Adeninealkylresorcinol, the first alkylresorcinol tethered with nucleobase from Lasiodiplodia sp.

Gao, Yumeng; Sun, Tianyu; Ma, Min; Chen, Guo-Dong; Zhou, Zheng-Qun; Wang, Chuanxi; Hu, Dan; Chen, Liguo; Yao, Xin‐Sheng; Gao, Hao

doi:10.1016/j.fitote.2016.06.011

Cited by 9 publications

(2 citation statements)

References 26 publications

(31 reference statements)

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“…Structural variations in plant MARs are usually related to the alkyl substituent; for example, DNA-polymerase inhibiting bis-5-alkylresorcinols isolated from the angiosperm Panopsis rubescens 9 bear two terminal resorcinol rings on each side of the alkyl chain. Some additional structural features are noteworthy in non-plant MARs: for example, monochasiols isolated from the slime mold Dictyostelium monochasioides contain a chlorinated phenolic ring, while adeninealkylresorcinol, isolated from the fungus Lasiodiplodia sp.,10 features a nucleobase moiety. O -Methylation is also common in MARs 1…”

Section: Structural Variety and Biological Activity Of Alkylresorcinomentioning

confidence: 99%

Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols

et al. 2019

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Section: Structural Variety and Biological Activity Of Alkylresorcinomentioning

confidence: 99%

Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols

et al. 2019

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“…Among our recent discoveries [11,12,13,14,15,16,17,18,19,20,21], we recently reported that a strain of Streptomyces sp. HK-2006-1 produced both aldgamycins and chalcomycins, which are 16-membered macrolides [11,21].…”

Section: Introductionmentioning

confidence: 99%

Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities

et al. 2017

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Dihydrochalcomycin (1) and chalcomycin (2), two known chalcomycins, and chalcomycin E (3), a new compound, were isolated from marine-derived Streptomyces sp. HK-2006-1. Their structures were elucidated by detailed spectroscopic and X-ray crystallographic analysis. The antimicrobial activities against Staphylococcus aureus, Escherichia coli, Candida albicans, and Aspergillus niger of 1-3 were evaluated. Compounds 1-2 exhibited activities against S. aureus with minimal inhibitory concentrations (MICs) of 32 µg/mL and 4 µg/mL, respectively. The fact that 1-2 showed stronger activity against S. aureus 209P than 3 indicated that the epoxy unit was important for antimicrobial activity. This structure-activity tendency of chalcomycins against S. aureus is different from that of aldgamycins reported in our previous research, which provide a valuable example for the phenomenon that 16-membered macrolides with different sugars do not have parallel structure-activity relationships.

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Exploring the antioxidant potential of endophytic fungi: a review on methods for extraction and quantification of total antioxidant capacity (TAC)

Asomadu,

Ezeorba,

Ezike

et al. 2024

3 Biotech

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Endophytic fungi have emerged as a significant source of natural products with remarkable bioactivities. Recent research has identified numerous antioxidant molecules among the secondary metabolites of endophytic fungi. These organisms, whether unicellular or micro-multicellular, offer the potential for genetic manipulation to enhance the production of these valuable antioxidant compounds, which hold promise for promoting health, vitality, and various biotechnological applications. In this study, we provide a critical review of methods for extracting, purifying, characterizing, and estimating the total antioxidant capacity (TAC) of endophytic fungi metabolites. While many endophytes produce metabolites similar to those found in plants with established symbiotic associations, we also highlight the existence of novel metabolites with potential scientific interest. Additionally, we discuss how advancements in nanotechnology have opened new avenues for exploring nanoformulations of endophytic metabolites in future studies, offering opportunities for diverse biological and industrial applications.

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Adeninealkylresorcinol, the first alkylresorcinol tethered with nucleobase from Lasiodiplodia sp.

Cited by 9 publications

References 26 publications

Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols

Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols

Chalcomycins from Marine-Derived Streptomyces sp. and Their Antimicrobial Activities

Exploring the antioxidant potential of endophytic fungi: a review on methods for extraction and quantification of total antioxidant capacity (TAC)

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