Nickel (II), Copper (II), and Zinc (II) Complexes of N-bis (4-methoxybenzyl) Dithiocarbamate: Synthesis, Characterization Studies, and Evaluation of Antitumor Activity

Antiproliferative activity of Fe(ii), Co(ii), Ni(ii), Cu(ii), and Zn(ii) complexes of dithiocarbamate: synthesis, structural characterization, and thermal studies

“…11,12 Recently, many transition metal dithiocarbamate complexes containing cyclohexyl and methoxybenzyl groups in their ligand systems have been reported as potential anti-cancerous agents against lung, colon, liver, breast, and many other cancer cells. [13][14][15][16][17][18][19] In recent years, there has been extensive exploration of the coordination chemistry of dithiocarbamates due to their ability to bind with a variety of metals, including transition, main group, actinide, and lanthanide metals, typically in a bidentate manner. [20][21][22][23] Dithiocarbamate (dtc) ligands have the capacity to form stable metal complexes, and these complexes exhibit diverse structural characteristics in the solid state.…”

“…[24][25][26][27] Among the class of sulfur-containing ligands, N,Ndisubstituted dithiocarbamates offer numerous possibilities for designing and synthesizing dithiocarbamate compounds. 15 Motivated by these observations, we herein report the synthesis and characterization of a new N-cyclohexyl N- (3,4dimethoxybenzyl) dithiocarbamate ligand and its five new [M (ligand) 2 ] type metal complexes (1)(2)(3)(4)(5) where M = Fe(II), Co(II), Ni(II), Cu(II), and Zn(II) respectively. The crystal structures of complexes 4 and 5 and their magnetic and spectroscopic properties as well as thermal decomposition behaviour are also described.…”

“…11,12 Recently, many transition metal dithiocarbamate complexes containing cyclohexyl and methoxybenzyl groups in their ligand systems have been reported as potential anti-cancerous agents against lung, colon, liver, breast, and many other cancer cells. 13–19…”

“…24–27 Among the class of sulfur-containing ligands, N , N -disubstituted dithiocarbamates offer numerous possibilities for designing and synthesizing dithiocarbamate compounds. 15…”

Spectroscopic and electrochemical investigation of ternary Cu (II) complex interaction with calf thymus DNA

“…The highest cytotoxic activity was measured using Cu (II) complex. 37 Singh et al 38 have fabricated Ni (II), Cu (II), and Zn (II) complexes of N-bis (4-methoxybenzyl) dithiocarbamate. These complexes exhibited extraordinary antitumor activities against Dalton's lymphoma cells.…”