Antiproliferative activity of Fe(ii), Co(ii), Ni(ii), Cu(ii), and Zn(ii) complexes of dithiocarbamate: synthesis, structural characterization, and thermal studies

Abstract

Five new metal complexes of Fe(ii) (1), Co(ii) (2), Ni(ii) (3), Cu(ii) (4), and Zn(ii) (5), derived from an N-cyclohexyl N-(3,4-dimethoxybenzyl) dithiocarbamate ligand as anticancer drug. Complex 5 showed more potential antiproliferative activity.

Design, synthesis, and structural evaluation of metal complexes of azepane-1-carbodithioate for targeting human breast cancer: investigating cytotoxic activity against the MDA-MB-231 cell line

“…These bond lengths agree well with those of the complexes reported earlier. 37,38 The C(1)–S(1) and C(1)–S(2) bond distances are 1.7285(14) and 1.7256(14) Å, respectively, comparable to previously reported complexes and indicating that the carbon–sulfur bond is intermediate between a single and a double bond length. 37 Weak intramolecular C–H⋯S hydrogen bonding interactions among the dithio sulfur atom and the C–H hydrogens of the azepane ring help stabilize the structure of complex 2 (Fig.…”

“…All Cu–S bond lengths are uneven being 2.2893(4), 2.3134(4), 1.7285(14), and 1.7256(14) Å (Table S2, ESI†) and are analogous to the bond distances which closely resemble those found in previously reported Cu( ii ) complexes. 37 The bite angles (S(1)–Cu–S(2) = 77.59(13)°) for the two metal chelate rings are smaller than the standard bond angle of 90°, indicating a distorted square planar geometry around the Cu( ii ) ion. The nitrogen–carbon bond lengths present in the –NCS 2 moieties [N(1)–C(1) = 1.3224(18) Å, N(1)–C(2) = 1.4791(19) Å, and N(1)–C(7) = 1.4685(19) Å] are smaller than the standard N–C single bond length ascribed to the partial double bond character and recommend the π-electron delocalization in the NCS 2 moiety.…”

Exploring the BSA- and DNA-binding, cytotoxicity, and cell cycle evaluation of ternary copper(ii)/diimine complexes with N,N-dibenzyl-N′-benzoylthiourea as promising metallodrug candidates

“…35 The presence of various weak intermolecular hydrogen bonding interactions stabilizing the crystal self-assembly have been observed in several biologically actives copper complexes recently reported. 36,37…”