwell; Bevins, Rick A.

doi:10.1016/j.pbb.2017.07.003

Cited by 5 publications

(7 citation statements)

References 58 publications

(96 reference statements)

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“…The first group was experimental receiving METH (0.4 mg/kg), subcutaneously in 0.6 mL volume for 3 weeks as described before. 12 The second group was sham receiving normal saline (0.6 mL, subcutaneously) for 21 days and the third one was the control group receiving distilled water, identically for 3 weeks. Daily experiments were done in the morning from 08:00 to 12:00 AM.…”

Section: Introductionmentioning

confidence: 99%

“… 11 Females were shown to be more sensitive to METH with more reinstatement behaviour. 12 METH was demonstrated to cause a potentially lethal increase in core body temperature, or hyperthermia, 13 while METH-induced hyperthermia has a prominent role in the thermogenic brown adipose tissue that can lead to weight loss. 14 In animals, the physiological effects of METH use were studied revealing a rise in heart rate, arterial pressure, body temperature and locomotor activity.…”

Section: Introductionmentioning

confidence: 99%

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Histological Changes in Adipose Tissue: An Alarm When Methamphetamine Is Targeted for Weight Loss Purposes

Jaafari-Sheybani

Hoseini

Mehrabani

et al. 2021

wjps

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BACKGROUND Methamphetamine (METH) may be administered for weight loss purposes and to understand the METH side-effects more in details, this study aimed at determining the effect of METH on changes in adipose tissue in experimental rats. METHODS Forty five male Wistar rats were randomly allocated to three equal groups. Group 1 was experimental receiving METH [0.4 mg/kg, subcutaneously (S/C), 0.6 mL/rat] for 3 weeks, group 2 was the sham group receiving normal saline (0.6 mL/rat, S/C) and the 3 rd group was the control receiving distilled water, identically. The elevated plus maze test was used to confirm cognitive impairment and distraction as anxiety and to verify addiction to METH by assessing the percent time spent in open arm (OAT), the percent time spent in closed arm (CAT), the percent time spent in central parts and head dipping over the side of the maze. Adipose tissue was assessed histologically 7, 14 and 21-days after interventions. RESULTS A significant increase in anxiety level, and histologically inflammation, degeneration and necrosis in adipose tissue were visible after METH use. CONCLUSION METH use resulted in a significant inflammation and necrosis in adipose tissue denoting to the dangers of METH use, when recreationally targeted for weight loss purposes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histological Changes in Adipose Tissue: An Alarm When Methamphetamine Is Targeted for Weight Loss Purposes

Jaafari-Sheybani

Hoseini

Mehrabani

et al. 2021

wjps

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“…Previous studies have examined sex differences in animal models of methamphetamine addiction and have focused on differences during selfadministration, extinction and drug-or cue-induced reinstatement of methamphetamine seeking (Roth & Carroll, 2004;Holtz et al, 2012;Reichel et al, 2012;Ruda-Kucerova et al, 2015;Bernheim et al, 2017;Cox et al, 2017;Pittenger et al, 2017;Weber et al, 2018). The current study examined whether sex differences occur during context-driven reinstatement of extinguished methamphetamine-seeking behavior following prolonged abstinence from methamphetamine self-administration.…”

Section: Discussionmentioning

confidence: 98%

Sex Differences in Context-Driven Reinstatement of Methamphetamine Seeking Is Associated with Distinct Neuroadaptations in the Dentate Gyrus<strong> </strong>

