NF-κB does not influence the induction of apoptosis by Ukrain

Mendoza, Julia; Zamora, Rubén; Gallardo, J.; Ceballos, Gisela; Aldana, Aida; Espinosa, Magali; Maldonado, Vilma; Meléndez-Zajgla, Jorge

doi:10.4161/cbt.5.7.2752

Cited by 5 publications

(3 citation statements)

References 33 publications

(31 reference statements)

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“…In our present study, sanguinarine reduced the expression of the NF-κB protein. This inhibitory effect may be specific to sanguinarine and may not be observed in other structural analogues of sanguinarine (21,37). Our results are also supported by other studies where the decrease of NF-κB expression in K562 erythroleukemia cells was observed following treatment with 4.5 µmol/l of sanguinarine (5).…”

supporting

confidence: 91%

Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis

Meng

Chong

et al. 2012

Oncology Reports

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Sanguinarine, a natural benzophenanthridine alkaloid, has been shown to possess anticancer activity in vitro and in vivo. In the present study, we demonstrated that sanguinarine caused a dose-dependent inhibition of growth in HeLa and SiHa human cervical cancer cells, i.e., 2.43 µmol/l (IC50) in HeLa cells and 3.07 µmol/l in SiHa cells. Cell cycle analysis revealed that sanguinarine significantly increased the sub-G1 population, from 1.7 to 59.7% in HeLa cells and from 1.7 to 41.7% in SiHa cells. Sanguinarine caused a dose-dependent decrease in Bcl-2 and NF-κB protein expression and a significant increase in Bax protein expression. Our findings indicate that sanguinarine as an effective anticancer drug candidate inhibits the growth of cervical cancer cells through the induction of apoptosis.

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supporting

confidence: 91%

Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis

Meng

Chong

et al. 2012

Oncology Reports

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“…Plumbagin mediated activation of caspase 3 and caspase 9 has been shown earlier in ME180 cervical cancer cells [11]. Recent studies using Shikonin and Ukrain have shown that HeLa cell apoptosis is induced through the activation of caspases [17, 18]. K562 cells treated with radiation and herbimycin A had an accelerated cell death and induced a p53 independent apoptosis.…”

Section: Discussionmentioning

confidence: 86%

Radiosensitizing effects of plumbagin in cervical cancer cells is through modulation of apoptotic pathway

Nair

Srinivas

et al. 2007

Molecular Carcinogenesis

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Radiotherapy is the primary line of cancer treatment for cervical cancer and is known to induce cell death in tumors. Radiotherapy is however limited by the total dose that can be given without damaging normal tissue. Plumbagin, a naturally occurring naphthaquinone, has been reported to have free radical producing properties. Hence we hypothesized that plumbagin could also have properties that could modify effects of radiation on cervical cancer cells. Radiation in combination with plumbagin may thus have treatment augmenting effects. Results from our studies have shown that a lower dose of radiation in combination with plumbagin could induce apoptosis more effectively compared to a higher dose of radiation alone. Plumbagin in combination with 2 Gy of radiation was very effective in inducing apoptosis, when compared to a higher radiation dose of 10 Gy alone. This combination also showed a fivefold increase in the activation of caspase 3 in C33A cells. Activation of effector caspases confirms that the induction of apoptosis by irradiation and plumbagin involves caspase‐dependent pathways. Expression of apoptotic regulatory molecules Bcl‐2, Bax and Survivin was also modulated by plumbagin in combination with radiation. In summary, this study shows that a combination of plumbagin and radiation augmented cell growth inhibition compared to higher radiation dose alone, thus indicating that plumbagin may be a potential radiosensitizer acting through the induction of apoptosis. © 2007 Wiley‐Liss, Inc.

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“…However, Huang et al (2000) showed that the NF-κB/IκB signaling pathway was involved in Paclitaxel-induced apoptosis of breast and ovarian cancers. Moreover, Mendoza et al's data indicated that NF-κB activation was not involved in the Ukrain-induced apoptosis (Mendoza et al 2006). To sum up, the role of NF-κB in cancer therapy may be a double-edged sword-it can possess both anti-and pro-apoptotic effects (Olivier et al 2006;Pikarsky and BenNeriah 2006).…”

Section: Introductionmentioning

confidence: 96%

Dexamethasone enhances trichosanthin-induced apoptosis in the HepG2 hepatoma cell line

Chen

Liu

et al. 2010

Life Sciences

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NF-κB does not influence the induction of apoptosis by Ukrain

Cited by 5 publications

References 33 publications

Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis

Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis

Radiosensitizing effects of plumbagin in cervical cancer cells is through modulation of apoptotic pathway

Dexamethasone enhances trichosanthin-induced apoptosis in the HepG2 hepatoma cell line

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