Nicotine alters the usual reciprocity between meal size and meal number in female rat

Miyata, Go; Meguid, Michael M.; Varma, Madhu; Fetissov, Sergueı̈ O.; Kim, Hyune Ju

doi:10.1016/s0031-9384(01)00540-6

Cited by 70 publications

(72 citation statements)

References 32 publications

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“…However, asymptomatic immunosuppression such as mild hypogammaglobulinemia, which was seen in smokers like the current case (15,16), has not yet been identified as a risk. A low body weight and gastrointestinal disorders are common in smokers (17)(18)(19), as was also observed in the current case. Dietary problems are a major contributing factor, including anorexia, dyspeptic symptoms and diarrhea.…”

Section: Discussionsupporting

confidence: 87%

Severe Pneumonia Caused by a Novel Influenza A (H1N1) Virus in an Asymptomatic Emphysematous Smoker

et al. 2010

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A 49-year-old female presented with diarrhea and a high fever followed by progressive dyspnea. Until this presentation, she had been healthy except for chronic dyspepsia and diarrhea. She had a smoking habit of 15 pack-years. Laboratory tests revealed lymphopenia, hypoalbuminemia and hypogammaglobulinemia. A rapid influenza test in combination with an RT-PCR assay revealed the presence of the novel influenza A (H1N1) virus. Chest computed tomography revealed centrilobular emphysema. This report suggests that regular smoking may become a risk for severe pneumonia in patients presenting with the novel influenza A (H1N1) virus, when accompanying asymptomatic emphysema is combined with other problems such as hypoalbuminemia and hypogammaglobulinemia.

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Section: Discussionsupporting

confidence: 87%

Severe Pneumonia Caused by a Novel Influenza A (H1N1) Virus in an Asymptomatic Emphysematous Smoker

et al. 2010

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“…Second, the findings are in accordance with the evidence that a high amount of nicotine consumed is related to low food intake, change of the metabolic rate or decreased body weight set point. 4,[18][19][20][21]35 With an increasing number of of cpd in former smokers, there may be an increasing urge to compensate missing stimulation. The clear linear relationship between the number of cpd and the proportion of overweight and more so of obesity supports such an assumption.…”

Section: Smoking and Overweight U John Et Almentioning

confidence: 99%

“…18 According to an animal study nicotine may lengthen intermeal time and simultaneously decrease the size of the meals taken. 19 Hypothalamic nuclei and neurotransmitters, particularly dopamine and serotonin, have been considered in appetite regulation; however, neurobiological evidence about smoking cessation and eating is fragmentary. 20,21 Evidence suggests that the risk of weight gain is highest during the first year after quitting and declines over the years.…”

Section: Introductionmentioning

confidence: 99%

Smoking status, cigarettes per day, and their relationship to overweight and obesity among former and current smokers in a national adult general population sample

et al. 2005

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BACKGROUND: Weight gain after smoking cessation is perceived to be a barrier against quitting smoking. The goal was to analyze overweight and obesity depending on smoking status and number of cigarettes per day (cpd) among former and current smokers. METHODS: The sample included 7124 residents of Germany aged 18-79 y from a national health examination survey (participation rate: 61.4%). Body weight and height were objectively measured; smoking status and cpd were assessed by a questionnaire administered in a health examination center. RESULTS: The number of cpd was positively related to being overweight and more so to obesity among former smoking men, but not women. The results were adjusted for age, school education, exercise and alcohol consumption. Men who formerly had smoked more than 30 cpd had an adjusted odds ratio (OR) of 5.0 for obesity compared to men who had never smoked. CONCLUSION: With an increasing number of cpd more psychological and physiological processes of compensation of nicotine supply after smoking cessation may be expected. Male smokers should be provided with information on how to prevent weight gain after smoking cessation. To foster smoking cessation, female smokers should be informed that women who stop smoking manage to have no increase in the rates of overweight or obesity when considered at the general population level.

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“…Studies of feeding behavior reveal that smoking or nicotine administration decreases meal size, measured as the amount of food intake per meal, without substantial changes in meal number (Blaha et al, 1998;Miyata et al, 2001). Although studies of nicotineinduced changes in overall metabolic rate are more variable (Stamford et al, 1986;Sztalryd et al, 1996), nicotine administration has been shown to alter metabolic processing in humans, intact animals and in both hepatocytes and adipocytes, in vitro (Sztalryd et al, 1996;Ashakumary and Vijayammal, 1997;Arai et al, 2001).…”

Section: Does Nicotine Affect Feeding Via Interactions At Peripheral mentioning

confidence: 99%

Nicotinic receptor‐mediated effects on appetite and food intake

Jo¹,

Talmage

Role³

2002

J. Neurobiol.

276

197

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ABSTRACT:It is well known, although not well understood, that smoking and eating just do not go together. Smoking is associated with decreased food intake and lower body weight. Nicotine, administered either by smoking or by smokeless routes, is considered the major appetite-suppressing component of tobacco. Perhaps the most renowned example of nicotine's influence on appetite and feeding behavior is the significant weight gain associated with smoking cessation. This article presents an overview of the literature at, or near, the interface of nicotinic receptors and appetite regulation. We first consider some of the possible sites of nicotine's action along the complex network of neural and non-neural regulators of feeding. We then present the hypothesis that the lateral hypothalamus is a particularly important locus of the anorectic effects of nicotine. Finally, we discuss the potential role of endogenous cholinergic systems in motivational feeding, focusing on cholinergic pathways in the lateral hypothalamus.

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Nicotine alters the usual reciprocity between meal size and meal number in female rat

Cited by 70 publications

References 32 publications

Severe Pneumonia Caused by a Novel Influenza A (H1N1) Virus in an Asymptomatic Emphysematous Smoker

Severe Pneumonia Caused by a Novel Influenza A (H1N1) Virus in an Asymptomatic Emphysematous Smoker

Smoking status, cigarettes per day, and their relationship to overweight and obesity among former and current smokers in a national adult general population sample

Nicotinic receptor‐mediated effects on appetite and food intake

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