Takashima

Tseng

Fannon

et al. 2018

Preprint

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The present study examined differences in operant responses in adult male and female rats during distinct phases of addiction. Males and females demonstrated escalation in methamphetamine (0.05 mg/kg, i.v.) intake with females showing enhanced latency to escalate, and bingeing. Following protracted abstinence, females show reduced responses during extinction, and have greater latency to extinguish compared with males, indicating reduced craving. Females demonstrated lower context-driven reinstatement compared to males, indicating that females have less motivational significance to the context associated with methamphetamine. Whole-cell patch-clamp recordings on dentate gyrus (DG) granule cell neurons (GCNs) were performed in acute brain slices from controls and methamphetamine experienced male and female rats and neuronal excitability were evaluated from GCNs. Reinstatement of methamphetamine seeking reduced spiking in males, and increased spiking in females compared to controls, demonstrating distinct neuroadaptations in intrinsic excitability of GCNs in males and females. Reduced excitability of GCNs in males were associated with enhanced levels of neural progenitor cells, expression of plasticity-related proteins including CaMKII and choline acetyltransferase in the DG. Enhanced excitability in females were associated with increased GluN2A/2B ratio, indicating changes in postsynaptic GluN subunit composition in the DG.  Altered intrinsic excitability of GCNs were associated with reduced mossy fiber terminals in the hilus and pyramidal projections, demonstrating compromised neuroplasticity in the DG in both sexes. The alterations in excitability, plasticity-related proteins and mossy fiber density were correlated with enhanced activation of microglial cells in the hilus, indicating neuroimmune responses in both sexes. Together, the present results indicate sexually dimorphic adaptive biochemical changes in excitatory neurotransmitter systems in the DG and highlight the importance of including sex as a biological variable in exploring neuroplasticity and neuroimmune changes that predict enhanced relapse to methamphetamine-seeking behaviors.

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“…Interestingly, 5-mg/kg cocaine (ip) may induce significant physiological effects in rats with prior cocaine exposure (leading to cocaine sensitization). In fact, 5-mg/kg cocaine (ip) has usually been used (by many researchers and our own lab as well) as a priming dose to induce reinstatement after cocaine self-administration in rat models, 12,13 suggesting that 5-mg/kg cocaine (ip) may induce significant physiological effects in rats with prior cocaine exposure. This is because, prior to the cocaine reinstatement testing, the cocaine exposure has already induced DAT trafficking to the plasma membrane such that the rats have become more sensitive to cocaine.…”

Section: Discussionmentioning

confidence: 99%

Cocaine hydrolase blocks cocaine‐induced dopamine transporter trafficking to the plasma membrane

et al. 2021

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Cocaine blocks dopamine uptake via dopamine transporter (DAT) on plasma membrane of neuron cells and, as a result, produces the high and induces DAT trafficking to plasma membrane which contributes to the drug seeking or craving. In this study, we first examined the dose dependence of cocaine-induced DAT trafficking and hyperactivity in rats, demonstrating that cocaine at an intraperitoneal dose of 10 mg/kg or higher led to redistribution of most DAT to the plasma membrane while inducing significant hyperactivity in rats. However, administration of 5-mg/kg cocaine (ip) did not significantly induce DAT trafficking or hyperactivity in rats. So the threshold (intraperitoneal) dose of cocaine that can significantly induce DAT trafficking or hyperactivity should be between 5 and 10 mg/kg. These data suggest that when a cocaine dose is high enough to induce significant hyperactivity, it can also significantly induce DAT trafficking to the plasma membrane. Further, the threshold brain cocaine concentration required to induce significant hyperactivity and DAT trafficking was estimated to be $2.0 ± 0.8 μg/g. Particularly, for treatment of cocaine abuse, previous studies demonstrated that an exogenous cocainemetabolizing enzyme, for example, CocH3-Fc(M3), can effectively block cocaineinduced hyperactivity. However, it was unknown whether an enzyme could also effectively block cocaine-induced DAT trafficking to the plasma membrane. This study demonstrates, for the first time, that the enzyme is also capable of effectively blocking cocaine from reaching the brain even with a lethal dose of 60-mg/kg cocaine (ip) and, thus, powerfully preventing cocaine-induced physiological effects such as the hyperactivity and DAT trafficking.

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Nicotine- and cocaine-triggered methamphetamine reinstatement in female and male Sprague-Dawley rats

Cited by 5 publications

References 58 publications

Histological Changes in Adipose Tissue: An Alarm When Methamphetamine Is Targeted for Weight Loss Purposes

Histological Changes in Adipose Tissue: An Alarm When Methamphetamine Is Targeted for Weight Loss Purposes

Sex Differences in Context-Driven Reinstatement of Methamphetamine Seeking Is Associated with Distinct Neuroadaptations in the Dentate Gyrus<strong> </strong>

Cocaine hydrolase blocks cocaine‐induced dopamine transporter trafficking to the plasma membrane

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