Abstract:The nickel and palladium catalyzed Kumada-Tamao-Corriu cross-coupling reaction is a powerful method for the formation of carbon-carbon bonds, employed in many large-scale applications in the pharmaceutical and electronic material industries. Kumada cross-coupling is the reaction of an organohalide substrate with a Grignard reagent to produce the corresponding coupled product using a palladium or nickel catalyst. This review covers key developments in Kumada cross-coupling reactions over the past ten years.
“…[1][2][3][4][5] Palladium and nickel-catalyzed cross-coupling reactions still play a prominent role in synthetic chemistry. [6][7][8][9][10][11][12][13][14][15][16][17] However, alternative cross-coupling protocols must be taken into consideration owing to the high cost of these transition metals, and their limited supply. [18][19][20][21][22][23][24] In addition to this, the development of broadly applicable, more environmental friendly and economical catalysts is a worthy target in catalytic crosscoupling reactions.…”
The cobalt, copper and chromium catalyzed cross-coupling reaction of various Grignard reagents with electrophilic substrates is a powerful technique for the construction of carbon-carbon bonds, enabling the preparation of a wide variety of organic compounds that are employed in the pharmaceutical industry, as agricultural compounds, and for forming organic electronic materials. This review highlights major developments in carbon-carbon cross-coupling reactions catalyzed by cobalt, copper and chromium complexes over the past decade.
“…[1][2][3][4][5] Palladium and nickel-catalyzed cross-coupling reactions still play a prominent role in synthetic chemistry. [6][7][8][9][10][11][12][13][14][15][16][17] However, alternative cross-coupling protocols must be taken into consideration owing to the high cost of these transition metals, and their limited supply. [18][19][20][21][22][23][24] In addition to this, the development of broadly applicable, more environmental friendly and economical catalysts is a worthy target in catalytic crosscoupling reactions.…”
The cobalt, copper and chromium catalyzed cross-coupling reaction of various Grignard reagents with electrophilic substrates is a powerful technique for the construction of carbon-carbon bonds, enabling the preparation of a wide variety of organic compounds that are employed in the pharmaceutical industry, as agricultural compounds, and for forming organic electronic materials. This review highlights major developments in carbon-carbon cross-coupling reactions catalyzed by cobalt, copper and chromium complexes over the past decade.
Novel nickel(ii) complexes [Ni(P,P)X2] = [Ni{tBuN(PPh2)2-κ2P}X2], X = Cl, Br, I, are prepared, characterized by IR and NMR spectroscopy, mass spectrometry and X-ray crystallography, and tested as catalysts in the Kumada cross-coupling reaction.
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