Nickel (II), copper (II), and vanadyl (II) complexes with tridentate nicotinoyl hydrazone derivative functionalized as effective catalysts for epoxidation processes and as biological reagents

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Mononucleating complexes of isatin hydrazone sodium sulfonate ligand (HLn) with palladium (II) and cobalt (II) ions: The complexes were synthesized within 1:1 and 2:1 molar ratio of HLn with Pd 2+ and Co 2+ ion in PdLn and Co (Ln) 2 , respectively. The catalytic reactivity of both complexes was examined in the oxidation of sulfides (diphenyl sulfide, dps, and methylphenyl sulfide, mps) using hydrogen peroxide under aerobic conditions. Oxoproducts, dipheylsufoxide, dpo, and methyl phenyl sulfoxide, mpo, are the chemoselective products with detection of large amounts of the unselective further oxidation products of dioxoproducts (dipheylsufone, dpn, and methylphenyl sulfone, mpn). The homogenous catalyst of Co (Ln) 2 revealed more efficient action compared to that of PdLn depending on the high electrochemical reversible potential of the central metal ion in the catalytic reaction within the electron and/or oxygen transfer system. Exploring the importance of the M 2+ ion in the coordinated ligand, the bioreactivity of HLn, PdLn, and Co (Ln) 2 was illustrated within some commonly well-known bacteria and fungi strains. Additionally, they were involved as anticancer reagents against some human cancer cell lines in vitro. Both metal complexes presented high inhibited action versus the growth of the studied microorganism and cancer. The interaction effect of Pd 2+ and Co 2+ ions in their pincer complexes was tested with calf thymus DNA spectroscopically and via the viscosity changes.

Section: Antibacterial Studiesmentioning

confidence: 99%

Section: Anticancer Studiesmentioning

confidence: 99%

Section: Anticancer Assaymentioning

confidence: 99%

Section: Hydrodynamic Assaymentioning

confidence: 99%

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Promoted catalytic potential in sulfides oxidation and biological screening of green Pd (II) and Co (II) complexes of salicylidene isatin hydrazone ligand

Adam

Makhlouf

Mohamed

et al. 2022

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“…As documented, in protic solvents, Schiff base complexes were known to be decomposed, such as water, and with strong coordinating solvents they can easily react, such as DMF and DMSO, to yield different coordination species. [48] Therefore, the stability experiments were performed in water, DMSO and AN spectroscopically before applying further scientific research. The results signify no observable decomposition for the free ligand and its complexes over 4 days at room temperature.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Two ionic oxo‐vanadate and dioxo‐molybdate complexes of dinitro‐aroylhydrazone derivative: Effective catalysts for epoxidation reactions, biological activity, ctDNA binding, density functional theory, andin silicoinvestigations

Adam

Shaaban

El‐Metwaly

2022

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To meet the ecological demand for synthesis of ecofriendly metalated organic compounds, two new green dinitro‐aroylhydrazone derivatives (HLZNa) were used for the synthesis of vanadate(IV) and cis‐molybdate(VI) complexes (VOLZNa and MoO2LZNa). The N,O‐bidentate ligand and its M‐pincer chelates were characterized using various spectroscopic tools. Infrared spectra exhibited a high shift of the CH=N band with the disappearance of the O–H band of HLZNa after its coordination with V4+ and Mo6+ in VOLZNa and MoO2LZNa, respectively. 1H NMR spectra supported this observation for HLZNa compared with that of MoO2LZNa for the spectral signal of CH=N and O–H groups. In the UV–Vis. spectra, VOLZNa showed an additional spectral band at 741 nm for the d → d transition, which accomplished such complexation. Catalytically, VOLZNa exhibited slightly more catalytic action, with 92% yield after 2 h, compared with the MoO2LZNa catalyst (4 h with 92% yield) in the oxygenation of 1,2‐cyclooctene, that is, the epoxidation, at 90 °C. A strong reversible electrochemical behavior of VOLZNa (V4+/V5+redox couple) enhanced the catalytic action of VOLZNa over MoO2LZNa, which is supported by spectroscopic analysis. The biological behavior of HLZNa, VOLZNa, and MoO2LZNa was examined through their binding ability to ctDNA via UV–Vis. spectroscopy and hydrodynamic measurements. Spectroscopically, the derived binding constant of VOLZNa and MoO2LZNa (Kb = 4.45 and 5.01 × 108 mol−1 dm3, respectively) was higher than that of the free ligand (HLZNa, 2.88 × 108 mol−1 dm3), which is attributed to their reactivity toward ctDNA. Also, the Gibbs free energy values ( ∆Gb≠) for such an interaction illustrated their high potential against ctDNA over their ligand (−31.14, −32.22, and −32.52 kJ/mol for HLZNa, VOLZNa, and MoO2LZNa, respectively). The metal ions (V4+ and Mo6+) in VOLZNa and MoO2LZNa, respectively, improved their antioxidant, antimicrobial, and antitumor activities over the free ligand. The structures of the current compounds were further elucidated using the DFT/B3LYP method, which confirmed the mode of bonding depending on the distribution of the coordinating functional groups. Some physical parameters were estimated to evaluate the probability of these compounds' reactivity biologically and catalytically. The catalytic role of the MoO2LZNa complex was confirmed computationally. The in vitro obtains regarding the antimicrobial activity of the M‐chelates were tested using in silico approaches. The outcomes reflected the high conformity of VOLZNa as an effective antimicrobial reagent.

Complexation behavior of copper and zinc divalent ions towards diisatin malonyl dihydrazone ligand with biological and catalytic assessments

Adam,

Alghanim,

Abualreish

et al. 2024

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According to the interesting reactivity of arylhydrazones in coordination chemistry and biological assays, malonyl dihydrazone ligand of diisatin derivative (H2Lm) was reacted with Cu2+ and Zn2+ ions forming two complexes of dinuclear homoleptic mode (CuLm and ZnLm, respectively). Demonstration of their chemical structures was confirmed through various spectroscopic ways alongside the elemental analyses (EA), conductivity measurements, and magnetic characteristics.Their bio‐performance was recorded based on their inhibited potential of the growing ability of some common bacteria, fungi, and human cancer/normal cell lines. The biological studies appointed the role and job of M2+ ion = Cu2+ or Zn2+ in its chelated MLm complex to perform the bio‐reactivity over the free ligand, H2Lm. Moreover, their interacted modes with ctDNA (i.e., calf thymus DNA) were examined via the viscometry and spectrophotometric titration. Because the two chelates (CuLm and ZnLm) represented an attractive job for the inhibited action against the current microorganisms and the human cancer/normal strains' growth over the free H2Lm ligand, CuLm and ZnLm complexes displayed a distinguished interaction with ctDNA more than that of their uncoordinated H2Lm ligand. From the values of binding constant (Kb) and Gibb's free energy ( ), CuLm assigned more bio‐action within ctDNA more than ZnLm H2Lm ligand, referring to the role of Cu2+ ion with more electronegativity to enhance the reactivity of CuLm over their free H2Lm ligand and ZnLm.The catalytic behavior of CuLm and ZnLm was given within the epoxidation of 1,2‐cyclohexene (an example of unsaturated hydrocarbons) homogeneously using hydrogen peroxide (the oxidant). Their catalytic action was optimized through various temperatures, solvents, time, and type of M2+ ion in the catalyst.