Nickel and palladium catalyzed Kumada-Tamao-Corriu cross-coupling reactions: scope and recent advances

Abstract

The nickel and palladium catalyzed Kumada-Tamao-Corriu cross-coupling reaction is a powerful method for the formation of carbon-carbon bonds, employed in many large-scale applications in the pharmaceutical and electronic material industries. Kumada cross-coupling is the reaction of an organohalide substrate with a Grignard reagent to produce the corresponding coupled product using a palladium or nickel catalyst. This review covers key developments in Kumada cross-coupling reactions over the past ten years.

Cobalt, copper, and chromium-catalyzed carbon-carbon coupling reactions using a broad spectrum of Grignard reagents as reaction partners

“…[1][2][3][4][5] Palladium and nickel-catalyzed cross-coupling reactions still play a prominent role in synthetic chemistry. [6][7][8][9][10][11][12][13][14][15][16][17] However, alternative cross-coupling protocols must be taken into consideration owing to the high cost of these transition metals, and their limited supply. [18][19][20][21][22][23][24] In addition to this, the development of broadly applicable, more environmental friendly and economical catalysts is a worthy target in catalytic crosscoupling reactions.…”