Nickel, cobalt and chromate sensitization and occupation<sup>*</sup>

Rui, Francesca; Bovenzi, Massimo; Prodi, Andrea; Fortina, Anna Belloni; Romano, Ilaria; Peserico, Andrea; Corradin, Maria Teresa; E, Carrabba; Filon, Francesca Larese

doi:10.1111/j.1600-0536.2009.01650.x

Cited by 61 publications

(71 citation statements)

References 38 publications

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“…Also, cobalt reactivity was very common when published studies on shoe dermatitis were pooled, as cobalt sensitization affected 13%, whereas nickel sensitization only affected 8% (17). Moreover, cobalt sensitization was significantly associated with textile and leather work [odds ratio (OR) 1.52; 95% confidence interval (CI) 1.09-2.12] in an Italian study on occupational contact dermatitis (18). In a later study by the same group, this finding was confirmed, as cobalt monosensitization (OR 1.85; 95% CI 1.10-3.09) and concomitant cobalt, nickel and chromium sensitization (OR 2.19; 95% CI 1.10-4.33) were significantly associated with textile and leather work (19).…”

Section: Discussionmentioning

confidence: 95%

Consumer leather exposure: an unrecognized cause of cobalt sensitization

et al. 2013

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Section: Discussionmentioning

confidence: 95%

Consumer leather exposure: an unrecognized cause of cobalt sensitization

et al. 2013

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“…20 Rui et al detected positivity in the ratios of 24,6% for nickel sulfate, 10,2% for cobalt chloride and 8,7% for potassium dicromat. 21 In other studies, the sensitivity ratio against nickel is reported to be 10-28,3% and it is emphasized to be higher in young ages and females. The other most frequently encountered allergens are reported to be cobalt chlorine, potassium dichromate, fragrance mix and Peru balsam.…”

Section: Discussionmentioning

confidence: 99%

•Evaluation of patch test results in patients with contact dermatitis

Yeşilova¹

2011

Dicle Med J

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ÖZETAmaç: Yama testi, allerjik kontakt dermatit tanısını doğ-rulayan ve kontakt allerjinin sebebini bulmamızı sağlayan en önemli tanısal yöntemdir Retrospektif olarak yapılan çalışmamızda, bölgemizde kontakt dermatitli hastaların yama testi sonuçlarının değerlendirilmesi amaçlanmıştır. Gereç ve yöntem:Kontakt dermatit tanısı alan hastaların 84'ü (%56) kadın, 66'sı (%44) erkek, toplam 150 hastaya Avrupa standart test serisi ile yama testi yapıldı. Test, Uluslararası Kontakt Dermatitis Araştırma Grubu tarafın-dan standardize edilmiştir. Bulgular:Lezyonların en sık ellerde (%36) yerleştiği gö-rüldü. 31''i kadın (%58,4), 21'i erkek (%41,6) olmak üzere toplam 72 hastada (%48) bir veya birden fazla maddeye karşı pozitif allerjik reaksiyon elde edildi. En sık reaksiyon saptanan allerjenler ise nikel sülfat (%13,3), potasyum dikromat (%11,3) ve kobalt klorid (%8,6) idi.Sonuç: Kontak dermatite nikel hassasiyetinin daha fazla olduğu bulundu. Sağlıklı kontrollerle karşılaştırıldığında kontakt dermatiti hastalarda deri yama testini daha sık görülmüştür. Anahtar kelimeler: Kontakt dermatit, yama testi, nikel sülfat ABSTRACTObjectives: Patch test is the most reliable method to diagnose allergic contact dermatitis and to find out the responsible contact allergen. The aim of this retrospective study was to evaluate the patch test results of patients with contact dermatitis in our region. Materials and methods:One Hundred fifty patients (84 female and 66 male) with contact dermatitis were patch tested with European standard test series. The testing has been standardized by the international Contact Dermatitis Research Group (ICDRG).Results: A majority of the lesions (36%) were localized on the hands. In 31 female (58,4%) and 21 male (4,6%) patients (a total of 72 patients) there were positive allergic reactions to at least one chemical. Nickel sulphate (13,3%), potassium dichromate (11,3%) and cobalt chloride (8,6%) were the most often allergens reacted. Conclusion:Nickel sensitivity is more common. Comparing with healthy controls contact sensitization may be more prevalent in patients with contact dermatitis.

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“…In addition to nickel (Ni), cobalt (Co), and palladium (Pd), which often induce metal allergy, chromium (Cr) has also been reported as a causal metal of allergic contact dermatitis. Cr hypersensitivity is one of the major occupational metal skin diseases especially in cement workers [2], [3]. Cr hypersensitivity is common in the general population with a prevalence of approximately 0.5% [4], [5], whereas the prevalence in cement workers is approximately 4.5% [4], [6].…”

Section: Introductionmentioning

confidence: 99%

Accumulation of Metal-Specific T Cells in Inflamed Skin in a Novel Murine Model of Chromium-Induced Allergic Contact Dermatitis

et al. 2014

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Chromium (Cr) causes delayed-type hypersensitivity reactions possibly mediated by accumulating T cells into allergic inflamed skin, which are called irritants or allergic contact dermatitis. However, accumulating T cells during development of metal allergy are poorly characterized because a suitable animal model is not available. This study aimed to elucidate the skewing of T-cell receptor (TCR) repertoire and cytokine profiles in accumulated T cells in inflamed skin during elucidation of Cr allergy. A novel model of Cr allergy was induced by two sensitizations of Cr plus lipopolysaccharide solution into mouse groin followed by single Cr challenge into the footpad. TCR repertoires and nucleotide sequences of complementary determining region 3 were assessed in accumulated T cells from inflamed skin. Cytokine expression profiles and T-cell phenotypes were determined by qPCR. CD3+CD4+ T cells accumulated in allergic footpads and produced increased T helper 1 (Th1) type cytokines, Fas, and Fas ligand in the footpads after challenge, suggesting CD4+ Th1 cells locally expanded in response to Cr. Accumulated T cells included natural killer (NK) T cells and Cr-specific T cells with VA11-1/VB14-1 usage, suggesting metal-specific T cells driven by invariant NKT cells might contribute to the pathogenesis of Cr allergy.

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Nickel, cobalt and chromate sensitization and occupation^*

Abstract: Our study showed interesting associations between some occupations and nickel, chromate and cobalt allergy.

Cited by 61 publications

References 38 publications

Consumer leather exposure: an unrecognized cause of cobalt sensitization

Consumer leather exposure: an unrecognized cause of cobalt sensitization

•Evaluation of patch test results in patients with contact dermatitis

Accumulation of Metal-Specific T Cells in Inflamed Skin in a Novel Murine Model of Chromium-Induced Allergic Contact Dermatitis

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Nickel, cobalt and chromate sensitization and occupation*

Abstract: Our study showed interesting associations between some occupations and nickel, chromate and cobalt allergy.

Cited by 61 publications

References 38 publications

Consumer leather exposure: an unrecognized cause of cobalt sensitization

Consumer leather exposure: an unrecognized cause of cobalt sensitization

•Evaluation of patch test results in patients with contact dermatitis

Accumulation of Metal-Specific T Cells in Inflamed Skin in a Novel Murine Model of Chromium-Induced Allergic Contact Dermatitis

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Product

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Nickel, cobalt and chromate sensitization and occupation^*