Nickel Ferrite (NiFe₂O₄) Nanoparticles as Magnetically Recyclable Nanocatalyst for Highly Efficient Synthesis of 4H-Chromene Derivatives

Abstract

An adapted one-pot route to nanocatalyst-assisted synthesis of 4H-chromenes via three component condensation reaction between dimedone, malononitrile, and a broad range of aryl aldehydes by the use of magnetic nickel ferrite nanoparticles is described. By this achievement, not only a novel route to highly efficient synthesis of these series of heterocycles was introduced but also the scope of these medicinally important products was developed via preparation of some novel products. Above all, a new application of nickel ferrite nanoparticles (NiFe2O4 NPs) as highly efficient, green and magnetically recyclable catalyst has been introduced. Overall, obtaining good to excellent yields of products, environmentally and economic benign procedure, easy handling, availability of starting materials, use of non-toxic solvents, and high recyclability of nano-catalyst could be countered as most important advantages of this methodology.

Synthesis and identification of meta-(4-bromobenzyloxy) benzaldehyde thiosemicarbazone (MBBOTSC) as novel ligand for cadmium extraction by ultrasound assisted-dispersive-ionic liquid-liquid micro extraction method

“…Synthesis of TSC is performed in different ways: a) it is a two-step pathway in which hydrazine reacts with isothiocyanate and the product with aldehyde or ketone, which leads to TSCs [9], b) it is the opposite of pathway a, ie hydrazine first reacts with aldehydes or ketones and then the resulting compound reacts with isothiocyanate [10], c) it is a 4-step process, in which hydrazine first reacts with carbon disulfide and the resulting intermediate reacts with methyl iodide to form methylhydrazine thiocarbamate, eventually nucleophilic substitution with amines and a condensation reaction with an aldehyde or ketone produces TSC [11]. In continuation of our research on the synthesis of various compounds [12][13][14][15] and recent report introducing penicillamine as a metal chelator [16], herein, MBBOTSC as ligand containing sulfur and nitrogen has proposed as cadmium chelator.…”

“…The aim of the present study was to synthesize the meta-(4-bromobenzyloxy) benzaldehyde thiosemicarbazone derivative and to confirm its structure by spectroscopic methods such as FT-IR, 1 H-NMR, and 13 C-NMR and use it to separate and extract the cadmium ions from the water and wastewater samples before determined by AT-F-AAS. The meta-(4-bromo benzyloxy) benzaldehyde reacted with thiosemicarbazide under basic condition to form the target ligand.…”

“…Then the structure of the final ligand was identified by spectroscopic methods such as NNR and IR as well as TLC and melting point. In this study, the ligand structure was identified by spectroscopic methods such as 1 HNMR, 13 CNMR, and FTIR as well as melting point. Thin layer chromatography (TLC) was used to check the progress of the reaction (ethyl acetate and n-hexane were used as the mobile phase).…”

“…The structure, yield, melting point of synthesized compound is given in the Table 1. Also, the FT-IR, 1 H NMR and 13 C NMR spectra of the synthesized ligand are shown in Figures 3 to 5, respectively.…”

Literature Review: Synthesis Methods of NiFe2O4 Nanoparticles for Aqueous Battery Applications

“…The material characteristics change as the size approaches the nanoscale and as the percentage of atoms on the material's surface [1]. One type of nanoparticle is magnetic nanoparticles [2].…”