Nickel-doped cerium oxide nanoparticles: biosynthesis, cytotoxicity and UV protection studies

Miri, Abdolhossein; Sarani, Mina; Khatami, Mehrdad

doi:10.1039/c9ra09076b

Cited by 49 publications

(25 citation statements)

References 54 publications

(64 reference statements)

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“…D = kλ / β cosθ Eq. 2 Where, D is particle size on nanometer, k is a xed factor that is usually k=1, λ is wavelength of X-ray (3.54 Å), θ is radiation angle of X-ray (in degrees), and β is peak width in half height of the peak that be expressed in units of length [23]. nm, respectively (Fig.…”

Section: Pxrd Analysismentioning

confidence: 99%

Study of Photodegradation Performance and Ability of Lead Removal of Synthesized Maghemite Nanoparticles Using Ziziphus Jujuba Extract

Miri

Sedighi

Najafidoust

et al. 2021

Preprint

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Today, Water pollutants such as heavy metals and dyes are very important dangers to the nature. Metals such as lead, chromium, mercury and arsenic are examples of heavy metals which are toxic to living things, even sometime at the lowest concentrations. For resolve this challenge, Magnetic nanoparticles are attractive compound because of their advantages such as high efficiency, fast recovery capability, high surface area, easy transportation and inexpensive. We presented an easy and eco-friendly route for the synthesis of iron oxide nanoparticles using Ziziphus jujuba extract. In order to determine the physical, chemical and optical properties of the synthesized samples, Fourier-transform infrared (FT-IR), powder X-ray diffraction (PXRD), vibrating sample magnetometer (VSM), field emission scanning electron microscope (FESEM), energy dispersive X-ray (EDX), transmission electron microscopy (TEM), and Raman analyses were deployed. PXRD results showed that the synthesized nanoparticles have maghemite form of (γ-Fe2O3). FESEM and TEM results demonstrated that the size of these nanoparticles was in range of 20-50 nm, and had spherical shapes. Raman spectrum confirmed the cubic structure of γ-Fe2O3 NPs. Survey of magnetic properties showed that the synthesized maghemite nanoparticles (γ-Fe2O3 NPs) were superparamagnetic. The ability to remove lead from aqueous solution was investigated using these nanoparticles. The results showed that the synthesized nanoparticles were capable of removing 96% of lead at pH = 7 and 1 mg/L loading of nanoparticles. The photocatalytic activity of γ-Fe2O3 NPs was studied on methylene blue (MB) dye; as a result, MB at pH =7 and 1 gr dosage of γ-Fe2O3 had the highest removal percentage (92.8%) during 160 minute using γ-Fe2O3 which calcined at 400 ˚C. The reusability results showed that after four cycles of using the γ-Fe2O3-400, the obtained degradation of methylene blue was about 87.1%. Thus, synthesized γ-Fe2O3 NPs can be a good alternative for removing heavy metals and industrial dyes from contaminated waters.

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Section: Pxrd Analysismentioning

confidence: 99%

Study of Photodegradation Performance and Ability of Lead Removal of Synthesized Maghemite Nanoparticles Using Ziziphus Jujuba Extract

Miri

Sedighi

Najafidoust

et al. 2021

Preprint

Self Cite

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“…Adhering to the green chemistry principles [16] has provided safer routes for the production of CeO 2 NPs, which can be useful for drug applications; indeed, these methods offer cheaper and simpler options than the traditional chemical synthetic methods [17][18][19][20][21]. Another important factor for effective and important nanoparticles properties is the doping process as attested by several studies wherein the properties of doped nanoparticles with various metals have dramatic alterations compared to un-doped nanoparticles; synthetic methods for doped nanoparticles being similar [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Cytotoxic Performance of Pure and Co-Doped CeO2 Nanoparticles on Breast Cancer Cell, Colon Cancer Cell, and Mouse Embryo Fibroblast Cell Lines

