Nickel

Mastromatteo, Ernest

doi:10.1202/0002-8894(1986)047<0589:n>2.3.co;2

Cited by 6 publications

(10 citation statements)

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“…Ciccarelli et al (65) observed increased DNA strandbreaks and crosslinks in kidney nuclei from nickel carbonate-treated rats at doses of 15 or 20 mg/kg (ip), but no significant DNA damage was found in rats receiving 10-mg/kg nickel carbonate injection. Robison et al (67) confirmed the results in cultured CHO cells exposed to nickel chloride (1 p-l01Lg/mL) and crystalline nickel sulfide (1,5,20 14g/mL).…”

Section: Dna Strand Breaks and Crosslinksmentioning

confidence: 76%

“…Several hazardous factors in the nickel-producing occupational environments may play a role in nickel-induced high lung cancer risk (1,7,11). Among them, cigarette smoking, a well-known lung carcinogen, attracted much interest.…”

Section: Epidemiological Investigationsmentioning

confidence: 99%

“…Nickel, a metal used widely in modern industry, has been shown to exert many adverse effects on the human body (1,2). Among them, the carcinogenic effect and the correlation between nickel exposure and occupational lung cancer have attracted particular interest.…”

Section: Introductionmentioning

confidence: 99%

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Risk assessment of nickel carcinogenicity and occupational lung cancer.

Shen

Zhang

1994

Environ Health Perspect

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Recent progress in risk assessment of nickel carcinogenicity and its correlation with occupational lung cancer in nickelexposed workers is reviewed. Epidemiological investigations provide reliable data indicating the close relation between nickel exposure and high lung cancer risk, especially in nickel refieries. The nickel species-specific effects and the doseresponse relationship between nickel exposure and lung cancer are among the main questions that are explored extensively. It is also suggested that some confounding factors such as cigarette smoking cannot be neglected. The determination of nickel concentration in lung tissue may be conducive to estimating the nickel exposure level, but it is uncertain whether the high nickel content in lung tissue indicates high lung cancer risk in nickel-exposed workers. Immunologic studies suggest that the suppressive effect ofnickel on NK cell activity and interferon production may also be involved in the mechanisms of nickel carcinogenesis. As a potential mutagen, nickel can cause chromosome damage both in vitro and in vivo; and on a molecular basis, nickel is found to induce DNA damage (DNA strandbreaks and crosslinks, infidelity of DNA replication, inhibition ofDNA repair, and the helical transition ofB-DNA toZ-DNA) by binding ofnickel ions to DNA and nuclear proteins. The discovery of oncogene promises both a challenge and an opportunity for nickel carcinogenesis research. It can be predicted that, with the rapid development ofmolecular biology and oncology, new approaches will be established for both understanding and controlling nickel-induced occupational lung cancer.

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Section: Dna Strand Breaks and Crosslinksmentioning

confidence: 76%

Section: Epidemiological Investigationsmentioning

confidence: 99%

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Risk assessment of nickel carcinogenicity and occupational lung cancer.

Shen

Zhang

1994

Environ Health Perspect

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“…There is some evidence that nickel may be an essential trace element for mammals. Nickel occurs in nature in the nonionic and divalent states; other valence states occur very infrequently (Mastromatteo, 1986).…”

Section: Nickelmentioning

confidence: 99%

“…Inorganic nickel compounds are well-tolerated when taken orally by rodents in doses up to 500 m a g (Mastromatteo, 1986). Rats continually fed a 250 ppm nickel diet for 16 months suffered no deleterious effects and were considered in excellent condition (Phatak and Patwardhan, 1952).…”

Section: Toxicity In Soil Tomentioning

confidence: 99%