Promoted catalytic potential in sulfides oxidation and biological screening of green Pd (II) and Co (II) complexes of salicylidene isatin hydrazone ligand

Abstract

Mononucleating complexes of isatin hydrazone sodium sulfonate ligand (HLn) with palladium (II) and cobalt (II) ions: The complexes were synthesized within 1:1 and 2:1 molar ratio of HLn with Pd 2+ and Co 2+ ion in PdLn and Co (Ln) 2 , respectively. The catalytic reactivity of both complexes was examined in the oxidation of sulfides (diphenyl sulfide, dps, and methylphenyl sulfide, mps) using hydrogen peroxide under aerobic conditions. Oxoproducts, dipheylsufoxide, dpo, and methyl phenyl sulfoxide, mpo, are the chemoselective products with detection of large amounts of the unselective further oxidation products of dioxoproducts (dipheylsufone, dpn, and methylphenyl sulfone, mpn). The homogenous catalyst of Co (Ln) 2 revealed more efficient action compared to that of PdLn depending on the high electrochemical reversible potential of the central metal ion in the catalytic reaction within the electron and/or oxygen transfer system. Exploring the importance of the M 2+ ion in the coordinated ligand, the bioreactivity of HLn, PdLn, and Co (Ln) 2 was illustrated within some commonly well-known bacteria and fungi strains. Additionally, they were involved as anticancer reagents against some human cancer cell lines in vitro. Both metal complexes presented high inhibited action versus the growth of the studied microorganism and cancer. The interaction effect of Pd 2+ and Co 2+ ions in their pincer complexes was tested with calf thymus DNA spectroscopically and via the viscosity changes.

Melatonin Derivative-Conjugated Formulations of Pd(II) and Pt(II) Thiazoline Complexes on Mesoporous Silica to Enhance Cytotoxicity and Apoptosis against HeLa Cells

“…215 nm changes its intensity ratio with respect to the main peak as the incubation time increases, changing the morphology of the graph with respect to the free DNA. This behavior has previously been observed for other Pd(II) complexes, where a red shift occurs due to π → π*/n → π* transition bands, as the complex is incubated with more DNA [ 49 ]. This may indicate that the palladium complex functionalized in silica also interacts with DNA, which is one of the therapeutic targets, but whose mechanism of action is different from that of the platinum compound.…”

“…Figure 3 A shows how functionalization with a metal complex (PtTdTn or PdTdTn) produces an intense absorption band between ca. 250 and 400 nm for the ligand–metal charge transfer absorptions and for the d–d transitions, corresponding to the molecular d-orbital of the metal complexes [ 49 ]. The same behavior is found in the 5MT functionalized materials as shown in Figure 3 B, where an additional absorption band around 228 nm, associated with the incorporation of the 5MT directing agent, is observed although it is obscured by the large absorption from the metal complexes.…”

Biophysical study on DNA and BSA binding activity of Cu(II) complex: Synthesis, molecular docking, cytotoxic activity, and theoretical approach

“…The viscosity measurement method was used to confirm the DNA binding activity and mode of binding of the compounds with CT‐DNA with changing the concentration of HL and CuL 2 . Ethidium bromide (EB), as a classical positive standard intercalator, was used to measure interaction with DNA 59 . Any perturbation in DNA helical structure may influence the DNA viscosity effectively.…”

“…Ethidium bromide (EB), as a classical positive standard intercalator, was used to measure interaction with DNA. 59 Any perturbation in DNA helical structure may influence the DNA viscosity effectively. The relative viscosity of the DNA solution increases, due to elongation of DNA double helix when the compound is inserted within the bases of DNA, 60 which leads the intercalation binding mode.…”