Miri¹,

Sarani²,

Barani³

et al. 2022

Preprint

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Today, according to the progression and prevalence of cancer, efforts to discover new compounds to suppress the tumor and associated with less toxicity. Metal oxide nanoparticles have wide applications in biology and biomedicine due to their unique physical and chemical properties. They have great potential in the treatment of cancer, tumor targeting in tissues, targeted drug delivery, bioimaging, gene therapy and other diagnostic and therapeutic areas. So, in this study, a simple, inexpensive, and environmentally friendly method is described for the pure and 1, 4, and 8% cobalt doped cerium oxide nanoparticles (Co-doped CeO2 NPs) using aqueous extract of Biebersteinia multifidi roots, as a recommended compound for the treatment of cancer. The morphology and size of synthesized nanoparticles were determined using PXRD, UV-Vis, FESEM, EDX, and Raman methods wherein cobalt doped cerium oxide were identified as spherical in shape with an average size of 5-10 nm. The toxicity effect of synthesized pure and Co-doped CeO2 NPs on breast cancer cell (MCF7), colon cancer cell (CaCo2), and mouse embryo fibroblast cell (NIH-3T3) lines was examined using MTT assay; cerium oxide nanoparticles were non-toxic against cancer and normal cell lines while Co-doped CeO2 NPs displayed cytotoxic effects on MCF7 and CaCo2 cell lines, except for NIH-3T3 cell line compared to doxorubicin as control. Thus, synthesized Co-doped CeO2 NPs have shown an acceptable inhibitory effect on breast and colon cancer cell lines.

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“…Nanotechnology has brought a revolution in the pharmaceutical and biomedical sciences. The nanoalloy systems have a high surface-to-volume ratio that can significantly affect the therapeutic or diagnostic functioning [5][6][7][8][9][10][11]. Currently, transition bimetallic alloys are gaining popularity due to their enhanced functionalities [12,13].…”

Section: Introductionmentioning

confidence: 99%

CoNi alloy nanoparticles for cancer theranostics: synthesis, physical characterization, in vitro and in vivo studies

et al. 2021

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Nanomaterials are attracting increasing interest in many biomedical fields, including the fight against cancer. In this context, we successfully synthesized CoNi alloy nanoparticles (NPs) by a simple polyol process. The magnetic characteristics of the products were measured by vibration sample magnometry, which revealed that the samples have soft ferromagnetic behavior. The microstructure and morphology were inspected by X-ray diffraction and scanning electron microscopy, respectively. Human cancer cells derived from the breast (MCF7) and oral cavity (C152) and normal cells derived from human umbilical vein endothelial cells (HUVECs) were treated with increasing concentrations of CoNi NPs, and their cytotoxic effect was measured via MTT and lactate dehydrogenase (LDH) leakage assays. We found that treatments by using 12.5 to 400 µg/mL of Co0.5Ni0.5, Co0.6Ni0.4, and Co0.4Ni0.6 NPs were associated with significant concentration-dependent toxicity toward such cell lines and profoundly enhanced LDH leakage following 48 h of exposure (P < 0.05 compared with untreated cells). Besides, a NP dose of 6.25 µg/mL did not affect the survival of HUVECs while leading to marked cell death in MCF7 and C152 cells. In vivo experiments in rats were done to investigate the biochemical and histopathological changes over three weeks, following intraperitoneal administration of Co0.5Ni0.5, Co0.6Ni0.4, and Co0.4Ni0.6 NPs (100 mg/kg). As compared with the controls, the exposure to NPs caused significant elevations in aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, serum creatinine, serum catalase activity, serum superoxide dismutase, and liver malondialdehyde levels. Also, rats treated with Co0.6Ni0.4 NPs showed more severe histopathological changes of the liver and kidney. Our findings represent an essential step toward developing theranostic nanoplatforms for selective cancer treatment.

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Nickel-doped cerium oxide nanoparticles: biosynthesis, cytotoxicity and UV protection studies

Abstract: This study was conducted to obtain NixCe1−xO2 (where x = 0, 1, 3 and 5% w/w) nanoparticles using Salvadora persica extracts through an easy, inexpensive and non-toxic method.

Cited by 49 publications

References 54 publications

Study of Photodegradation Performance and Ability of Lead Removal of Synthesized Maghemite Nanoparticles Using Ziziphus Jujuba Extract

Study of Photodegradation Performance and Ability of Lead Removal of Synthesized Maghemite Nanoparticles Using Ziziphus Jujuba Extract

In Vitro Cytotoxic Performance of Pure and Co-Doped CeO2 Nanoparticles on Breast Cancer Cell, Colon Cancer Cell, and Mouse Embryo Fibroblast Cell Lines

CoNi alloy nanoparticles for cancer theranostics: synthesis, physical characterization, in vitro and in vivo studies

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