In this work, we describe the synthesis of new 4‐organyl‐5‐(organylselanyl)thiazol‐2‐amine hybrids through a one‐pot two‐step protocol. The transition metal‐free method involves the use of ultrasound as an alternative energy source and Oxone® as oxidant. To obtain the products, a telescoping approach was used, in which 4‐organylthiazol‐2‐amines were firstly prepared under ultrasonic irradiation, followed by the addition of diorganyl diselenides and Oxone®. Thus, 16 compounds were prepared, with yields ranging from 61 % to 98 %, using 2‐bromoacetophenone derivatives and diorganyl diselenides as easily available starting materials.