Niacin metabolism and indoleamine 2,3-dioxygenase activation in malnourished patients with flaky paint dermatosis

Maltos, André Luiz; Portari, Guilherme Vannucchi; Moraes, Giselle Vanessa; Monteiro, Marina Casteli Rodrigues; Vannucchi, Hélio; Cunha, Daniel Ferreira da

doi:10.1016/j.nut.2014.12.023

Cited by 18 publications

(15 citation statements)

References 11 publications

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“…Excess amino acid leucine inhibits QPRT, which prevents the formation of niacin or NA to nicotinic acid mononucleotide (NAMN) (189). Reduced tryptophan availability, particularly after chronic immune activation or in the absence of a tryptophan-rich diet (i.e., soy, meat, fish, eggs, and peanuts), may also be associated with the development of pellagra (217). Essential differences, however, may be observed between ADC and pellagra, as the latter develops as a result of a global bodily deficiency of tryptophan and niacin, while ADC develops as a result of increased tryptophan and NAD + catabolism at specific, although possibly numerous, sites (Fig.…”

mentioning

confidence: 99%

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Braidy

Berg

Clement

et al. 2019

Antioxidants & Redox Signaling

174

169

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mentioning

confidence: 99%

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Braidy

Berg

Clement

et al. 2019

Antioxidants & Redox Signaling

174

169

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“…The therapeutic effect of applying zinc ointment has shown promising results . Treatment with niacin supplements has given inconclusive results in a clinical trial, and the role of niacin is currently under investigation …”

Section: Discussionmentioning

confidence: 99%

“…25 Treatment with niacin supplements has given inconclusive results in a clinical trial, 17,20 and the role of niacin is currently under investigation. 26 Before we are able to use our score for skin evaluation in clinical studies, a test on the inter-and intra-observer variability must be made. After this, the generalizability of our results must be validated on an external cohort.…”

Section: Lichenoid Skin Changesmentioning

confidence: 99%

Characterization and scoring of skin changes in severe acute malnutrition in children between 6 months and 5 years of age

Heilskov

Vestergaard

Babirekere

et al. 2015

Acad Dermatol Venereol

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“…In the acute phase response to inflammation, certain cells, such as macrophages, are capable of producing interleukins that stimulate the action of these enzymes. Inflammation status itself can also increase nutrient consumption and trigger biochemical manifestations of deficiency [6].…”

Section: Introductionmentioning

confidence: 99%

Correlation Between First Morning Single Void and 24-Hour Urines: The Reliability to Quantify Niacin Status

Soldi

Maltos

Cunha

et al. 2018

Med Sci Monit Basic Res

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BackgroundThe current common practice when using urine as a biomarker for vitamin excretion is to use a 24-hour sample for analysis. Due to the difficulty involved in this process, we attempted to find an alternative solution through the use of a single first morning void. The aim of our study was to investigate if there is a correlation between the first morning single void and the 24-hour collections of urines for the urine metabolite of niacin, N-1-methylnicotinamide (N1MN), and to test the reliability of utilizing a method using first morning single void collections corrected with the concentration of urine creatinine.Material/MethodsAll urine samples were collected from 30 healthy adult volunteers over the age of 18 years: 20 females and 10 males. Samples were collected after discarding the first morning urine and collecting every other urine voided during the next 24 hours including the first morning urine of the day after in 2 separate vessels. We analyzed the concentration of N1MN by high performance liquid chromatography and the concentration of creatinine by a commercial kit by spectrophotometry. The B3 excretion was expressed as the ratio of N1MN to creatinine.ResultsWe found a significant correlation between the ratios of first morning single void and 24-hour urines. When comparing males and females, the ratio demonstrated a significant correlation as well.ConclusionsOur results demonstrated that it is possible to substitute a 24-hour collection with a first morning single void urine for the estimation of N1MN excretion.

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Niacin metabolism and indoleamine 2,3-dioxygenase activation in malnourished patients with flaky paint dermatosis

Cited by 18 publications

References 11 publications

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Characterization and scoring of skin changes in severe acute malnutrition in children between 6 months and 5 years of age

Correlation Between First Morning Single Void and 24-Hour Urines: The Reliability to Quantify Niacin Status

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