NHBA isolated from Gastrodia elata exerts sedative and hypnotic effects in sodium pentobarbital-treated mice

Adeninealkylresorcinol, the first alkylresorcinol tethered with nucleobase from Lasiodiplodia sp.

“…Nucleobase analogues are the most widely distributed nitrogenous heterocycles in nature, which exist in various forms including N-methylated [21][22], N-higher-alkylated [23][24], and N-glycosylated [25][26]. Furthermore, nucleobase analogues also combined with other types of natural compounds to form hybrid structures, such as acremolin [23], agelasine E [24], asmarine I [27], aplidiopsamine A [28], alachalasin A [29], aphrocallistin [30].…”

Interspecies Variation of In Vitro Stability and Metabolic Diversity of YZG-331, a Promising Sedative-Hypnotic Compound

“…Gastrodia elata , a popular Chinese herbal medicine, has been taken for the therapy of headache, insomnia, dizziness, and so on. N6-(4-hydroxybenzyl)-adenine riboside, an adenosine analog extracted from Gastrodia elata , was found to possess potent sedative and hypnotic activity ( Huang et al, 2007 ; Zhang et al, 2012 ). Subsequently, a detailed structure-effects relationship research of more than 150 derivatives for sedative and hypnotic activity was conducted.…”

Gastrolatathioneine, an unusual ergothioneine derivative from an aqueous extract of “tian ma”: A natural product co-produced by plant and symbiotic fungus

“…Therefore, as part of a program to systematically study the chemical diversity of traditional Chinese medicines and their biological effects [8−24], an aqueous decoction of the G. elata rhizomes was investigated. We previously reported isolation and structure characterization of 49 compounds, including 14 new 4-hydroxybenzyl-substituted amino acids and glutathione derivatives, from the aqueous extract, as well as preliminary bioassays of those isolates [25−27] and pharmacological functions of a minor component N 6 -(4-hydroxybenzyl)adenosine (NHBA) [28,29]. Herein, we report the isolation and structure elucidation of an unusual natural product derived from ergothioneine, named gastrolatathioneine (1) (Fig.…”