NG-24 Neutron Generator for Nuclear Medicine and Thermonuclear Research

Syromukov, S. V.; Stepnov, V. V.; Dobrov, R. V.; Sysoev, V. I.; Mel’nik, Alina; Bogatikov, K. V.; Старостин, А. Н.; Letichevskii, R. D.

doi:10.1007/s10512-015-0031-5

Cited by 16 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the dimensions of ITER machine with major radius exceeding 6 m and minor -exceeding 2 m [17], we provision the use of NG-24 neutron generator manufactured by FSUE VNIIA [18], the main technical specifications of this model are listed in Table I. The sketch of the NG irradiation unit is illustrated in Several details that constitute the know-how of the manufacturer were omitted.…”

Section: A Neutron Generatormentioning

confidence: 99%

Characterization of the Fast Neutron Generators for Calibration of Fusion Neutron Diagnostics

Kormilitsyn,

Pankratenko,

Kashchuk

et al. 2023

EPJ Web Conf.

View full text Add to dashboard Cite

Modern magnetic confinement fusion devices increasingly rely on extensive neutron diagnostic configurations to measure a plethora of key plasma parameters. Measurement accuracy for these diagnostics depends heavily on in situ calibration. In order to enable said calibration, we set out to propose a reliable and powerful fast neutron source, to define a characterization plan for this source in terms of yield, flux and energy distributions, propose an optimized set of tools suitable for online monitoring of neutron source performance and its metrological characteristics. In the framework of this research activity with the ultimate aim of ITER tokamak neutron diagnostics calibration we rely on industrial-grade fast neutron generator NG-24 (D-D neutron yield ~109 n/s, D-T neutron yield ~1011 n/s) with sealed tube and stuffed, titanium target developed by FSUE VNIIA. The well-known analytical expressions for thick target NGs and our measurements using neutron spectrometers utilizing threshold reactions – diamond detector and LaCl3 scintillator for D-T and D-D neutron generators respectively – were found to be significantly coherent. These data are supported through our multi-step forward modelling including ion stopping in target, fusion reaction kinematics modelling and calculating detector response based on modelled neutron spectra. We discuss methods of uncertainty mitigation of neutron spectrometer measurements. Application of both neutron activation analysis and gas-filled neutron flux monitors during source characterization and operation allows for lowing statistical uncertainty of neutron flux measurements to 1% level over 1 minute of time resolution. Over the course of several measurement campaigns the optimal set of measurement tools have been determined including detector dimensions, required acquisition time, calibration methods.

show abstract

Section: A Neutron Generatormentioning

confidence: 99%

Characterization of the Fast Neutron Generators for Calibration of Fusion Neutron Diagnostics

Kormilitsyn,

Pankratenko,

Kashchuk

et al. 2023

EPJ Web Conf.

View full text Add to dashboard Cite

show abstract

“…The nuclear reaction 3H(d,n) generates 14–15 MeV neutrons. Due to a big reaction cross section (5 barn at 107 keV), one can obtain a flux of >1011 neutrons/s [4, 5]. Theoretical calculations and experiments showed that the neutron energy (14.71–14.87 MeV) was practically linearly dependent on the accelerating voltage [6, 7].…”

Section: Introductionmentioning

confidence: 99%

A Unique Prototypic Device for Radiation Therapy: The p53-Independent Antiproliferative Effect of Neutron Radiation

Yurkov

Syromukov

Tatarskiy³

et al. 2019

Acta Naturae

Self Cite

View full text Add to dashboard Cite

Radiation therapy with heavy particles including neutrons, an otherwise therapeutically perspective because of its high tissue penetration and efficient tumor damage, is currently limited by the lack of adequate equipment. An NG-24 generator (140 kg, 42 110 cm, ~1011 particles/s, 14 MeV) has been designed and engineered to replace the huge and environmentally harmful neutron reactors, cyclotrons, and accelerators with a compact, portable, safe, and potent source of high-energy neutrons. We demonstrate that the neutron beam produced by NG-24 causes a significant antiproliferative effect on human tumor cell lines regardless of the status of the anti-apoptotic p53 protein. Phosphorylation of histone 2A and increased amounts of p21, cyclin D, and phospho-p53 were detectable in HCT116 colon carcinoma cells (wild-type p53) irradiated with 4 Gy several days post-treatment, accompanied by G2/M phase arrest. These treatments dramatically reduced the ability of single cells to form colonies. In the HCT116p53KO subline (p53 -/-), the G2/M arrest was independent of the aforementioned mechanisms. Hence, the NG-24 generator is a source of a powerful, therapeutically relevant neutron flux that triggers a p53-independent antiproliferative response in tumor cells.

show abstract

Comparison of D–D and D–T Tubes for Neutron Generators with Sorbed and Stuffed Targets

Syromukov

2020

At Energy

View full text Add to dashboard Cite

NG-24 Neutron Generator for Nuclear Medicine and Thermonuclear Research

Cited by 16 publications

References 1 publication

Characterization of the Fast Neutron Generators for Calibration of Fusion Neutron Diagnostics

Characterization of the Fast Neutron Generators for Calibration of Fusion Neutron Diagnostics

A Unique Prototypic Device for Radiation Therapy: The p53-Independent Antiproliferative Effect of Neutron Radiation

Comparison of D–D and D–T Tubes for Neutron Generators with Sorbed and Stuffed Targets

Contact Info

Product

Resources

About