Nicotinamide riboside ameliorates high-fructose-induced lipid metabolism disorder in mice <i>via</i> improving FGF21 resistance in the liver and white adipose tissue

Zhao, Hui; Tian, Yingjie; Zuo, Yuwei; Zhang, Xiaoqi; Gao, Yijun; Wang, Peng; Sun, Lirui; Zhang, Huaqi; Liang, Hui

doi:10.1039/d2fo01934e

Cited by 13 publications

(7 citation statements)

References 59 publications

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“…Existing studies have demonstrated that the NF-κB pathway can regulate lipid metabolism and then affect DSS-induced colitis [34], atherosclerosis [35] and NAFLD [36]. The latest research has disclosed that nicotinamide riboside ameliorate high-fructose-induced lipid metabolism disorder may be related to the regulation of inflammation mediated by the SIRT1/NF-κB signaling pathway [37]. AMPK is also identified as a key molecule in the regulation of biological energy metabolism and lipid metabolic-related diseases [38].…”

Section: Discussionmentioning

confidence: 99%

Global Trends of Lipid Metabolism Research in Epigenetics Field: A Bibliometric Analysis from 2012–2021

Liu

Huang

et al. 2023

IJERPH

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Most common diseases are characterized by metabolic changes, among which lipid metabolism is a hotspot. Numerous studies have demonstrated a strong correlation between epigenetics and lipid metabolism. This study of publications on the epigenetics of lipid metabolism searched in the Web of Science Core Collection from 2012 to 2022, and a total of 3685 publications were retrieved. Much of our work focused on collecting the data of annual outputs, high-yielding countries and authors, vital journals, keywords and citations for qualitative and quantitative analysis. In the past decade, the overall number of publications has shown an upward trend. China (1382, 26.69%), the United States (1049, 20.26%) and Italy (206, 3.98%) were the main contributors of outputs. The Chinese Academy of Sciences and Yale University were significant potential cooperation institutions. Articles were mainly published in the “International Journal of Molecular Sciences”. In addition to typical liver-related diseases, “ferroptosis”, “diabetes” and “atherosclerosis” were identified as potential research topics. “NF-κB” and “oxidative stress” were referred to frequently in publications. METTL3 and ALKBH5 were the most discussed m6A-related enzymes in 2022. Our study revealed research hotspots and new trends in the epigenetics of lipid metabolism, hoping to provide significant information and inspiration for researchers to further explore new directions.

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Section: Discussionmentioning

confidence: 99%

Global Trends of Lipid Metabolism Research in Epigenetics Field: A Bibliometric Analysis from 2012–2021

Liu

Huang

et al. 2023

IJERPH

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“…Western blotting was carried out as described in previous studies, , with slight modifications. Briefly, the liver tissues from different groups were homogenized on ice and centrifuged at low temperature, followed by collecting the supernatant and determining the protein concentrations by BCA assay (Meilunbio Biotechnology, China).…”

Section: Methodsmentioning

confidence: 99%

Astaxanthin Protects against Alcoholic Liver Injury via Regulating Mitochondrial Redox Balance and Calcium Homeostasis

Wang,

Zheng,

et al. 2023

J. Agric. Food Chem.

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“…Western blotting followed our previous procedures [ 26 , 27 , 28 ]. For nuclear extraction, placental whole lysates were suspended in a hypotonic buffer and stored on ice for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Dietary Folic Acid Supplementation Attenuates Maternal High-Fat Diet-Induced Fetal Intrauterine Growth Retarded via Ameliorating Placental Inflammation and Oxidative Stress in Rats

Zhang

Wang

et al. 2023

Nutrients

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The placenta is particularly susceptible to inflammation and oxidative stress, leading to placental vascular dysfunction and placental insufficiency, which is associated with fetal intrauterine growth restriction (IUGR). It is unknown whether folic acid (FA) supplementation can alleviate high-fat diet-induced IUGR in rats by improving placental function. In this study, pregnant rats were randomized into one of four diet-based groups: (1) control diet (CON), (2) control diet supplemented with FA, (3) high-fat diet (HFD), and (4) high-fat diet supplemented with FA (HFD + FA). Dams were sacrificed at gestation day 18.5 (GD18.5). The results indicated that dietary FA supplementation normalized a maternal HFD-induced decrease in fetal weight. The decrease in placental efficiency, labyrinth zone (LZ) area, blood sinusoid area, vascular density, and the levels of angiogenesis factors induced by a maternal HFD were alleviated by the addition of FA, suggesting that FA supplementation can alleviate placental vascular dysplasia. Furthermore, FA supplementation increased the protein expressions of SIRT1, inhibited NF-κB transcriptional activation, attenuated the levels of NF-κB/downstream pro-inflammatory cytokines, induced Nrf2 activation, and increased downstream target protein expression. In conclusion, we found that dietary FA supplementation during pregnancy could improve maternal HFD-induced IUGR by alleviating placental inflammation and oxidative stress, which may be associated with the regulation of SIRT1 and its mediated NF-κB and Nrf2 signaling pathways.

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Nicotinamide riboside ameliorates high-fructose-induced lipid metabolism disorder in mice via improving FGF21 resistance in the liver and white adipose tissue

Abstract: NR supplementation could ameliorate high-fructose-induced lipid metabolism disorder by improving FGF21 resistance in the liver and WAT, which may be related to the inflammation state mediated by SIRT1/NF-κB signaling pathway.

Cited by 13 publications

References 59 publications

Global Trends of Lipid Metabolism Research in Epigenetics Field: A Bibliometric Analysis from 2012–2021

Global Trends of Lipid Metabolism Research in Epigenetics Field: A Bibliometric Analysis from 2012–2021

Astaxanthin Protects against Alcoholic Liver Injury via Regulating Mitochondrial Redox Balance and Calcium Homeostasis

Dietary Folic Acid Supplementation Attenuates Maternal High-Fat Diet-Induced Fetal Intrauterine Growth Retarded via Ameliorating Placental Inflammation and Oxidative Stress in Rats

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